BioPAX pathway converted from "PHF8 demethylates histone H4K20me1" in the Reactome database.PHF8 demethylates histone H4K20me1

PHF8 demethylates histone H4K20me1

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 113671

nucleoplasmGO0005654

2-oxoglutarate(2-) [ChEBI:16810]

2-oxoglutarate(2-)

2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarate

Reactomehttp://www.reactome.orgChEBI16810

Reactome DB_ID: 10143346

PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]

PHF8:Nucleosome with H3K4me2/3:H4K20me1

Reactome DB_ID: 10143334

Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]

Nucleosome with H3K4me2/3:H4K20me1

Converted from EntitySet in Reactome

Reactome DB_ID: 10095315

Histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity

Reactome DB_ID: 10143332

UniProt:P62802

Sus scrofa

NCBI Taxonomy9823UniProtP62802

N6-methyl-L-lysine at 21 (in Homo sapiens)

EQUAL

N6-methyl-L-lysine [MOD:00085]

Chain Coordinates

EQUAL

103

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 10143329

H3K4me2/3 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity

Converted from EntitySet in Reactome

Reactome DB_ID: 10092108

Histone H2B [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity

Reactome Database ID Release 7510143334Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143334ReactomeR-SSC-2245190

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2245190.1

Reactome DB_ID: 10143344

PHF8:Fe2+ [nucleoplasm]

PHF8:Fe2+

Reactome DB_ID: 10143338

UniProt:F1RUG9PHF8

UniProtF1RUG9

EQUAL

1024

EQUAL

Reactome DB_ID: 111793

iron(2+) [ChEBI:29033]

iron(2+)

FE (II) IONFe(2+)Fe(II)Ferrous ionFe2+iron ion(2+)

ChEBI29033Reactome Database ID Release 7510143344Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143344ReactomeR-SSC-2245219

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2245219.1Reactome Database ID Release 7510143346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143346ReactomeR-SSC-2172686

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2172686.1

Reactome DB_ID: 113685

dioxygen [ChEBI:15379]

dioxygen

ChEBI15379

Reactome DB_ID: 10143350

PHF8:Nucleosome with H3K4me2/3 [nucleoplasm]

PHF8:Nucleosome with H3K4me2/3

Reactome DB_ID: 10143348

Nucleosome with H3K4me2/3 [nucleoplasm]

Nucleosome with H3K4me2/3

Reactome DB_ID: 10095277

EQUAL

103

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 10095315

Converted from EntitySet in Reactome

Reactome DB_ID: 10143329

Converted from EntitySet in Reactome

Reactome DB_ID: 10092108

Reactome Database ID Release 7510143348Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143348ReactomeR-SSC-2245194

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2245194.1

Reactome DB_ID: 10143344

Reactome Database ID Release 7510143350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143350ReactomeR-SSC-2172681

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2172681.1

Reactome DB_ID: 29478

formaldehyde [ChEBI:16842]

formaldehyde

ChEBI16842

Reactome DB_ID: 159939

succinate(2-) [ChEBI:30031]

succinate(2-)

succinate(-)OOC-CH2-CH2-COO(-)butanedioic acid, ion(2-)butanedioate

ChEBI30031

Reactome DB_ID: 159942

carbon dioxide [ChEBI:16526]

carbon dioxide

ChEBI16526PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 10143346

GO0035575

GO molecular function

Reactome Database ID Release 7510143351Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143351Reactome Database ID Release 7510143353Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10143353ReactomeR-SSC-2172678

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2172678.1PHF8, a PHD and Jumonji C domain-containing protein, is recruited to chromatin by binding to dimethylated or trimethylated histone H3 - H3K4me2 and/or H3K4me3. PHF8 demethylates monomethylated histone H4, H4K20me1, a docking site for the condesin II complex (Liu et al. 2010).

20622854Pubmed2010PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progressionLiu, WTanasa, BTyurina, OVZhou, TYGassmann, RLiu, WTOhgi, KABenner, CGarcia-Bassets, IAggarwal, AKDesai, ADorrestein, PCGlass, CKRosenfeld, MGNature 466:508-12inferred by electronic annotationIEAGOIEA