BioPAX pathway converted from "Fibrillin-1 binds integrins" in the Reactome database.Fibrillin-1 binds integrinsFibrillin-1 binds integrinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 102551071plasma membraneGO0005886Fibrilin-binding integrins [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactomehttp://www.reactome.orgReactome DB_ID: 102432181extracellular regionGO0005576Fibrillin-1 [extracellular region]Fibrillin-1Reactome DB_ID: 102551091Fibrilin-1:Fibrilin-binding integrins [plasma membrane]Fibrilin-1:Fibrilin-binding integrinsConverted from EntitySet in ReactomeReactome DB_ID: 102551071Reactome DB_ID: 102432181Danio rerioNCBI Taxonomy7955Reactome Database ID Release 7510255109Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10255109ReactomeR-DRE-23962001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2396200.1Reactome Database ID Release 7510255111Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10255111ReactomeR-DRE-23280371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2328037.1Fibrillin-1 splice variants that include the RGD sequence located in the fourth 8-cysteine domain mediate cell adhesion, binding integrin alphaVbeta3 (Pfaff et al. 1996), alpha5beta1 (Bax et al. 2003) and alphaVbeta6 (Jovanovic et al. 2008). AlphaVbeta3 has the highest affinity for fibrillin-1. Integrin alphaVbeta3 is a high-affinity fibrillin-1 receptor (K(d) approximately 40 nM), whereas integrins alphaVbeta6 and alpha5beta1 show moderate-affinity (K(d) approximately 450 nM) and low-affinity (K(d) >1 microM) binding respectively (Jovanovic et al. 2008). 12807887Pubmed2003Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrinsBax, DVBernard, SELomas, AMorgan, AHumphries, JShuttleworth, CAHumphries, MartinKielty, CMJ Biol Chem 278:34605-168617364Pubmed1996Cell adhesion and integrin binding to recombinant human fibrillin-1Pfaff, MReinhardt, D PSakai, L YTimpl, RFEBS Lett. 384:247-5018363569Pubmed2008Fibrillin-integrin interactions in health and diseaseJovanovic, JIqbal, SJensen, SMardon, HHandford, Penny ABiochem Soc Trans 36:257-62inferred by electronic annotationIEAGOIEA