BioPAX pathway converted from "ATM phosphorylates NBN" in the Reactome database. 2.7.11.1 ATM phosphorylates NBN ATM phosphorylates NBN This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29358 1 nucleoplasm GO 0005654 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 10110457 1 DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10039286 1 UniProt:J9JHR5 Canis familiaris NCBI Taxonomy 9615 UniProt J9JHR5 O-phospho-L-serine at 1981 (in Homo sapiens) 1981 EQUAL O-phospho-L-serine [MOD:00046] N6-acetyl-L-lysine at 3016 (in Homo sapiens) 3016 EQUAL N6-acetyl-L-lysine [MOD:00064] Chain Coordinates 1 EQUAL 3056 EQUAL Reactome DB_ID: 10039263 1 UniProt:A0A5F4DEP4 UniProt A0A5F4DEP4 1 EQUAL 513 EQUAL Reactome DB_ID: 10097373 1 DNA DSBs:MRN [nucleoplasm] DNA DSBs:MRN Reactome DB_ID: 75165 1 DNA double-strand break ends [nucleoplasm] DNA double-strand break ends Reactome DB_ID: 10044116 1 MRN [nucleoplasm] MRN Reactome DB_ID: 10044114 1 UniProt:J9NSC8 UniProt J9NSC8 1 EQUAL 754 EQUAL Reactome DB_ID: 10039267 1 UniProt:F1PUK4 UniProt F1PUK4 1 EQUAL 708 EQUAL Reactome DB_ID: 10039271 1 UniProt:J9P3S4 UniProt J9P3S4 1 EQUAL 1312 EQUAL Reactome Database ID Release 82 10044116 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10044116 Reactome R-CFA-75164 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-75164.1 Reactome Database ID Release 82 10097373 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10097373 Reactome R-CFA-3785763 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3785763.1 Reactome Database ID Release 82 10110457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110457 Reactome R-CFA-5682055 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682055.1 Reactome DB_ID: 113582 1 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 Reactome DB_ID: 10039288 1 DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 Reactome DB_ID: 10039286 1 O-phospho-L-serine at 1981 (in Homo sapiens) 1981 EQUAL N6-acetyl-L-lysine at 3016 (in Homo sapiens) 3016 EQUAL 1 EQUAL 3056 EQUAL Reactome DB_ID: 10039263 1 1 EQUAL 513 EQUAL Reactome DB_ID: 10039280 1 DNA DSBs:p-MRN [nucleoplasm] DNA DSBs:p-MRN Reactome DB_ID: 75165 1 Reactome DB_ID: 10039278 1 p-MRN [nucleoplasm] p-MRN Reactome DB_ID: 10039276 1 O-phospho-L-serine at 343 (in Homo sapiens) 343 EQUAL 1 EQUAL 754 EQUAL Reactome DB_ID: 10039267 1 1 EQUAL 708 EQUAL Reactome DB_ID: 10039271 1 1 EQUAL 1312 EQUAL Reactome Database ID Release 82 10039278 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039278 Reactome R-CFA-5682166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682166.1 Reactome Database ID Release 82 10039280 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039280 Reactome R-CFA-5682175 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682175.1 Reactome Database ID Release 82 10039288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039288 Reactome R-CFA-5682162 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5682162.1 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10110457 GO 0004674 GO molecular function Reactome Database ID Release 82 10110523 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110523 Reactome Database ID Release 82 10110525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10110525 Reactome R-CFA-5693598 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5693598.1 NSB1 (NBN) is a component of the MRN (MRE11:RAD50:NBN) complex which acts early in homologous recombination repair (HRR) during recognition and resection of double-strand breaks (DSBs). ATM-mediated phosphorylation of NBN at serine residue S343 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR (Lim et al. 2000, Gatei et al. 2000, Lee and Paull 2004). The phosphorylation of NBN by ATM may be enhanced by the presence of BRCA1 (Foray et al. 2003). 12773400 Pubmed 2003 A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. Foray, N Marot, D Gabriel, A Randrianarison, V Perricaudet, M Ashworth, A Jeggo, P EMBO J 22:2860-71 10766245 Pubmed 2000 ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway Lim, D S Kim, S T Xu, B Maser, RS Lin, J Petrini, JH Kastan, M B Nature 404:613-7 10802669 Pubmed 2000 ATM-dependent phosphorylation of nibrin in response to radiation exposure Gatei, M Young, D Cerosaletti, K M Desai-Mehta, A Spring, K Kozlov, S Lavin, M F Gatti, R A Concannon, P Khanna, K Nat. Genet. 25:115-9 15064416 Pubmed 2004 Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex Lee, Ji-Hoon Paull, Tanya T Science 304:93-6 12861053 Pubmed 2003 Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Lee, JH Xu, B Lee, CH Ahn, JY Song, MS Lee, H Canman, CE Lee, JS Kastan, MB Lim, DS Mol Cancer Res 1:674-81 inferred by electronic annotation IEA GO IEA