BioPAX pathway converted from "Beta-catenin binds SOX proteins" in the Reactome database.Beta-catenin binds SOX proteinsBeta-catenin binds SOX proteinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 103271201nucleoplasmGO0005654UniProt:Q28GC2ctnnb1Reactomehttp://www.reactome.orgXenopus tropicalisNCBI Taxonomy8364UniProtQ28GC2Chain Coordinates1EQUAL781EQUALConverted from EntitySet in ReactomeReactome DB_ID: 103801611SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitysox3 [nucleoplasm]sox9 [nucleoplasm]sox7 [nucleoplasm]sox17a [nucleoplasm]sox2 [nucleoplasm]UniProtQ68FA4UniProtQ6F2E7UniProtQ28GD5UniProtQ8AWH3UniProtQ6NVN0Reactome DB_ID: 103801631CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm]CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17Reactome DB_ID: 1032712011EQUAL781EQUALConverted from EntitySet in ReactomeReactome DB_ID: 103801611Reactome Database ID Release 7510380163Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380163ReactomeR-XTR-56269151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5626915.1Reactome Database ID Release 7510380165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380165ReactomeR-XTR-56269381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5626938.1SOX protein family members are the transcription factors that regulate many different development processes and also control homeostasis in adult tissues. SOX proteins can be either transcriptional activators or repressors depending on the cellular context and their associated interacting proteins (Kormish et al. 2010). There are over twenty SOX proteins encoded in mammalian genome of which many of these can physically interact with beta-catenin and TCF (T-cell factor) transcription factors and modulate the Wnt signaling. Evidences suggest that SOX proteins have widespread role in modulating Wnt signaling in development and disease. In most cases SOX proteins repress WNT transcriptional responses, however some SOX proteins appear to enhance WNT-regulated gene expression. The precise mechanism by which SOX proteins regulate beta-catenin/TCF activity are still unclear. Differential recruitment of transcriptional co-activators or co-repressors is one mechanism by which SOX factors can either enhance or repress Wnt-target gene transcription. Another mechanism by which some SOX proteins repress Wnt signaling is by promoting proteosome-mediated beta-catenin degradation (Kormish et al. 2010). <br>Human SRY binds beta-catenin through a N-terminal domain (Bernard et al. 2008), SOX6 interacts via a centrally located leucine zipper (LZ/Q) element (Iguchi et al. 2007), and mammalian SOX7, SOX9 and SOX17 all bind beta-catenin via their C-terminal regions (Zorn et al., 1999; Takash et al., 2001; Akiyama et al., 2004; Sinner et al., 2007, Kormish et al. 2010). SRY and SOX9 function in part by suppressing canonical Wnt signaling by promoting beta-catenin phosphorylation in the nucleus (Topol et al. 2009). SOX9 and SRY are involved in the regulation of mammalian sex determination and mutation in human SRY and SOX9 results in sex reversal, with female development in XY individuals (Bernard et al. 2008). SOX2 binds beta-catenin and promotes cell proliferation by transcriptionally activating the Wnt target Cyclin D1 gene in breast cancer cells (Chen et al., 2008), whereas SOX6 represses Cyclin D1 transcription in pancreatic cells (Iguchi et al., 2007). SOX7 and SOX17 reduce cyclin-D1 expression and repress proliferation by stimulating beta-catenin degradation (Sinner et al. 2007, Zhang et al. 2008, 2009).15132997Pubmed2004Interactions between Sox9 and beta-catenin control chondrocyte differentiationAkiyama, HaruhikoLyons, Jon