BioPAX pathway converted from "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" in the Reactome database. 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29356 1 cytosol GO 0005829 water [ChEBI:15377] water Reactome http://www.reactome.org ChEBI 15377 Reactome DB_ID: 10106047 1 plasma membrane GO 0005886 SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin Reactome DB_ID: 10106045 1 UniProt:A0A5F4CQS8 Canis familiaris NCBI Taxonomy 9615 UniProt A0A5F4CQS8 Chain Coordinates 1 EQUAL 1071 EQUAL Reactome DB_ID: 10106041 1 RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] RAC1:GTP:FMNL1:Profilin:G-actin Reactome DB_ID: 10106039 1 RAC1:GTP:FMNL1 [plasma membrane] RAC1:GTP:FMNL1 Reactome DB_ID: 10106037 1 FMNL1 [cytosol] FMNL1 Reactome DB_ID: 10106035 2 UniProt:J9P103 UniProt J9P103 2 EQUAL 1100 EQUAL Reactome Database ID Release 82 10106037 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106037 Reactome R-CFA-5665949 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665949.1 Reactome DB_ID: 10046859 1 RAC1:GTP [plasma membrane] RAC1:GTP Reactome DB_ID: 29438 1 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI 37565 Reactome DB_ID: 10046857 1 UniProt:F1PYQ1 UniProt F1PYQ1 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10046859 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10046859 Reactome R-CFA-442641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-442641.1 Reactome Database ID Release 82 10106039 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106039 Reactome R-CFA-5663231 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5663231.1 Reactome DB_ID: 10057904 2 Profilin:G-actin [cytosol] Profilin:G-actin Converted from EntitySet in Reactome Reactome DB_ID: 10057902 1 PFN [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 10057890 1 G-actin [cytosol] G-actin Reactome DB_ID: 113592 1 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP ChEBI 30616 Converted from EntitySet in Reactome Reactome DB_ID: 10057888 1 actin [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity ACTB [cytosol] ACTG1 [cytosol] UniProt O18840 UniProt J9NXE2 Reactome Database ID Release 82 10057890 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057890 Reactome R-CFA-201857 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201857.1 Reactome Database ID Release 82 10057904 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10057904 Reactome R-CFA-203080 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-203080.1 Reactome Database ID Release 82 10106041 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106041 Reactome R-CFA-5665660 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665660.1 Reactome Database ID Release 82 10106047 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106047 Reactome R-CFA-5665803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665803.1 Reactome DB_ID: 10065012 1 RAC1:GDP [cytosol] RAC1:GDP Reactome DB_ID: 29420 1 GDP(3-) [ChEBI:58189] GDP(3-) guanosine 5'-diphosphate(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate trianion GDP GDP trianion guanosine 5'-diphosphate ChEBI 58189 Reactome DB_ID: 10065010 1 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10065012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10065012 Reactome R-CFA-445010 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-445010.1 Reactome DB_ID: 10106045 1 1 EQUAL 1071 EQUAL Reactome DB_ID: 10106037 1 Reactome DB_ID: 29372 1 hydrogenphosphate [ChEBI:43474] hydrogenphosphate [PO3(OH)](2-) HYDROGENPHOSPHATE ION hydrogen phosphate [P(OH)O3](2-) HPO4(2-) phosphate INORGANIC PHOSPHATE GROUP ChEBI 43474 Reactome DB_ID: 10057904 2 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10106047 GO 0003924 GO molecular function Reactome Database ID Release 82 10106050 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106050 Reactome Database ID Release 82 10106052 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10106052 Reactome R-CFA-5665809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5665809.1 SRGAP2 is a GTPase activating protein that stimulates the GTPase activity of RAC1 bound to FMNL1. GTP hydrolysis produces inactive GDP-bound RAC1 which is unable to bind and activate FMNL1. SRGAP2 thereby limits the duration of FMNL1-mediated elongation of actin filaments downstream of RAC1:GTP (Mason et al. 2011). 21148482 Pubmed 2011 Bi-modal regulation of a formin by srGAP2 Mason, Frank M Heimsath, Ernest G Higgs, Henry N Soderling, Scott H J. Biol. Chem. 286:6577-86 inferred by electronic annotation IEA GO IEA