BioPAX pathway converted from "Beta-catenin recruits TRRAP/KAT5 HAT components" in the Reactome database.Beta-catenin recruits TRRAP/KAT5 HAT componentsBeta-catenin recruits TRRAP/KAT5 HAT componentsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 103709921nucleoplasmGO0005654UniProt:F6Q5K9Reactomehttp://www.reactome.orgXenopus tropicalisNCBI Taxonomy8364UniProtF6Q5K9Chain Coordinates1EQUAL456EQUALReactome DB_ID: 103272521TCF/LEF:CTNNB1 [nucleoplasm]TCF/LEF:CTNNB1Reactome DB_ID: 103271201UniProt:Q28GC2ctnnb1UniProtQ28GC21EQUAL781EQUALConverted from EntitySet in ReactomeReactome DB_ID: 103272501TCF/LEF [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityfancd2 [nucleoplasm]abcb7 [nucleoplasm]UniProtF7BVL1UniProtF6WCX0Reactome Database ID Release 7510327252Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10327252ReactomeR-XTR-32995481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3299548.1Reactome DB_ID: 103074401UniProt:F7DYY3pde10aUniProtF7DYY31EQUAL513EQUALReactome DB_ID: 103709961UniProt:F6Y5Q7trrapUniProtF6Y5Q71EQUAL3859EQUALReactome DB_ID: 103709981TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5Reactome DB_ID: 1037099211EQUAL456EQUALReactome DB_ID: 103272521Reactome DB_ID: 1030744011EQUAL513EQUALReactome DB_ID: 1037099611EQUAL3859EQUALReactome Database ID Release 7510370998Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10370998ReactomeR-XTR-34511291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3451129.1Reactome Database ID Release 7510371000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10371000ReactomeR-XTR-34511531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-3451153.1Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).9843967Pubmed1998Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding proteinBauer, AHuber, OtmarKemler, RolfProc. Natl. Acad. Sci. U.S.A. 95:14787-9214695187Pubmed2003TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodelingFeng, YingLee, NanaFearon, Eric RCancer Res. 63:8726-3411080158Pubmed2000Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activityBauer, AChauvet, SophieHuber, OtmarUsseglio, FabriceRothbächer, UteAragnol, DeniseKemler, RolfPradel, JacquesEMBO J. 19:6121-3016510874Pubmed2006The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genesSierra, JoseYoshida, TomonoriJoazeiro, Claudio AJones, Katherine AGenes Dev. 20:586-60015829968Pubmed2005Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexesKim, Jung HwaKim, BogyouCai, LingChoi, Hee JuneOhgi, Kenneth ATran, ChrisChen, CharlieChung, Chin HaHuber, OtmarRose, David WSawyers, Charles LRosenfeld, Michael GBaek, Sung HeeNature 434:921-6inferred by electronic annotationIEAGOIEA