PMori-Akiyama, YukoYang, XiaohongZhang, RenZhang, ZhaopingDeng, Jian MinTaketo, Makoto MNakamura, TakashiBehringer, Richard RMcCrea, Pierre Dde Crombrugghe, BenoitGenes Dev. 18:1072-8719631281Pubmed2010All purpose Sox: The many roles of Sox proteins in gene expressionWegner, MichaelInt. J. Biochem. Cell Biol. 42:381-9019854293Pubmed2010Acquisition of SOX transcription factor specificity through protein-protein interaction, modulation of Wnt signalling and post-translational modificationBernard, PascalHarley, Vincent RInt. J. Biochem. Cell Biol. 42:400-1017875931Pubmed2007Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cellsSinner, DéboraKordich, Jennifer JSpence, Jason ROpoka, RobertRankin, ScottLin, Suh-Chin JJonatan, DivaZorn, Aaron MWells, James MMol. Cell. Biol. 27:7802-1517698607Pubmed2007Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epitheliumBastide, PaulineDarido, CharbelPannequin, JulieKist, RalfRobine, SylvieMarty-Double, ChristianeBibeau, FrédéricScherer, GerdJoubert, DominiqueHollande, FrédéricBlache, PhilippeJay, PhilippeJ. Cell Biol. 178:635-4819047045Pubmed2009Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleusTopol, LiliaChen, WenSong, HaiDay, Timothy FYang, YingziJ. Biol. Chem. 284:3323-3324291232Pubmed2014?-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cellsYe, XiaoxiaWu, FangWu, ChengshengWang, PengJung, KarenGopal, KeshavMa, YupoLi, LiangLai, RaymondCell. Signal. 26:492-50119655378Pubmed2010Interactions between SOX factors and Wnt/beta-catenin signaling in development and diseaseKormish, Jay DSinner, DéboraZorn, Aaron MDev. Dyn. 239:56-6818413743Pubmed2008Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancerZhang, WGlöckner, Sabine CGuo, MingzhouMachida, Emi OtaWang, David HEaswaran, HariharanVan Neste, LeanderHerman, James GSchuebel, Kornel EWatkins, D NeilAhuja, NitaBaylin, Stephen BCancer Res. 68:2764-7210549281Pubmed1999Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-cateninZorn, Aaron MBarish, G DWilliams, B OLavender, PKlymkowsky, M WVarmus, H EMol. Cell 4:487-9811691915Pubmed2001SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signallingTakash, WCañizares, JBonneaud, NPoulat, FMattei, M GJay, PBerta, PNucleic Acids Res. 29:4274-8319108950Pubmed2009SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cellsZhang, YuHuang, ShuyanDong, WeiLi, LinFeng, YunpengPan, LinaHan, ZhenkunWang, XiuliRen, GuolingSu, DongmeiHuang, BaiquLu, JunCancer Lett. 277:29-3718456656Pubmed2008The molecular mechanism governing the oncogenic potential of SOX2 in breast cancerChen, YupengShi, LeiZhang, LirongLi, RuifangLiang, JingYu, WenhuaSun, LuyangYang, XiaohanWang, YanZhang, YuShang, YongfengJ. Biol. Chem. 283:17969-7818819930Pubmed2008Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cellsGuo, LizhengZhong, DianshengLau, StephenLiu, XiujuDong, Xue-YuanSun, XiaodongYang, Vincent WVertino, Paula MMoreno, Carlos SVarma, VijayDong, Jin-TangZhou, WeiMol. Cancer Res. 6:1421-3018598779Pubmed2008Human SRY inhibits beta-catenin-mediated transcriptionBernard, PascalSim, HelenaKnower, KevinVilain, EricHarley, VincentInt. J. Biochem. Cell Biol. 40:2889-90017412698Pubmed2007SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferationIguchi, HaruhisaUrashima, YasuyoInagaki, YosukeIkeda, YukioOkamura, MasashiTanaka, TUchida, AoiYamamoto, TTKodama, TSakai, JJ. Biol. Chem. 282:19052-6117218525Pubmed2007Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13Melichar, Heather JNarayan, KavithaDer, Sandy DHiraoka, YoshikiGardiol, NoemieJeannet, GregoireHeld, WernerChambers, Cynthia AKang, JoonsooScience 315:230-3inferred by electronic annotationIEAGOIEA