Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
[April 15, 2024] In the December issue of Toxicology and Applied Pharmacology, Zhang et al. (2023) used the R package, ReactomePA (Yu and He, 2016) to identify enriched pathways responding to nickel-induced transcriptional memory changes in response to a second respiratory toxicant, nicotine. Nicotine exposure upregulated a specific subset of genes in the cells previously exposed to nickel, identifying a robust activation of interferon (IFN) signaling, a driver of inflammation associated with many chronic lung diseases.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 88 released on March 27th, 2024
2,698
Human Pathways
15,212
Reactions
11,442
Proteins
2,128
Small Molecules
1,047
Drugs
38,549
Literature References
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