BioPAX pathway converted from "RUNX3 binds EP300" in the Reactome database.RUNX3 binds EP300

RUNX3 binds EP300

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 10220164

nucleoplasmGO0005654

UniProt:A0A286Y8K1

Reactomehttp://www.reactome.orgDanio rerio

NCBI Taxonomy7955UniProtA0A286Y8K1

Chain Coordinates

EQUAL

2414

EQUAL

Reactome DB_ID: 10279273

RUNX3:CBFB [nucleoplasm]

RUNX3:CBFB

Reactome DB_ID: 10279271

UniProt:F6NM27

UniProtF6NM27

EQUAL

415

EQUAL

Reactome DB_ID: 10279252

UniProt:A0A140LGT1

UniProtA0A140LGT1

EQUAL

182

EQUAL

Reactome Database ID Release 7010279273Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10279273ReactomeR-DRE-8865463

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8865463.1

Reactome DB_ID: 10284763

RUNX3:CBFB:EP300 [nucleoplasm]

RUNX3:CBFB:EP300

Reactome DB_ID: 10220164

EQUAL

2414

EQUAL

Reactome DB_ID: 10279273

Reactome Database ID Release 7010284763Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10284763ReactomeR-DRE-8951952

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8951952.1Reactome Database ID Release 7010284765Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10284765ReactomeR-DRE-8951951

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8951951.1The histone acetyltransferase EP300 (p300) forms a complex with RUNX3, presumably bound to CBFB (Jin et al. 2004, Lee et al. 2013). EP300 can also form a complex with other RUNX family members, RUNX1 and RUNX2 (Jin et al. 2004).

24229708Pubmed2013Runx3 inactivation is a crucial early event in the development of lung adenocarcinomaLee, You-SoubLee, Jung-WonJang, Ju-WonChi, Xin-ZiKim, Jang-HyunLi, Ying-HuiKim, Min-KyuKim, Da-MiChoi, Byeung-SubKim, EGChung, Jin-HaengLee, Ok-JunLee, You-MieSuh, Joo-WonChuang, Linda Shyue HueyIto, YoshiakiBae, Suk-ChulCancer Cell 24:603-1615138260Pubmed2004Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradationJin, Yun-HyeJeon, Eun-JooLi, Qing-LinLee, Yong HeeChoi, Joong-KookKim, Wun-JaeLee, Kwang-YoulBae, Suk-ChulJ. Biol. Chem. 279:29409-17inferred by electronic annotationIEAGOIEA