BioPAX pathway converted from "UCH proteinases" in the Reactome database.UCH proteinasesUCH proteinasesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ADRM1 binds 26S proteasomeADRM1 binds 26S proteasomeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100008601cytosolGO0005829UniProt:E2RDP4ADRM1Reactomehttp://www.reactome.orgCanis familiarisNCBI Taxonomy9615UniProtE2RDP4Chain Coordinates2EQUAL407EQUALReactome DB_ID: 9933926126S proteasome [cytosol]26S proteasomeReactome DB_ID: 99338201UniProt:F1PPH7PSMC2UniProtF1PPH72EQUAL433EQUALReactome DB_ID: 99338321UniProt:E2RM61PSMC5UniProtE2RM612EQUAL406EQUALReactome DB_ID: 99338521UniProt:J9JHD9PSMD12UniProtJ9JHD92EQUAL456EQUALReactome DB_ID: 99337721UniProt:F1PUB5PSMA7UniProtF1PUB51EQUAL248EQUALReactome DB_ID: 99338641UniProt:E2QUY7PSMD3UniProtE2QUY71EQUAL534EQUALReactome DB_ID: 99337641UniProt:E2R4H4PSMA5UniProtE2R4H41EQUAL241EQUALReactome DB_ID: 99338481UniProt:E2RJ26PSMD11UniProtE2RJ262EQUAL422EQUALReactome DB_ID: 99338361UniProt:J9P1N0LOC100687259UniProtJ9P1N01EQUAL389EQUALReactome DB_ID: 99338561UniProt:E2R5N5PSMD13UniProtE2R5N51EQUAL376EQUALReactome DB_ID: 99338161UniProt:F1PQ40PSMC1UniProtF1PQ402EQUAL440EQUALReactome DB_ID: 99337461UniProt:F1PGY4PSMD14UniProtF1PGY41EQUAL310EQUALReactome DB_ID: 99337841UniProt:E2QW34PSMB2UniProtE2QW341EQUAL201EQUALReactome DB_ID: 99337921UniProt:E2RBR6PSMB4UniProtE2RBR646EQUAL264EQUALReactome DB_ID: 99338981UniProt:F6UY11PSME1UniProtF6UY111EQUAL249EQUALReactome DB_ID: 99338081UniProt:Q5W416PSMB8UniProtQ5W41673EQUAL276EQUALReactome DB_ID: 99337961UniProt:E2R3R2PSMB5UniProtE2R3R260EQUAL263EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99338781Homologues of PSMD5 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPSMD5 [cytosol]PSMD5 [cytosol]UniProtJ9P2T7UniProtF1P7L2Reactome DB_ID: 99338121UniProt:Q5W412PSMB9UniProtQ5W41221EQUAL219EQUALReactome DB_ID: 99338601UniProt:E2RCP9PSMD2UniProtE2RCP91EQUAL908EQUALReactome DB_ID: 99339021UniProt:F1PD77PSME2UniProtF1PD772EQUAL239EQUALReactome DB_ID: 99339141UniProt:F1PXW1PSME4UniProtF1PXW11EQUAL1843EQUALReactome DB_ID: 99338821UniProt:E2RN00PRICKLE2UniProtE2RN001EQUAL389EQUALReactome DB_ID: 99339181UniProt:E2RF52PSMA8UniProtE2RF521EQUAL256EQUALReactome DB_ID: 99339241Ghost homologue of SHFM1 [cytosol]Ghost homologue of SHFM1Reactome DB_ID: 99338241UniProt:F1PBK7PSMC3UniProtF1PBK71EQUAL439EQUALReactome DB_ID: 99339061UniProt:E2RPY9PSME3UniProtE2RPY92EQUAL254EQUALReactome DB_ID: 99338901UniProt:E2QY43PSMD8UniProtE2QY431EQUAL350EQUALReactome DB_ID: 99338941UniProt:E2R0R1PSMD9UniProtE2R0R11EQUAL223EQUALReactome DB_ID: 99337881UniProt:E2QX17PSMB3UniProtE2QX172EQUAL205EQUALReactome DB_ID: 99338441UniProt:E2RA22PSMD10UniProtE2RA221EQUAL226EQUALReactome DB_ID: 99337501UniProt:J9P9G4UniProtJ9P9G41EQUAL263EQUALReactome DB_ID: 99338041UniProt:E2RPC6PSMB7UniProtE2RPC644EQUAL277EQUALReactome DB_ID: 99338401UniProt:F1PX57PSMD1UniProtF1PX571EQUAL953EQUALReactome DB_ID: 99338681UniProt:F1PRW0PSMD4UniProtF1PRW01EQUAL377EQUALReactome DB_ID: 99337761UniProt:F1PF02PSMB1UniProtF1PF0229EQUAL241EQUALReactome DB_ID: 99337541UniProt:E2R1C3UniProtE2R1C32EQUAL234EQUALReactome DB_ID: 99339101UniProt:E2QT82PSMF1UniProtE2QT821EQUAL271EQUALReactome DB_ID: 99338281UniProt:E2RH48PSMC4UniProtE2RH481EQUAL418EQUALReactome DB_ID: 99337601Ghost homologue of PSMA4 [cytosol]Ghost homologue of PSMA4Reactome DB_ID: 99337801UniProt:E2RKR9PSMB10UniProtE2RKR940EQUAL273EQUALReactome DB_ID: 99338861UniProt:J9P6R1PSMD7UniProtJ9P6R11EQUAL324EQUALReactome DB_ID: 99339221UniProt:F1Q1R2UniProtF1Q1R250EQUAL300EQUALReactome