BioPAX pathway converted from "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" in the Reactome database.

2.7.11

monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 10121477

cytosolGO0005829

UniProt:I3LGX5CERT1

Reactomehttp://www.reactome.orgSus scrofa

NCBI Taxonomy9823UniProtI3LGX5

O-phospho-L-serine at 132 (in Homo sapiens)

132

EQUAL

O-phospho-L-serine [MOD:00046]

Chain Coordinates

EQUAL

624

EQUAL

Reactome DB_ID: 113592

ATP(4-) [ChEBI:30616]

ATP(4-)

Adenosine 5'-triphosphateatpATP

ChEBI30616

Reactome DB_ID: 29370

ADP(3-) [ChEBI:456216]

ADP(3-)

ADP trianion5'-O-[(phosphonatooxy)phosphinato]adenosineADP

ChEBI456216

Reactome DB_ID: 10121500

O-phospho-L-serine at 132 (in Homo sapiens)

132

EQUAL

O-phospho-L-serine at unknown position

O-phospho-L-threonine at unknown position

O-phospho-L-threonine [MOD:00047]

EQUAL

624

EQUAL

PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 10121504

UniProt:F1SDH5CSNK1G2

UniProtF1SDH5

EQUAL

415

EQUAL

GO0004674

GO molecular function

Reactome Database ID Release 7510121505Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10121505Reactome Database ID Release 7510121507Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10121507ReactomeR-SSC-429714

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-429714.1Cytosolic CSNK1G2 (casein kinase 1, gamma 2) catalyzes the phosphorylation of multiple serine and threonine residues of “CERT” (ceramide transfer protein) already phosphorylated on serine-132 (Tomishige et al. 2009). This reaction has the effect of inhibiting ceramide transport from the endoplasmic reticulum to the Golgi apparatus as multiphospho-CERT is unable to bind ceramides or associate with the Golgi membrane.

19005213Pubmed2009Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelinTomishige, NKumagai, KKusuda, JNishijima, MHanada, KMol Biol Cell 20:348-57inferred by electronic annotationIEAGOIEA