Topics with new or revised events include Disease (Defects in biotin metabolism, Defects in cobalamin (B12) metabolism and TGF-beta receptor complex signaling in cancer), Signal transduction (Signaling by Leptin), Extracellular matrix organization (Degradation of the extracellular matrix, Laminin interactions, and Integrin cell surface interactions), Transmembrane transport of small molecules (TRP channels), Cell cycle (Regulation of PLK1 activity at G2/M transition), and Cellular response to stress (Cellular senescence). Rosemary J Akhurst, Wytse Bruinsma, Lei He, Dominique Meyer, Steven W Polyak, Sylvie Ricard-Blum, Shamith Samarajiwa, Thomas Scherer, and David Watkins are our external reviewers. Plant Reactome has released a new batch of rice pathways associated with cofactor biosynthesis, hormone biosnythesis, and fatty acids & lipids biosynthesis. Examples include: pyridoxamine anabolism, ABA biosynthesis and mediated signaling and glycolipid desaturation. The Reactome FI plugin, which was designed to find network patterns related to cancer and other types of diseases within a gene list, has been upgraded to support Cytoscape v3, and is now available at the Cytoscape app store.