DB_ID: 99337681UniProt:E2RMN2PSMA6UniProtE2RMN21EQUAL246EQUALReactome DB_ID: 99337581UniProt:E2RKR4PSMA3UniProtE2RKR42EQUAL255EQUALReactome DB_ID: 99338001UniProt:E2R0B6PSMB6UniProtE2R0B635EQUAL239EQUALReactome Database ID Release 759933926Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9933926ReactomeR-CFA-688191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-68819.1Reactome DB_ID: 100008621ADRM1:26S proteasome [cytosol]ADRM1:26S proteasomeReactome DB_ID: 1000086012EQUAL407EQUALReactome DB_ID: 99339261Reactome Database ID Release 7510000862Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10000862ReactomeR-CFA-56658581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665858.1Reactome Database ID Release 7510000889Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10000889ReactomeR-CFA-56658711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665871.1ADRM1 (also called Rpn13) interacts with the 26S proteasome base unit PRDM1 (Rpn2) via its amino-terminus and is found in the majority of 26S proteasomes. It is a receptor for Ubiquitin (Ub) that can bind K48-linked di-Ub (Schreiner et al. 2008, Husnjak et al. 2008) and de-ubiquitinating enzymes (DUBs) such as PSMD14 (Rpn11, POH1), USP14, and UCHL5 (UCH37) (Reyes-Turcu et al., 2009). Together, these DUBs disassemble poly-Ub chains and recycle ubiquitin during proteasomal degradation.18497817Pubmed2008Proteasome subunit Rpn13 is a novel ubiquitin receptorHusnjak, KoraljkaElsasser, SuzanneZhang, NaixiaChen, XiangRandles, LeahShi, YuanHofmann, KayWalters, Kylie JFinley, DanielDikic, IvanNature 453:481-818497827Pubmed2008Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionSchreiner, PatrickChen, XiangHusnjak, KoraljkaRandles, LeahZhang, NaixiaElsasser, SuzanneFinley, DanielDikic, IvanWalters, Kylie JGroll, MichaelNature 453:548-5219489724Pubmed2009Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesReyes-Turcu, Francisca EVentii, Karen HWilkinson, Keith DAnnu. Rev. Biochem. 78:363-97inferred by electronic annotationIEAGOIEAADRM1:26S proteaseome binds UCHL5ADRM1:26S proteaseome binds UCHL5This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100008561UniProt:E2QWM9UCHL5UniProtE2QWM91EQUAL329EQUALReactome DB_ID: 100008621Reactome DB_ID: 100008641ADRM1:26S proteasome:UCHL5 [cytosol]ADRM1:26S proteasome:UCHL5Reactome DB_ID: 1000085611EQUAL329EQUALReactome DB_ID: 100008621Reactome Database ID Release 7510000864Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10000864ReactomeR-CFA-56658451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665845.1Reactome Database ID Release 7510000866Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10000866ReactomeR-CFA-56658541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665854.1The C-terminal extension of UCHL5 (UCH37) binds to ADRM1, part of the proteasomal 19S regulatory subunit which is itself a subunit of the 26S proteasome. Binding of UCHL5 enhances its DUB activity (Qiu et al. 2006). UCHL5 forms oligomers in solution that have very low DUB activity. Binding with ADRM1 is 1:1, preventing oligomerization of UCHL5 while making the active site of UCHL5 accessible to Ubiquitin (Jiao et al. 2014). When associated with the proteasome, UCHL5 disassembles poly-Ub chains by hydrolyzing the distal ubiquitin from a chain. This dissassembly of the degradation signal from only the distal end of polyubiquitin chains may selectively rescue poorly ubiquitinated or slowly degraded Ub-protein conjugates from proteolysis (Lam et al. 1997). 