BioPAX pathway converted from "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane" in the Reactome database.

3.1.3.64

PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 1806276

plasma membraneGO0005886

1-phosphatidyl-1D-myo-inositol 3-phosphate [ChEBI:17283]

1-phosphatidyl-1D-myo-inositol 3-phosphate

1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate)PtdIns3PPtdIns-3-PPhosphatidylinositol 3-phosphate

Reactomehttp://www.reactome.orgChEBI17283

Reactome DB_ID: 29356

cytosolGO0005829

water [ChEBI:15377]

water

ChEBI15377

Reactome DB_ID: 426658

1-phosphatidyl-1D-myo-inositol [ChEBI:16749]

1-phosphatidyl-1D-myo-inositol

ChEBI16749

Reactome DB_ID: 29372

hydrogenphosphate [ChEBI:43474]

hydrogenphosphate

[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUP

ChEBI43474PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Converted from EntitySet in Reactome

Reactome DB_ID: 10057708

MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityMTMR3 [cytosol]MTMR14 [cytosol]MTMR6 [cytosol]

Bos taurus

NCBI Taxonomy9913UniProtA0A3Q1LMW0UniProtA0A3Q1LZ59UniProtA0A3Q1LYK5GO0004438

GO molecular function

Reactome Database ID Release 7510057709Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057709Reactome Database ID Release 7510057711Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057711ReactomeR-BTA-1675994

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1675994.1At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002, Kim et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Kim et al. 2002, Tronchere et al. 2004), 3 (MTMR3) (Kim et al. 2002, Zhao et al. 2001, Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Kim et al. 2002, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).

10224048Pubmed1999SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatasesGuo, SStolz, LELemrow, SMYork, JDJ Biol Chem 274:12990-514660569Pubmed2004Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cellsTronchère, HLaporte, JPendaries, CChaussade, CLiaubet, LPirola, LMandel, JLPayrastre, BJ Biol Chem 279:7304-1211733541Pubmed2002Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth diseaseKim, SATaylor, GSTorgersen, KMDixon, JEJ Biol Chem 277:4526-3111676921Pubmed2001Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificityWalker, DMUrbé, SDove, SKTenza, DRaposo, GClague, MJCurr Biol 11:1600-517008356Pubmed2006A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathyTosch, VRohde, HMTronchère, HZanoteli, EMonroy, NKretz, CDondaine, NPayrastre, BMandel, JLLaporte, JHum Mol Genet 15:3098-10616914545Pubmed2006Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domainChoudhury, PSrivastava, SLi, ZKo, KAlbaqumi, MNarayan, KCoetzee, WALemmon, MASkolnik, EYJ Biol Chem 281:31762-917651088Pubmed2007Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomesCao, CLaporte, JBacker, JMWandinger-Ness, AStein, MPTraffic 8:1052-6712646134Pubmed2003Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatasesSchaletzky, JDove, SKShort, BLorenzo, OClague, MJBarr, Francis ACurr Biol 13:504-912118066Pubmed2002The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane rufflesLaporte, JBlondeau, FGansmuller, ALutz, YVonesch, JLMandel, JLJ Cell Sci 115:3105-1711302699Pubmed2001FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphateZhao, RQi, YChen, JZhao, ZJExp Cell Res 265:329-3815840652Pubmed2005Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3Lorenzo, OUrbé, SClague, MJJ Cell Sci 118:2005-12inferred by electronic annotationIEAGOIEA