BioPAX pathway converted from "RUNX3 regulates YAP1-mediated transcription" in the Reactome database.RUNX3 regulates YAP1-mediated transcriptionRUNX3 regulates YAP1-mediated transcriptionThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RUNX3 binds TEADs and YAP1RUNX3 binds TEADs and YAP1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 100690721nucleoplasmGO0005654YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)Reactome DB_ID: 100226021UniProt:F1MK73Reactomehttp://www.reactome.orgBos taurusNCBI Taxonomy9913UniProtF1MK73Chain Coordinates1EQUAL504EQUALConverted from EntitySet in ReactomeReactome DB_ID: 100690701TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityTEAD4 [nucleoplasm]TEAD1 [nucleoplasm]UniProtF1MED8UniProtE1BPE5Reactome Database ID Release 7010069072Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10069072ReactomeR-BTA-89516781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951678.1Reactome DB_ID: 100645791UniProt:E1B8P0UniProtE1B8P01EQUAL415EQUALReactome DB_ID: 100690741RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)Reactome DB_ID: 100690721Reactome DB_ID: 1006457911EQUAL415EQUALReactome Database ID Release 7010069074Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10069074ReactomeR-BTA-89516791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951679.1Reactome Database ID Release 7010069076Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10069076ReactomeR-BTA-89516761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951676.1RUNX3 interacts with both YAP1 and TEAD proteins. The interaction with YAP1 involves the PY motif of RUNX3 and the WW domain of YAP1. The interaction with TEADs involves the Runt domain of RUNX3 and the DNA recognition helix of TEADs. RUNX3 was shown to directly interact with TEAD1 and TEAD4. Based on sequence similarity, it is highly probable that RUNX3 also interacts with TEAD2 and TEAD3. The interaction of RUNX3 with YAP1 and/or TEADs does not prevent formation of the YAP1:TEADs complex (Yagi et al. 1999, Qiao et al. 2015).26364597Pubmed2016RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancerQiao, YLin, S JChen, YVoon, D C-CZhu, FChuang, L S HWang, TTan, PLee, S CYeoh, K GSudol, MIto, YOncogene 35:2664-7410228168Pubmed1999A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activatorYagi, RChen, L FShigesada, KMurakami, YIto, YEMBO J. 18:2551-62inferred by electronic annotationIEAGOIEAReactome Database ID Release 7010076833Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10076833ReactomeR-BTA-89516711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951671.1Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).18579750Pubmed2008TEAD mediates YAP-dependent gene induction and growth controlZhao, BYe, XinYu, JLi, LLi, WLi, SimingYu, JianjunLin, Jiandie DWang, Cun-YuChinnaiyan, Arul MLai, ZCGuan, KLGenes Dev. 22:1962-71inferred by electronic annotationIEAGOIEA