17139257Pubmed2006hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Qiu, XBOuyang, Song-YingLi, Chao-JunMiao, ShiyingWang, LinfangGoldberg, Alfred LEMBO J. 25:5742-5316990800Pubmed2006A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesHamazaki, JunIemura, SNatsume, TYashiroda, HidekiTanaka, KeijiMurata, ShigeoEMBO J. 25:4524-3624752541Pubmed2014Mechanism of the Rpn13-induced activation of Uch37Jiao, LianyingOuyang, SongyingShaw, NeilSong, GaojieFeng, YingangNiu, FengfengQiu, WeichengZhu, HongtaoHung, Li-WeiZuo, XiaobingEleonora Shtykova, VZhu, PingDong, Yu-HuiXu, RuxiangLiu, Zhi-JieProtein Cell 5:616-309034192Pubmed1997Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeLam, Y AXu, WDeMartino, G NCohen, R ENature 385:737-40inferred by electronic annotationIEAGOIEAUCHL5 binds INO80 complexUCHL5 binds INO80 complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100036571nucleoplasmGO00056541EQUAL329EQUALReactome DB_ID: 100036551INO80 complex [nucleoplasm]INO80 complexReactome DB_ID: 100036171UniProt:E2RIW3NFRKBUniProtE2RIW31EQUAL1299EQUALReactome DB_ID: 100036331UniProt:J9PBC6UniProtJ9PBC61EQUAL356EQUALReactome DB_ID: 99676361UniProt:E2RQC9RUVBL1UniProtE2RQC91EQUAL456EQUALReactome DB_ID: 100036291UniProt:F1PVB9ACTR8UniProtF1PVB91EQUAL624EQUALReactome DB_ID: 100036491UniProt:E2RE54INO80DUniProtE2RE541EQUAL878EQUALReactome DB_ID: 99894481UniProt:F1Q0F8ACTL6AUniProtF1Q0F82EQUAL429EQUALReactome DB_ID: 100036411UniProt:E2RHE9YY1UniProtE2RHE91EQUAL414EQUALReactome DB_ID: 100036451UniProt:F6XXC7TFPTUniProtF6XXC71EQUAL253EQUALReactome DB_ID: 100036251UniProt:F1PSS0ACTR5UniProtF1PSS01EQUAL607EQUALReactome DB_ID: 100036531UniProt:E2QRR3INO80EUniProtE2QRR31EQUAL244EQUALReactome DB_ID: 99903861UniProt:F6XE95MCRS1UniProtF6XE951EQUAL462EQUALReactome DB_ID: 99957981UniProt:O18840ACTBUniProtO188401EQUAL375EQUALReactome DB_ID: 100036371UniProt:E2RM51INO80CUniProtE2RM511EQUAL192EQUALReactome DB_ID: 100036211UniProt:F1PKX5INO80UniProtF1PKX51EQUAL1556EQUALReactome Database ID Release 7510003655Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003655ReactomeR-CFA-56895681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689568.1Reactome DB_ID: 100036591UCHL5:INO80 complex [nucleoplasm]UCHL5:INO80 complexReactome DB_ID: 1000365711EQUAL329EQUALReactome DB_ID: 100036551Reactome Database ID Release 7510003659Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003659ReactomeR-CFA-56896021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689602.1Reactome Database ID Release 7510003661Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003661ReactomeR-CFA-56895441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689544.1The C-terminal extension of UCHL5 (UCH37) binds NFRKB within the INO80 chromatin remodeling complex (Yao et al. 2006, 2008, Conoway & Conoway 2009).19062292Pubmed2009The INO80 chromatin remodeling complex in transcription, replication and repairConaway, Ronald CConaway, Joan WelikyTrends Biochem. Sci. 34:71-718922472Pubmed2008Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complexYao, TingtingSong, LJin, JingjiCai, YongTakahashi, HidehisaSwanson, Selene KWashburn, Michael PFlorens, Laurence AConaway, Ronald CCohen, Robert EConaway, Joan WMol. Cell 31:909-1716906146Pubmed2006Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1Yao, TingtingSong, LXu, WeiDeMartino, George NFlorens, Laurence ASwanson, Selene KWashburn, Michael PConaway, Ronald CConaway, Joan WelikyCohen, Robert ENat. Cell Biol. 8:994-1002inferred by electronic annotationIEAGOIEABAP1 binds BAP1-interacting complexBAP1 binds BAP1-interacting complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100036651UniProt:E2R3W8BAP1UniProtE2R3W81EQUAL729EQUALReactome DB_ID: 100036891BAP1-interacting complex [nucleoplasm]BAP1-interacting complexReactome DB_ID: 100036871BAP1-interacting core complex [nucleoplasm]BAP1-interacting core complexConverted from EntitySet in ReactomeReactome DB_ID: 100036751ASXL1,ASXL2 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityASXL2 [nucleoplasm]ASXL1 [nucleoplasm]UniProtE2RR41UniProtF1PTX5Reactome DB_ID: 99903981UniProt:E2QSQ5OGTUniProtE2QSQ52EQUAL1046EQUALConverted from EntitySet in ReactomeReactome DB_ID: 100036851FOXK1,FOXK2 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityFOXK2 [nucleoplasm]FOXK1 [nucleoplasm]UniProtH9GWC4UniProtF1Q2J8Reactome DB_ID: 99774671UniProt:E2QXV1HCFC1UniProtE2QXV12EQUAL2035EQUALReactome Database ID Release 7510003687Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003687ReactomeR-CFA-56896781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689678.1Reactome DB_ID: 1000364111EQUAL414EQUALReactome Database ID Release 7510003689Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003689ReactomeR-CFA-56896531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689653.1Reactome DB_ID: 100036911BAP1:BAP1-interacting complex [nucleoplasm]BAP1:BAP1-interacting complexReactome DB_ID: 1000366511EQUAL729EQUALReactome DB_ID: 100036891Reactome Database ID Release 7510003691Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003691ReactomeR-CFA-56896821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689682.1Reactome Database ID Release 7510003693Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003693ReactomeR-CFA-56896301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689630.1BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that binds the RING finger domain of the breast and ovarian tumor suppressor BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013).<br><br>The C-terminal coiled coil motif of BAP1 directly interacts with the zinc fingers of the transcription factor Yin Yang 1 (YY1) (Yu et al. 2010), part of a multiprotein complex containing numerous transcription factors and cofactors including the transcriptional regulator Host cell factor 1 (HCFC1), which binds the N-terminal portion of BAP1 (Misaghi et al. 2009, Machida et al. 2009). HCFC1 is a chromatin-associated protein initially identified as part of a multiprotein complex comprising the viral coactivator VP16 and the POU domain transcription factor POU2F1. During herpes simplex virus infection, this complex is recruited to the enhancer/promoter of the immediate-early gene to activate viral gene expression (Kristie et al. 2010). <br><br>The C-terminal extension of UCHL5 mediates association with Adrm1/Rpn13 of the proteasomal 19S regulatory subunit and with NFRKB of the INO80 chromatin remodeling complex. The extreme C-terminal segment of BAP1 is 38% identical to the C-terminus of UCHL5 (UCH37) and is necessary for binding to YY1 (Yu et al. 2010).19188440Pubmed2009Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Misaghi, ShahramOttosen, SørenIzrael-Tomasevic, AnitaArnott, DavidLamkanfi, MohamedLee, JamesLiu, JinfengO'Rourke, KarenDixit, Vishva MWilson, Angus CMol. Cell. Biol. 29:2181-9219815555Pubmed2009The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1Machida, Yuichi JMachida, YukaVashisht, Ajay AWohlschlegel, James ADutta, AnindyaJ. Biol. Chem. 284:34179-8819117993Pubmed2009BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activityNishikawa, HiroyukiWu, WenwenKoike, AyakaKojima, RyokoGomi, HiromichiFukuda, MamoruOhta, TomohikoCancer