BioPAX pathway converted from "POLZ extends translesion synthesis" in the Reactome database.

2.7.7.7

POLZ extends translesion synthesis

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 30555

nucleoplasmGO0005654

2'-deoxyribonucleoside triphosphate [ChEBI:16516]

2'-deoxyribonucleoside triphosphate

Reactomehttp://www.reactome.orgChEBI16516

Reactome DB_ID: 10314065

POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm]

POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template

Reactome DB_ID: 10314063

POLZ [nucleoplasm]

POLZ

Reactome DB_ID: 10314057

UniProt:F7BUY5

Xenopus tropicalis

NCBI Taxonomy8364UniProtF7BUY5

Chain Coordinates

EQUAL

3130

EQUAL

Reactome DB_ID: 10314061

UniProt:Q28H85mad2l2

UniProtQ28H85

EQUAL

211

EQUAL

Reactome Database ID Release 7510314063Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314063ReactomeR-XTR-110279

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-110279.1

Reactome DB_ID: 10314050

REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm]

REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template

Reactome DB_ID: 10314027

UniProt:F7AWG2rev1

UniProtF7AWG2

EQUAL

1251

EQUAL

Reactome DB_ID: 10314048

MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm]

MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA

Reactome DB_ID: 10314046

Ghost homologue of (AP:Cyt)-DNA Template [nucleoplasm]

Ghost homologue of (AP:Cyt)-DNA Template

Reactome DB_ID: 10314036

MonoUb:K164-PCNA:RPA:RFC [nucleoplasm]

MonoUb:K164-PCNA:RPA:RFC

Reactome DB_ID: 10307260

RFC Heteropentamer [nucleoplasm]

RFC Heteropentamer

Reactome DB_ID: 10307242

UniProt:F6Y531

UniProtF6Y531

EQUAL

340

EQUAL

Reactome DB_ID: 10307254

UniProt:F6W0K5

UniProtF6W0K5

EQUAL

354

EQUAL

Reactome DB_ID: 10307246

UniProt:F6RNS6rfc4

UniProtF6RNS6

EQUAL

363

EQUAL

Reactome DB_ID: 10307258

UniProt:F7C9M5rfc1

UniProtF7C9M5

EQUAL

1148

EQUAL

Reactome DB_ID: 10307250

UniProt:F7ANQ6rcbtb2

UniProtF7ANQ6

EQUAL

356

EQUAL

Reactome Database ID Release 7510307260Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307260ReactomeR-XTR-68436

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68436.1

Reactome DB_ID: 10314034

MonoUb:K164-PCNA homotrimer [nucleoplasm]

MonoUb:K164-PCNA homotrimer

Reactome DB_ID: 10314032

MonoUb:K164-PCNA [nucleoplasm]

MonoUb:K164-PCNA

Reactome DB_ID: 10314030

UniProt:Q66KJ8pcna

UniProtQ66KJ8

ubiquitinylated lysine at 164 (in Homo sapiens)

164

EQUAL

ubiquitinylated lysine [MOD:01148]

EQUAL

261

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 10307085

Ub [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityUBC(77-152) [nucleoplasm]UBB(153-228) [nucleoplasm]UBC(457-532) [nucleoplasm]UBB(1-76) [nucleoplasm]UBC(609-684) [nucleoplasm]UBC(381-456) [nucleoplasm]UBC(1-76) [nucleoplasm]UBB(77-152) [nucleoplasm]UBC(533-608) [nucleoplasm]UBC(153-228) [nucleoplasm]uba52 [nucleoplasm]UBC(229-304) [nucleoplasm]UBC(305-380) [nucleoplasm]

UniProtF7DNS3UniProtF6VNK4UniProtQ6AZL4Reactome Database ID Release 7510314032Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314032ReactomeR-XTR-5651984

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5651984.1

Reactome DB_ID: 10307268

EQUAL

261

EQUAL

Reactome Database ID Release 7510314034Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314034ReactomeR-XTR-5651993

