BioPAX pathway converted from "FAAH hydrolyses AEA to AA and ETA" in the Reactome database. FAAH hydrolyses AEA to AA and ETA FAAH hydrolyses AEA to AA and ETA This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='' target='NEW'></a> Reactome DB_ID: 29356 1 cytosol GO 0005829 water [ChEBI:15377] water Reactome ChEBI 15377 Reactome DB_ID: 5693754 1 anandamide [ChEBI:2700] anandamide ChEBI 2700 Reactome DB_ID: 1498751 1 ethanolamine [ChEBI:16000] ethanolamine ChEBI 16000 Reactome DB_ID: 29768 1 arachidonate [ChEBI:32395] arachidonate (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (20:4n6) (5Z,8Z,11Z,14Z)-eicosatetraenoate ChEBI 32395 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 10322955 endoplasmic reticulum membrane GO 0005789 Homologues of FAAH [endoplasmic reticulum membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity FAAH [endoplasmic reticulum membrane] FAAH [endoplasmic reticulum membrane] Sus scrofa NCBI Taxonomy 9823 UniProt A0A287B2N9 UniProt Q9TUI8 GO 0017064 GO molecular function Reactome Database ID Release 82 10322956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: Reactome Database ID Release 82 10322958 Database identifier. Use this URL to connect to the web page of this instance in Reactome: Reactome R-SSC-5693742 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010). 19926788 Pubmed 2010 Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2 Kaczocha, Martin Glaser, Sherrye T Chae, Janiper Brown, Deborah A Deutsch, Dale G J. Biol. Chem. 285:2796-806 17015445 Pubmed 2006 A second fatty acid amide hydrolase with variable distribution among placental mammals Wei, Binqing Q Mikkelsen, Tarjei S McKinney, Michele K Lander, Eric S Cravatt, BF J. Biol. Chem. 281:36569-78 inferred by electronic annotation IEA GO IEA