BioPAX pathway converted from "ANKLE2 is deacetylated by SIRT2" in the Reactome database.ANKLE2 is deacetylated by SIRT2ANKLE2 is deacetylated by SIRT2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100261991endoplasmic reticulum membraneGO0005789UniProt:E2R7S4ANKLE2Reactomehttp://www.reactome.orgCanis familiarisNCBI Taxonomy9615UniProtE2R7S4N6-acetyl-L-lysine at 302 (in Homo sapiens)302EQUALN6-acetyl-L-lysine [MOD:00064]Chain Coordinates1EQUAL938EQUALReactome DB_ID: 293601cytosolGO0005829NAD(1-) [ChEBI:57540]NAD(1-)NAD(+)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD anionChEBI57540Reactome DB_ID: 293561water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 998876611EQUAL938EQUALReactome DB_ID: 1972771nicotinamide [ChEBI:17154]nicotinamideChEBI17154Reactome DB_ID: 966795612''-O-acetyl-ADP-D-ribose [ChEBI:76279]2''-O-acetyl-ADP-D-riboseChEBI76279PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10026203UniProt:F1PTX2SIRT2UniProtF1PTX22EQUAL389EQUALGO0034979GO molecular functionReactome Database ID Release 7510026204Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026204Reactome Database ID Release 7510026206Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026206ReactomeR-CFA-96679521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-9667952.1ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).22770216Pubmed2012Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosisAsencio, ClaudioDavidson, Iain FSantarella-Mellwig, RachelLy-Hartig, Thi Bach NgaMall, MoritzWallenfang, Matthew RMattaj, Iain WGorjánácz, MátyásCell 150:122-3527875273Pubmed2016SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylationKaufmann, TanjaKukolj, EvaBrachner, AndreasBeltzung, EtienneBruno, MelaniaKostrhon, SebastianOpravil, SusanneHudecz, OttoMechtler, KarlWarren, GrahamSlade, DeaJ. Cell. Sci. 129:4607-4621inferred by electronic annotationIEAGOIEA