BioPAX pathway converted from "RUNX3 regulates CDKN1A transcription" in the Reactome database.RUNX3 regulates CDKN1A transcriptionRUNX3 regulates CDKN1A transcriptionThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RUNX3 binds SMAD3 and SMAD4RUNX3 binds SMAD3 and SMAD4This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 102936501nucleoplasmGO0005654p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]p-2S-SMAD3:p-2S-SMAD3:SMAD4Reactome DB_ID: 102019492UniProt:Q8AY15smad3aReactomehttp://www.reactome.orgDanio rerioNCBI Taxonomy7955UniProtQ8AY15O-phospho-L-serine at 423 (in Homo sapiens)423EQUALO-phospho-L-serine [MOD:00046]O-phospho-L-serine at 425 (in Homo sapiens)425EQUALChain Coordinates1EQUAL425EQUALReactome DB_ID: 102019451UniProt:F1QS48smad4aUniProtF1QS481EQUAL552EQUALReactome Database ID Release 7510293650Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293650ReactomeR-DRE-88781531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8878153.1Reactome DB_ID: 102914221UniProt:F6NM27runx3UniProtF6NM271EQUAL415EQUALReactome DB_ID: 102936521RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4Reactome DB_ID: 102936501Reactome DB_ID: 1029142211EQUAL415EQUALReactome Database ID Release 7510293652Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293652ReactomeR-DRE-88781461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8878146.1Reactome Database ID Release 7510293654Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293654ReactomeR-DRE-88781431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8878143.1RUNX3 binds the complex of SMAD3 and SMAD4, formed in response to TGF-beta (TGFB1) signaling (Hanai et al. 1999, Chi et al. 2005).10531362Pubmed1999Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoterHanai, JChen, L FKanno, TOhtani-Fujita, NKim, W YGuo, W HImamura, TIshidou, YFukuchi, MShi, M JStavnezer, JKawabata, MMiyazono, KIto, YJ. Biol. Chem. 274:31577-8216135801Pubmed2005RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMADChi, Xin-ZiYang, Jeung-OokLee, Kwang-YoulIto, KoseiSakakura, ChoheiLi, Qing-LinKim, Hye-RyunCha, Eun-JeungLee, Yong-HeeKaneda, AtsushiUshijima, ToshikazuKim, Wun-JaeIto, YoshiakiBae, Suk-ChulMol. Cell. Biol. 25:8097-107inferred by electronic annotationIEAGOIEARUNX3 binds ZFHX3RUNX3 binds ZFHX3This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1029142211EQUAL415EQUALReactome DB_ID: 102936431UniProt:A0A0R4ISP1zfhx3UniProtA0A0R4ISP11EQUAL3703EQUALReactome DB_ID: 102936451RUNX3:ZFHX3 [nucleoplasm]RUNX3:ZFHX3Reactome DB_ID: 1029142211EQUAL415EQUALReactome DB_ID: 1029364311EQUAL3703EQUALReactome Database ID Release 7510293645Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293645ReactomeR-DRE-88781201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8878120.1Reactome Database ID Release 7510293647Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293647ReactomeR-DRE-88781171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8878117.1In response to TGF-beta (TGFB1) signaling, RUNX3 binds to the homeobox transcription factor and tumor suppressor ZFHX3 (ATBF1). The exact mechanism and regulation of RUNX3 and ATBF1 binding is not known (Mabuchi et al. 2010).20599712Pubmed2010Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transductionMabuchi, MotoshiKataoka, HiromiMiura, YutakaKim, Tae-SunKawaguchi, MakotoEbi, MasahideTanaka, MamoruMori, YoshinoriKubota, EijiMizushima, TakashiShimura, TakayaMizoshita, TsutomuTanida, SatoshiKamiya, TakeshiAsai, KJoh, TakashiBiochem. Biophys. Res. Commun. 398:321-5inferred by electronic annotationIEAGOIEAACTIVATIONReactome Database ID Release 7510293648Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10293648Reactome DB_ID: 10201726extracellular regionGO0005576Dimeric TGFB1 [extracellular region]Dimeric TGFB1Reactome DB_ID: 102017242UniProt:F1R741tgfb1aUniProtF1R741279EQUAL390EQUALReactome Database ID Release 7510201726Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10201726ReactomeR-DRE-1708521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-170852.1RUNX3 binds TP53RUNX3 binds TP53This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1029142211EQUAL415EQUALReactome DB_ID: 102590561TP53 Tetramer [nucleoplasm]TP53 TetramerReactome DB_ID: 102579594UniProt:P79734tp53UniProtP797341EQUAL393EQUALReactome Database ID Release 7510259056Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10259056ReactomeR-DRE-32091941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3209194.1Reactome DB_ID: 102970001RUNX3:TP53 tetramer [nucleoplasm]RUNX3:TP53 tetramerReactome DB_ID: 1029142211EQUAL415EQUALReactome DB_ID: 102590561Reactome Database ID Release 7510297000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10297000ReactomeR-DRE-89521231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8952123.1Reactome Database ID Release 7510297002Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10297002ReactomeR-DRE-89521281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8952128.1RUNX3 can bind to TP53 (p53). The interaction involves the C-termini of both RUNX3 and TP53. RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21). RUNX3 may also interact with phosphorylated ATM kinase in response to DNA damage and facilitate ATM-mediated phosphorylation and stabilization of TP53 (Yamada et al. 2010).20353948Pubmed2010RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53Yamada, ChizuOzaki, ToshinoriAndo, KSuenaga, YusukeInoue, Ken-ichiIto, YoshiakiOkoshi, RintaroKageyama, HajimeKimura, HidekiMiyazaki, MasaruNakagawara, AkiraJ. Biol. Chem. 285:16693-703inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510305831Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10305831ReactomeR-DRE-89418551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-8941855.1RUNX3 contributes to the upregulation of the CDKN1A (p21) gene transcription in response to TGF-beta (TGFB1) signaling. RUNX3 binds to SMAD3 and SMAD4, and cooperates with the activated SMAD3:SMAD4 complex in transactivation of CDKN1A. Runx3 knockout mice exhibit decreased sensitivity to TGF-beta and develop gastric epithelial hyperplasia (Chi et al. 2005). In response to TGF-beta signaling, the CBFB:RUNX3 complex binds to the tumor suppressor ZFHX3 (ATBF1) and, through an unknown mechanism, this complex positively regulates the CDKN1A transcription (Mabuchi et al. 2010).<br>In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010).inferred by electronic annotationIEAGOIEA