Res. 69:111-920805357Pubmed2010The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expressionYu, HelenMashtalir, NazarDaou, SalimaHammond-Martel, IanRoss, JulieSui, GuangchaoHart, Gerald WRauscher, Frank JDrobetsky, ElliotMilot, EricShi, YangAffar, El BachirMol. Cell. Biol. 30:5071-8523277170Pubmed2013Tumours associated with BAP1 mutationsMurali, RajmohanWiesner, ThomasScolyer, Richard APathology 45:116-269528852Pubmed1998BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionJensen, D EProctor, MMarquis, S TGardner, H PHa, S IChodosh, L AIshov, A MTommerup, NVissing, HSekido, YMinna, JBorodovsky, ASchultz, D CWilkinson, K DMaul, G GBarlev, NBerger, S LPrendergast, G CRauscher, F JOncogene 16:1097-11219682612Pubmed2010Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activitiesKristie, Thomas MLiang, YVogel, Jodi LBiochim. Biophys. Acta 1799:257-65inferred by electronic annotationIEAGOIEABAP1 binds Ub-HCFC1BAP1 binds Ub-HCFC1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100046121ubiquitinylated lysine (K48-polyUb, K63-polyUb [nucleoplasm]) at 1807 (in Homo sapiens)1807EQUALubiquitinylated lysine [MOD:01148]2EQUAL2035EQUALReactome DB_ID: 1000366511EQUAL729EQUALReactome DB_ID: 100046141BAP1:K48polyUb,K63polyUb-HCFC1 [nucleoplasm]BAP1:K48polyUb,K63polyUb-HCFC1Reactome DB_ID: 100046121ubiquitinylated lysine (K48-polyUb, K63-polyUb [nucleoplasm]) at 1807 (in Homo sapiens)1807EQUAL2EQUAL2035EQUALReactome DB_ID: 1000366511EQUAL729EQUALReactome Database ID Release 7510004614Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004614ReactomeR-CFA-56907601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690760.1Reactome Database ID Release 7510004623Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004623ReactomeR-CFA-56907851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690785.1BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Eletr & Wilkinson 2011, Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth, though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated. The major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).21484256Pubmed2011An emerging model for BAP1's role in regulating cell cycle progressionEletr, Ziad MWilkinson, Keith DCell Biochem. Biophys. 60:3-11inferred by electronic annotationIEAGOIEABAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1135181water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 100046141Reactome DB_ID: 100046161BAP1:HCFC1 [nucleoplasm]BAP1:HCFC1Reactome DB_ID: 1000366511EQUAL729EQUALReactome DB_ID: 997746712EQUAL2035EQUALReactome Database ID Release 7510004616Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004616ReactomeR-CFA-56908171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690817.1Converted from EntitySet in ReactomeReactome DB_ID: 100046181K48-polyUb, K63-polyUb [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10004614GO0004843GO molecular functionReactome Database ID Release 7510004619Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004619Reactome Database ID Release 7510004621Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004621ReactomeR-CFA-56907591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690759.1BRCA1 associated protein 1 (BAP1) is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013). BAP1 mediates the deubiquitination of Host cell factor 1 (HCFC1) thereby regulating cell growth (Eletr & Wilinson 2011), though deubiquitination of HCFC1 does not lead to increased HCFC1 stability. HCFC1 