BioPAX pathway converted from "Alternative endo-mannosidase I route" in the Reactome database.

3.2.1.130

Alternative endo-mannosidase I route

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 964754

Golgi lumenGO0005796

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59084]

Reactomehttp://www.reactome.orgChEBI59084

Reactome DB_ID: 964744

N-{alpha-Man-(1->4)-alpha-Man-(1->4)-alpha-Man-(1->3)-[alpha-Man-(1->3)-[alpha-Man-(1->4)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59089]

N-{alpha-Man-(1->4)-alpha-Man-(1->4)-alpha-Man-(1->3)-[alpha-Man-(1->3)-[alpha-Man-(1->4)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue

ChEBI59089

Reactome DB_ID: 964746

alpha-D-glucose [ChEBI:17925]

alpha-D-glucose

ChEBI17925PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Converted from EntitySet in Reactome

Reactome DB_ID: 10229681

Golgi membraneGO0000139

Homologues of MANEA [Golgi membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitymaneal [Golgi membrane]manea [Golgi membrane]

Danio rerio

NCBI Taxonomy7955UniProtQ1L8D2UniProtE7EYY9GO0004569

GO molecular function

Reactome Database ID Release 7510229682Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229682Reactome Database ID Release 7510229684Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10229684ReactomeR-DRE-964759

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-964759.1Cells exposed to castanospermine or 1-deoxynojirimycin (inhibitors of the glucosidase enzymes GCS1 and GANAB), are still able to carry out glycosylation and produce complex glycans. This is due to the existence of an alternative route catalyzed by the enzyme endomannosidase (Moore and Spiro, 1990).<br>Glycoproteins that pass through this route probably skip or have a reduced interaction with the Calnexin/Calreticulin cycle, and are transported to the cis-golgi through a route that has not been described yet (probably through the general ER to Golgi flow). Here, the Endomannosidase enzyme, which resides on the Golgi membrane (Hardt et al 2005; Hamilton et al 2005) is able to remove the tri-, di-, or mono-glucose substituted mannose on branch A, leading to a deglucosylated N-glycan structure (Lubas and Spiro, 1988).

15760709Pubmed2005Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane proteinHardt, BVölker, CMundt, SSalska-Navarro, MHauptmann, MBause, EBiochimie 87:169-7915677381Pubmed2005Intact {alpha}-1,2-endomannosidase is a typical type II membrane proteinHamilton, SRLi, HWischnewski, HPrasad, AKerley-Hamilton, JSMitchell, TWalling, AJDavidson, RCWildt, SGerngross, TUGlycobiology 15:615-242165493Pubmed1990Demonstration that Golgi endo-alpha-D-mannosidase provides a glucosidase-independent pathway for the formation of complex N-linked oligosaccharides of glycoproteinsMoore, SESpiro, RGJ Biol Chem 265:13104-123346233Pubmed1988Evaluation of the role of rat liver Golgi endo-alpha-D-mannosidase in processing N-linked oligosaccharidesLubas, WASpiro, RGJ Biol Chem 263:3990-8inferred by electronic annotationIEAGOIEA