BioPAX pathway converted from "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)" in the Reactome database. 3.2.1.45 Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 1861764 1 cytosol GO 0005829 D-glucosyl-N-acylsphingosine [ChEBI:18368] D-glucosyl-N-acylsphingosine Glucocerebroside Glucosylceramide N-acyl-D-glucosylsphingosine Reactome http://www.reactome.org ChEBI 18368 Reactome DB_ID: 29356 1 water [ChEBI:15377] water ChEBI 15377 Reactome DB_ID: 70113 1 alpha-D-glucose [ChEBI:17925] alpha-D-glucose ChEBI 17925 Reactome DB_ID: 194377 1 N-acylsphingosine [ChEBI:52639] N-acylsphingosine ceramide ceramide d18:1(4c) N-acylsphingosines ChEBI 52639 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10090403 UniProt:F6XBY5 Canis familiaris NCBI Taxonomy 9615 UniProt F6XBY5 Chain Coordinates 1 EQUAL 469 EQUAL GO 0004348 GO molecular function Reactome Database ID Release 83 10090404 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090404 Reactome Database ID Release 83 10090406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090406 Reactome R-CFA-1861789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1861789.1 Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). 12594539 Pubmed 2003 Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Nemeth, K Plumb, GW Berrin, JG Juge, N Jacob, Ralf Naim, HY Williamson, G Swallow, DM Kroon, PA Eur J Nutr 42:29-42 11784319 Pubmed 2002 Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides Berrin, JG McLauchlan, WR Needs, P Williamson, G Puigserver, A Kroon, PA Juge, N Eur J Biochem 269:249-58 inferred by electronic annotation IEA GO IEA