is K48 and K63 ubiquitinated; the major site of linkage are lysines 1807 and 1808 (Machida et al. 2009).inferred by electronic annotationIEAGOIEAHistone H2A is dubiquitinated by the PR-DUB complexHistone H2A is dubiquitinated by the PR-DUB complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1135181Converted from EntitySet in ReactomeReactome DB_ID: 100041651Ub-histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityConverted from EntitySet in ReactomeReactome DB_ID: 99341311Ub [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityUBA52 [nucleoplasm]UBB(77-152) [nucleoplasm]UBB [nucleoplasm]UBB(1-76) [nucleoplasm]UBB(153-228) [nucleoplasm]RPS27A [nucleoplasm]UniProtP63050UniProtJ9NVT1UniProtF1PDG4UniProtF1PEZ4Converted from EntitySet in ReactomeReactome DB_ID: 99910711Histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10004637PR-DUB complex [nucleoplasm]PR-DUB complexConverted from EntitySet in ReactomeReactome DB_ID: 100046351MBD5,MBD6 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityMBD5 [nucleoplasm]MBD6 [nucleoplasm]UniProtF1PJZ2UniProtJ9P500Reactome DB_ID: 99893051UniProt:E2RKM1KDM1BUniProtE2RKM11EQUAL822EQUALConverted from EntitySet in ReactomeReactome DB_ID: 100036851Reactome DB_ID: 997746712EQUAL2035EQUALReactome DB_ID: 100046251PR-DUB core complex [nucleoplasm]PR-DUB core complexConverted from EntitySet in ReactomeReactome DB_ID: 100036751Reactome DB_ID: 1000366511EQUAL729EQUALReactome Database ID Release 7510004625Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004625ReactomeR-CFA-56907931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690793.1Reactome Database ID Release 7510004637Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004637ReactomeR-CFA-56908071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690807.1Reactome Database ID Release 7510004638Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004638Reactome Database ID Release 7510004640Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004640ReactomeR-CFA-56907901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690790.1BAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).20436459Pubmed2010Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBScheuermann, Johanna Cde Ayala Alonso, Andrés GaytánOktaba, KatarzynaLy-Hartig, NgaMcGinty, Robert KFraterman, SvenWilm, MatthiasMuir, Tom WMüller, JürgNature 465:243-722878500Pubmed2012Loss of the tumor suppressor BAP1 causes myeloid transformationDey, AnweshaSeshasayee, DhayaNoubade, RajkumarFrench, Dorothy MLiu, JinfengChaurushiya, Mira SKirkpatrick, Donald SPham, Victoria CLill, Jennie RBakalarski, Corey EWu, JianshengPhu, LilianKatavolos, PaulaLaFave, Lindsay MAbdel-Wahab, OmarModrusan, ZoraSeshagiri, SomasekarDong, KenLin, ZhonghuaBalazs, MercedeszSuriben, RowenaNewton, KimHymowitz, SarahGarcia-Manero, GuillermoMartin, FlaviusLevine, Ross LDixit, Vishva MScience 337:1541-624634419Pubmed2014MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domainBaymaz, H IremFournier, AlexandraLaget, SophieJi, ZonglingJansen, Pascal W T CSmits, Arne HFerry, LaureMensinga, AnneloesPoser, InaSharrocks, AndrewDefossez, Pierre-AntoineVermeulen, MichielProteomics 14:2179-89inferred by electronic annotationIEAGOIEAUCHL1, UCHL3 cleave ubiquitin adductsUCHL1, UCHL3 cleave ubiquitin adductsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100045681UCHL1,UCHL3:Ub-Lys [cytosol]UCHL1,UCHL3:Ub-LysConverted from EntitySet in ReactomeReactome DB_ID: 100045221UCHL1,UCHL3 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityUCHL1 [cytosol]UCHL3 [cytosol]UniProtF6XVD7UniProtF1PT17Converted from EntitySet in ReactomeReactome DB_ID: 100045661Ub-Lys [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityN6-glycyl-L-lysine-UBB(153-228) [cytosol]N6-glycyl-L-lysine-UBB(1-76) [cytosol]N6-glycyl-L-lysine-UBB(77-152) [cytosol]RPS27A [cytosol]UBA52 [cytosol]UBB [cytosol]Reactome Database ID Release 7510004568Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004568ReactomeR-CFA-67826331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6782633.1Reactome DB_ID: 293561Reactome DB_ID: 11318711cytoplasmGO0005737L-lysinium(1+) [ChEBI:32551]L-lysinium(1+)L-lysine monocationInChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1C6H15N2O2L-lysine[NH3+]CCCC[C@H]([NH3+])C([O-])=OL-lysiniumKDXKERNSBIXSRK-YFKPBYRVSA-O147.19558(2S)-2,6-diammoniohexanoateChEBI32551Reactome DB_ID: 100045701UCHL1,UCHL3:Ub [cytosol]UCHL1,UCHL3:UbConverted from EntitySet in ReactomeReactome DB_ID: 100045221Converted from EntitySet in ReactomeReactome DB_ID: 99337381Ub [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS27A [cytosol]UBB [cytosol]UBA52 [cytosol]UBB(1-76) [cytosol]UBB(77-152) [cytosol]UBB(153-228) [cytosol]Reactome Database ID Release 7510004570Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004570ReactomeR-CFA-67825921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6782592.1PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10004568Reactome Database ID Release 7510004571Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004571Reactome Database ID Release 7510004573Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004573ReactomeR-CFA-56903191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690319.1UCHL1 and UCHL3 can hydrolyze several short C-terminal ubiquitin adducts to generate ubiquitin monomers (Wilkinson et al. 1989, Wada et al. 1998, Larsen et al. 1998). This liberates small molecule nucleophiles that may have inadvertently reacted with Ub C-terminal thiolesters. Because these enzymes can cleave small peptides from the C-terminus of Ub, they could also function in recycling Ub from incomplete proteasomal or lysosomal protein degradation. UCHL3, but not UCHL1, is able to cleave the C-terminus of Neural precursor cell expressed developmentally downregulated protein 8 (NEDD8), a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases (Wada et al. 1998, Enchev et al. 2015). UCHL1 and 3 are specifically expressed in neurons, cells of the diffuse neuroendocrine system and their tumors. A polymorphism (S18Y) in UCHL1 is associated with a reduced risk for Parkinson's disease (Wang et al. 2002) and its overexpression is protective in models of Alzheimer's disease (Gong et al. 2006). UCHL1 has been shown to interact with alpha-synuclein, but as a ubiquitin ligase rather than as a ubiquitin hydrolase (Liu et al. 2002). It is K63-polyubiquitinated by Parkin in cooperation with the Ubc13/Uev1a E2 ubiquitin-conjugating enzyme complex, promoting UCH-L1 degradation by the autophagy-lysosome pathway (McKeon et al. 2015).9521656Pubmed1998Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolasesLarsen, C NKrantz, B AWilkinson, K DBiochemistry 37:3358-6812408865Pubmed2002The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityLiu, YichinFallon, LaraLashuel, Hilal ALiu, ZhihuaLansbury, Peter TCell 111:209-1825403879Pubmed2015Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome systemMcKeon, Jeanne ESha, DiLi, LianChin, Lih-ShenCell. Mol. Life Sci. 72:1811-2425531226Pubmed2015Protein neddylation: beyond cullin-RING ligasesEnchev, Radoslav ISchulman, Brenda APeter, MatthiasNat. Rev. Mol. Cell Biol. 16:30-449790970Pubmed1998Cleavage of the C-terminus of NEDD8 by UCH-L3Wada, HKito, KCaskey, L SYeh, E TKamitani, TBiochem. Biophys. Res. Commun. 