BioPAX pathway converted from "PHF8 demethylates histone H4K20me1" in the Reactome database.PHF8 demethylates histone H4K20me1PHF8 demethylates histone H4K20me1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1136711nucleoplasmGO00056542-oxoglutarate(2-) [ChEBI:16810]2-oxoglutarate(2-)2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarateReactomehttp://www.reactome.orgChEBI16810Reactome DB_ID: 103651861PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]PHF8:Nucleosome with H3K4me2/3:H4K20me1Reactome DB_ID: 103651841PHF8:Fe2+ [nucleoplasm]PHF8:Fe2+Reactome DB_ID: 103651781UniProt:F6QVQ5ano2Xenopus tropicalisNCBI Taxonomy8364UniProtF6QVQ5Chain Coordinates1EQUAL1024EQUALReactome DB_ID: 1117931iron(2+) [ChEBI:29033]iron(2+)FE (II) IONFe(2+)Fe(II)Ferrous ionFe2+iron ion(2+)ChEBI29033Reactome Database ID Release 7510365184Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365184ReactomeR-XTR-22452191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2245219.1Reactome DB_ID: 103651741Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]Nucleosome with H3K4me2/3:H4K20me1Converted from EntitySet in ReactomeReactome DB_ID: 103109012Histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome DB_ID: 103651692Ghost homologue of H3K4me2/3 [nucleoplasm]Ghost homologue of H3K4me2/3Reactome DB_ID: 103651722UniProt:Q28DR4UniProtQ28DR4N6-methyl-L-lysine at 21 (in Homo sapiens)21EQUALN6-methyl-L-lysine [MOD:00085]2EQUAL103EQUALConverted from EntitySet in ReactomeReactome DB_ID: 103075852Histone H2B [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome Database ID Release 7510365174Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365174ReactomeR-XTR-22451901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2245190.1Reactome Database ID Release 7510365186Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365186ReactomeR-XTR-21726861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2172686.1Reactome DB_ID: 1136851dioxygen [ChEBI:15379]dioxygenChEBI15379Reactome DB_ID: 294781formaldehyde [ChEBI:16842]formaldehydeChEBI16842Reactome DB_ID: 1599391succinate(2-) [ChEBI:30031]succinate(2-)succinate(-)OOC-CH2-CH2-COO(-)butanedioic acid, ion(2-)butanedioateChEBI30031Reactome DB_ID: 1599421carbon dioxide [ChEBI:16526]carbon dioxideChEBI16526Reactome DB_ID: 103651901PHF8:Nucleosome with H3K4me2/3 [nucleoplasm]PHF8:Nucleosome with H3K4me2/3Reactome DB_ID: 103651841Reactome DB_ID: 103651881Nucleosome with H3K4me2/3 [nucleoplasm]Nucleosome with H3K4me2/3Converted from EntitySet in ReactomeReactome DB_ID: 103109012Reactome DB_ID: 103651692Reactome DB_ID: 1031075922EQUAL103EQUALConverted from EntitySet in ReactomeReactome DB_ID: 103075852Reactome Database ID Release 7510365188Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365188ReactomeR-XTR-22451941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2245194.1Reactome Database ID Release 7510365190Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365190ReactomeR-XTR-21726811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2172681.1PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10365186GO0035575GO molecular functionReactome Database ID Release 7510365191Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365191Reactome Database ID Release 7510365193Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10365193ReactomeR-XTR-21726781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-2172678.1PHF8, a PHD and Jumonji C domain-containing protein, is recruited to chromatin by binding to dimethylated or trimethylated histone H3 - H3K4me2 and/or H3K4me3. PHF8 demethylates monomethylated histone H4, H4K20me1, a docking site for the condesin II complex (Liu et al. 2010). 20622854Pubmed2010PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progressionLiu, WTanasa, BTyurina, OVZhou, TYGassmann, RLiu, WTOhgi, KABenner, CGarcia-Bassets, IAggarwal, AKDesai, ADorrestein, PCGlass, CKRosenfeld, MGNature 466:508-12inferred by electronic annotationIEAGOIEA