BioPAX pathway converted from "MAPK4,6 translocate to the cytoplasm" in the Reactome database.MAPK4,6 translocate to the cytoplasmMAPK4,6 translocate to the cytoplasmThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 103841711nucleoplasmGO0005654MAPK4,6 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityphospho-mapk6 [nucleoplasm]MAPK4 [nucleoplasm]mapk6 [nucleoplasm]phospho-p-S186 MAPK4 [nucleoplasm]Reactomehttp://www.reactome.orgXenopus tropicalisNCBI Taxonomy8364UniProtF7EB99UniProtF6XC08Converted from EntitySet in ReactomeReactome DB_ID: 103841631cytosolGO0005829MAPK4,6 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitymapk6 [cytosol]MAPK4 [cytosol]phospho-p-S186 MAPK4 [cytosol]phospho-mapk6 [cytosol]Reactome Database ID Release 7510384175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10384175ReactomeR-XTR-56871091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5687109.1Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003). 12915405Pubmed2003Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progressionJulien, CatherineCoulombe, PhilippeMeloche, SylvainJ. Biol. Chem. 278:42615-2416971392Pubmed2006Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4Aberg, EspenPerander, MariaJohansen, BjarneJulien, CatherineMeloche, SylvainKeyse, Stephen MSeternes, Ole-MortenJ. Biol. Chem. 281:35499-510inferred by electronic annotationIEAGOIEAACTIVATIONReactome Database ID Release 7510384176Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10384176Reactome DB_ID: 10320121UniProt:F7EP94acad8UniProtF7EP94Chain Coordinates1EQUAL1071EQUAL