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5651993.1

Reactome DB_ID: 10307309

RPA heterotrimer [nucleoplasm]

RPA heterotrimer

Reactome DB_ID: 10306970

UniProt:Q5FW17rpa1

UniProtQ5FW17

EQUAL

616

EQUAL

Reactome DB_ID: 10306974

UniProt:B0JZ11rpa3

UniProtB0JZ11

EQUAL

121

EQUAL

Reactome DB_ID: 10306980

UniProt:Q6DFS2rpa2

UniProtQ6DFS2

EQUAL

270

EQUAL

Reactome Database ID Release 7510307309Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307309ReactomeR-XTR-68462

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68462.1Reactome Database ID Release 7510314036Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314036ReactomeR-XTR-5651997

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5651997.1Reactome Database ID Release 7510314048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314048ReactomeR-XTR-5652038

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5652038.1Reactome Database ID Release 7510314050Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314050ReactomeR-XTR-110285

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-110285.1Reactome Database ID Release 7510314065Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314065ReactomeR-XTR-5652152

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5652152.1

Reactome DB_ID: 113541

diphosphoric acid [ChEBI:29888]

diphosphoric acid

ChEBI29888

Reactome DB_ID: 10314069

REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm]

REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template

Reactome DB_ID: 10314027

EQUAL

1251

EQUAL

Reactome DB_ID: 10314067

Ghost homologue of (AP:Cyt-mispaireddNMPs)-DNA Template [nucleoplasm]

Ghost homologue of (AP:Cyt-mispaireddNMPs)-DNA Template

Reactome DB_ID: 10314036

Reactome Database ID Release 7510314069Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314069ReactomeR-XTR-5652153

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5652153.1

Reactome DB_ID: 10314063

PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 10314065

GO0003887

GO molecular function

Reactome Database ID Release 7510314070Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314070Reactome Database ID Release 7510314072Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314072ReactomeR-XTR-110311

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-110311.1After REV1 inserts a nucleotide directly opposite the template lesion, translesion synthesis (TLS) is continued by DNA polymerase zeta (POLZ), a complex of REV3L and MAD2L2 (REV3 and REV7 in yeast) (Nelson et al. 1996a, Neal et al. 2010). POLZ is a poorly processive enzyme in both yeast and humans and usually incorporates less than 30 nucleotides before it dissociates from the template. In human cells, the processivity of POLZ is increased in the presence of DNA polymerase delta (POLD) subunits POLD2 and POLD3, which act as accessory subunits for POLZ (Nelson et al. 1996b, Lee et al. 2014). POLZ is error-prone, especially in the context of TLS across AP (apurinic/apyrimidinic) sites, resulting in incorporation of mispaired dNTPs, which contributes to TLS-related mutagenesis (Shachar et al. 2009, Lee et al. 2014).

8751446Pubmed1996Deoxycytidyl transferase activity of yeast REV1 proteinNelson, J RLawrence, CWHinkle, D CNature 382:729-3124449906Pubmed2014Human Pol ? purified with accessory subunits is active in translesion DNA synthesis and complements Pol ? in cisplatin bypassLee, Young-SamGregory, Mark TYang, WeiProc. Natl. Acad. Sci. U.S.A. 111:2954-98658138Pubmed1996Thymine-thymine dimer bypass by yeast DNA polymerase zetaNelson, J RLawrence, CWHinkle, D CScience 272:1646-921143968Pubmed2010The role of hRev7, the accessory subunit of hPol?, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE)Neal, Jessica AFletcher, Kathryn LMcCormick, J JustinMaher, Veronica MBMC Cell Biol. 11:9719153606Pubmed2009Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammalsShachar, SigalZiv, OmerAvkin, SharonAdar, SheeraWittschieben, JohnReissner, ThomasChaney, StephenFriedberg, Errol CWang, ZhigangCarell, ThomasGeacintov, NicholasLivneh, ZviEMBO J. 28:383-93inferred by electronic annotationIEAGOIEA