251:688-922530630Pubmed1989The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolaseWilkinson, K DLee, K MDeshpande, SDuerksen-Hughes, PBoss, J MPohl, JScience 246:670-316923396Pubmed2006Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memoryGong, BingCao, ZixuanZheng, PingVitolo, Ottavio VLiu, ShuminStaniszewski, AgnieszkaMoolman, DonnaZhang, HongShelanski, MichaelArancio, OttavioCell 126:775-8812210873Pubmed2002ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onsetWang, JianZhao, Chun-YingSi, Yan-MeiLiu, Zhuo-LinChen, BiaoYu, LongMov. Disord. 17:767-71inferred by electronic annotationIEAGOIEAUCHL3, SENP8 cleave NEDD8UCHL3, SENP8 cleave NEDD8This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100046501UCHL3,SENP8:NEDD8(1-88) [cytosol]UCHL3,SENP8:NEDD8(1-88)Reactome DB_ID: 100046481UniProt:F1P890NEDD8UniProtF1P8901EQUAL88EQUALConverted from EntitySet in ReactomeReactome DB_ID: 100046461UCHL3,SENP8 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySENP8 [cytosol]UCHL3 [cytosol]UniProtE2RNH6Reactome Database ID Release 7510004650Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004650ReactomeR-CFA-67826351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6782635.1Reactome DB_ID: 293561Reactome DB_ID: 100046541UCHL3,SENP8:NEDD8 [cytosol]UCHL3,SENP8:NEDD8Reactome DB_ID: 1000465211EQUAL76EQUALConverted from EntitySet in ReactomeReactome DB_ID: 100046461Reactome Database ID Release 7510004654Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004654ReactomeR-CFA-67826431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6782643.1Reactome DB_ID: 10004656177EQUAL88EQUALPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10004650GO0019784GO molecular functionReactome Database ID Release 7510004657Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004657Reactome Database ID Release 7510004659Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10004659ReactomeR-CFA-56908081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5690808.1UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NEDD8 propeptides, exposing a C-terminal Gly residue. UCHL3 can also process ubiquitin (Wada et al. 1998). UCHL3 and SENP8 are probably functionally redundant in NEDD8 processing as deletion of either enzyme does not lead to neddylation defects (Chan et al. 2008, Kurihara et al. 2000).18782863Pubmed2008DEN1 deneddylates non-cullin proteins in vivoChan, YaruYoon, JeongsookWu, June-TaiKim, Hyung-JunPan, Kuan-TingYim, JeongbinChien, Cheng-TingJ. Cell. Sci. 121:3218-2310713173Pubmed2000Expression and functional analysis of Uch-L3 during mouse developmentKurihara, L JSemenova, ELevorse, J MTilghman, S MMol. Cell. Biol. 20:2498-504inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510029339Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10029339ReactomeR-CFA-56896031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5689603.1DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).19243136Pubmed2009Polyubiquitin binding and disassembly by deubiquitinating enzymesReyes-Turcu, Francisca EWilkinson, Keith DChem. Rev. 109:1495-50816325574Pubmed2005A genomic and functional inventory of deubiquitinating enzymesNijman, Sebastian M BLuna-Vargas, Mark P AVelds, ArnoBrummelkamp, Thijn RDirac, Annette M GSixma, Titia KBernards, RCell 123:773-86inferred by electronic annotationIEAGOIEA