BioPAX pathway converted from "CDK1 phosphorylates MAPK6" in the Reactome database.

2.7.11.22

CDK1 phosphorylates MAPK6

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 29358

nucleoplasmGO0005654

ATP(4-) [ChEBI:30616]

ATP(4-)

Adenosine 5'-triphosphateatpATP

Reactomehttp://www.reactome.orgChEBI30616

Reactome DB_ID: 10003353

UniProt:E2QVF3MAPK6

Canis familiaris

NCBI Taxonomy9615UniProtE2QVF3

Chain Coordinates

EQUAL

721

EQUAL

Reactome DB_ID: 10004993

O-phospho-L-serine at 684 (in Homo sapiens)

684

EQUAL

O-phospho-L-serine [MOD:00046]

O-phospho-L-serine at 688 (in Homo sapiens)

688

EQUAL

O-phospho-L-threonine at 698 (in Homo sapiens)

698

EQUAL

O-phospho-L-threonine [MOD:00047]

O-phospho-L-serine at 705 (in Homo sapiens)

705

EQUAL

721

EQUAL

Reactome DB_ID: 113582

ADP(3-) [ChEBI:456216]

ADP(3-)

ADP trianion5'-O-[(phosphonatooxy)phosphinato]adenosineADP

ChEBI456216PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 9945743

UniProt:E2RGJ9CDK1

UniProtE2RGJ9

O-phospho-L-threonine at 161 (in Homo sapiens)

161

EQUAL

297

EQUAL

GO0004693

GO molecular function

Reactome Database ID Release 7510005011Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005011Reactome Database ID Release 7510005013Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10005013ReactomeR-CFA-5692755

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5692755.1MAPK6 is hyperphosphorylated by CDK1 at multiple sites in the C-terminal extension, and this phosphorylation is associated with the stabilization of MAPK6 protein in mitosis. Residues S684, S688, T698 and S705 have been identified as in vitro targets of CDK1, and phosphorylation of T698 has also been demonstrated in vivo (Tanguay et al, 2010). The role of hyperphosphorylated MAPK6 during mitosis has not been established, and although the CDK1-dependent phosphorylation of MAPK6 is depicted as occuring in the nucleus, the site of action has also not been determined. CDK1-dependent hyperphosphorylation of the C-terminal tail is reversed by the phosphatases CDC14A and B (Tanguay et al, 2010; Hansen et al, 2008).

20236090Pubmed2010C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosisTanguay, Pierre-LucRodier, GenevièveMeloche, SylvainBiochem. J. 428:103-1118235225Pubmed2008A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3Hansen, Christina AaenBartek, JiriJensen, SanneCell Cycle 7:325-34inferred by electronic annotationIEAGOIEA