BioPAX pathway converted from "BH2 binding can lead to eNOS uncoupling" in the Reactome database.BH2 binding can lead to eNOS uncouplingBH2 binding can lead to eNOS uncouplingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 14978571cytosolGO0005829D-erythro-7,8-dihydrobiopterin [ChEBI:15375]D-erythro-7,8-dihydrobiopterinReactomehttp://www.reactome.orgChEBI15375Reactome DB_ID: 103273681plasma membraneGO0005886p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4Reactome DB_ID: 2987015,6,7,8-tetrahydrobiopterin [ChEBI:15372]5,6,7,8-tetrahydrobiopterinChEBI15372Reactome DB_ID: 103273641p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]p-S1177-eNOS:CaM:HSP90:p-AKT1Reactome DB_ID: 103273571UniProt:F6SX68adam33Xenopus tropicalisNCBI Taxonomy8364UniProtF6SX68Chain Coordinates2EQUAL732EQUALReactome DB_ID: 103144171CALM1:4xCa2+ [cytosol]CALM1:4xCa2+Reactome DB_ID: 740164calcium(2+) [ChEBI:29108]calcium(2+)ChEBI29108Reactome DB_ID: 103088901UniProt:F6YF78esyt2UniProtF6YF782EQUAL149EQUALReactome Database ID Release 7510314417Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10314417ReactomeR-XTR-742941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74294.1Reactome DB_ID: 103273621p-S1177-eNOS dimer [plasma membrane]p-S1177-eNOS dimerReactome DB_ID: 298702Reactome DB_ID: 293862FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBI16238Reactome DB_ID: 711852ferroheme b [ChEBI:17627]ferroheme bChEBI17627Reactome DB_ID: 103273602UniProt:F6VMJ0nos3UniProtF6VMJ0O-phospho-L-serine at 1177 (in Homo sapiens)1177EQUALO-phospho-L-serine [MOD:00046]S-palmitoyl-L-cysteine at 15 (in Homo sapiens)15EQUALS-palmitoyl-L-cysteine [MOD:00115]S-palmitoyl-L-cysteine at 26 (in Homo sapiens)26EQUALN-myristoylglycine at 2 (in Homo sapiens)2EQUALN-myristoylglycine [MOD:00068]2EQUAL1203EQUALReactome DB_ID: 294261zinc(2+) [ChEBI:29105]zinc(2+)ChEBI29105Reactome DB_ID: 735242FMN [ChEBI:17621]FMNFlavin mononucleotideRiboflavin-5-phosphateChEBI17621Reactome Database ID Release 7510327362Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10327362ReactomeR-XTR-2035641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-203564.1Reactome DB_ID: 103248911UniProt:F6XP81akt1UniProtF6XP81O-phospho-L-threonine at 308 (in Homo sapiens)308EQUALO-phospho-L-threonine [MOD:00047]O-phospho-L-serine at 473 (in Homo sapiens)473EQUAL1EQUAL480EQUALReactome Database ID Release 7510327364Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10327364ReactomeR-XTR-2021211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-202121.1Reactome Database ID Release 7510327368Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10327368ReactomeR-XTR-14978301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1497830.1Reactome DB_ID: 298701Reactome DB_ID: 103565501p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane]p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2Reactome DB_ID: 1032735712EQUAL732EQUALReactome DB_ID: 14978571Reactome DB_ID: 103144171Reactome DB_ID: 103273621Reactome DB_ID: 103248911O-phospho-L-threonine at 308 (in Homo sapiens)308EQUALO-phospho-L-serine at 473 (in Homo sapiens)473EQUAL1EQUAL480EQUALReactome Database ID Release 7510356550Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10356550ReactomeR-XTR-14978891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1497889.1Reactome Database ID Release 7510356552Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10356552ReactomeR-XTR-14977961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-1497796.1The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).11879202Pubmed2002The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping studyVásquez-Vivar, JMartasek, PWhitsett, JJoseph, JacobKalyanaraman, BBiochem J 362:733-9inferred by electronic annotationIEAGOIEA