BioPAX pathway converted from "SPAM1 Binds Hyaluronic Acid" in the Reactome database. SPAM1 Binds Hyaluronic Acid SPAM1 Binds Hyaluronic Acid This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 1297302 1 extracellular region GO 0005576 hyaluronic acid [ChEBI:16336] hyaluronic acid Reactome http://www.reactome.org ChEBI 16336 Reactome DB_ID: 10306269 1 plasma membrane GO 0005886 UniProt:Q8MI02 SPAM1 Sus scrofa NCBI Taxonomy 9823 UniProt Q8MI02 Chain Coordinates 36 EQUAL 490 EQUAL Reactome DB_ID: 10306271 1 SPAM1:Hyaluronic acid [extracellular region] SPAM1:Hyaluronic acid Reactome DB_ID: 1297302 1 Reactome DB_ID: 10306269 1 36 EQUAL 490 EQUAL Reactome Database ID Release 82 10306271 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306271 Reactome R-SSC-1297353 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-1297353.1 Reactome Database ID Release 82 10306273 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306273 Reactome R-SSC-2534346 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SSC-2534346.1 GO 0035036 GO biological process The fertilizing spermatozoon must penetrate the surrounding cumulus mass, (or cumulus oophorus), consisting of follicular cells dispersed in a polymerized matrix composed mainly of hyaluronic acid. 8195297 Pubmed 1994 A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg Lin, Y Mahan, K Lathrop, WF Myles, DG Primakoff, P J Cell Biol 125:1157-63 inferred by electronic annotation IEA GO IEA