BioPAX pathway converted from "USP43 deISGylates ISG:K164,ISG:K168-PCNA" in the Reactome database. USP43 deISGylates ISG:K164,ISG:K168-PCNA USP43 deISGylates ISG:K164,ISG:K168-PCNA This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10112945 1 nucleoplasm GO 0005654 USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10112939 1 UniProt:E1BKF4 USP43 Reactome http://www.reactome.org Bos taurus NCBI Taxonomy 9913 UniProt E1BKF4 Chain Coordinates 1 EQUAL 1123 EQUAL Reactome DB_ID: 10112943 1 ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10076341 1 RPA heterotrimer [nucleoplasm] RPA heterotrimer Reactome DB_ID: 10072893 1 UniProt:Q3SZ11 RPA3 UniProt Q3SZ11 1 EQUAL 121 EQUAL Reactome DB_ID: 10072909 1 UniProt:Q2KI86 RPA2 UniProt Q2KI86 1 EQUAL 270 EQUAL Reactome DB_ID: 10072889 1 Ghost homologue of RPA1 [nucleoplasm] Ghost homologue of RPA1 Reactome Database ID Release 79 10076341 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10076341 Reactome R-BTA-68462 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68462.1 Reactome DB_ID: 10112941 1 ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] ISG:K164,ISG:K168-PCNA homotrimer Reactome DB_ID: 10076350 2 UniProt:Q3ZBW4 PCNA UniProt Q3ZBW4 1 EQUAL 261 EQUAL Reactome DB_ID: 10112929 1 ISG:K164,ISG:K168-PCNA [nucleoplasm] ISG:K164,ISG:K168-PCNA Reactome DB_ID: 10112927 1 Inter-chain Crosslink via N6-glycyl-L-lysine at 164 and 157 (in Homo sapiens) 164 EQUAL N6-glycyl-L-lysine ChEBI 30777 modification Inter-chain Crosslink via N6-glycyl-L-lysine at 168 and 157 (in Homo sapiens) 168 EQUAL 1 EQUAL 261 EQUAL Reactome DB_ID: 10112923 2 UniProt:O02741 ISG15 UniProt O02741 Inter-chain Crosslink via N6-glycyl-L-lysine at 157 and 164 (in Homo sapiens) 157 EQUAL ChEBI 24411 modification 2 EQUAL 157 EQUAL Reactome Database ID Release 79 10112929 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112929 Reactome R-BTA-5653767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653767.1 Reactome Database ID Release 79 10112941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112941 Reactome R-BTA-5653771 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653771.1 Reactome DB_ID: 10072976 1 RFC Heteropentamer [nucleoplasm] RFC Heteropentamer Reactome DB_ID: 10072974 1 UniProt:A0A3Q1N5S1 RFC1 UniProt A0A3Q1N5S1 1 EQUAL 1148 EQUAL Reactome DB_ID: 10072964 1 UniProt:A0A3Q1M1J3 RFC4 UniProt A0A3Q1M1J3 1 EQUAL 363 EQUAL Reactome DB_ID: 10072960 1 UniProt:A0A3Q1LY33 RFC5 UniProt A0A3Q1LY33 1 EQUAL 340 EQUAL Reactome DB_ID: 10072970 1 Ghost homologue of RFC2 [nucleoplasm] Ghost homologue of RFC2 Reactome DB_ID: 10072968 1 UniProt:Q2TBV1 RFC3 UniProt Q2TBV1 1 EQUAL 356 EQUAL Reactome Database ID Release 79 10072976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10072976 Reactome R-BTA-68436 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68436.1 Reactome DB_ID: 10112898 1 Ghost homologue of TLS-DNA Template [nucleoplasm] Ghost homologue of TLS-DNA Template Reactome Database ID Release 79 10112943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112943 Reactome R-BTA-5653772 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653772.1 Reactome Database ID Release 79 10112945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112945 Reactome R-BTA-5653781 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653781.1 Reactome DB_ID: 113518 2 water [ChEBI:15377] water ChEBI 15377 Reactome DB_ID: 10112949 1 PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] PCNA:RPA:RFC:TLS-DNA Template Reactome DB_ID: 10076341 1 Reactome DB_ID: 10079364 1 PCNA homotrimer [nucleoplasm] PCNA homotrimer Reactome DB_ID: 10076350 3 1 EQUAL 261 EQUAL Reactome Database ID Release 79 10079364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10079364 Reactome R-BTA-68440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68440.1 Reactome DB_ID: 10072976 1 Reactome DB_ID: 10112898 1 Reactome Database ID Release 79 10112949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112949 Reactome R-BTA-5653782 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653782.1 Reactome DB_ID: 10112951 2 2 EQUAL 157 EQUAL Reactome DB_ID: 10112939 1 1 EQUAL 1123 EQUAL PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10112945 GO 0019785 GO molecular function Reactome Database ID Release 79 10112952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112952 Reactome Database ID Release 79 10112954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10112954 Reactome R-BTA-5653786 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5653786.1 USP43 acts as an ISG15 protease to cleave ISG15 from lysines K164 and K168 of PCNA, thus deISGylating PCNA (Park et al. 2014). 24768535 Pubmed 2014 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis Park, Jung Mi Yang, Seung Wook Yu, Kyung Ryun Ka, Seung Hyun Lee, Seong Won Seol, Jae Hong Jeon, Young Joo Chung, Chin Ha Mol. Cell 54:626-38 inferred by electronic annotation IEA GO IEA