BioPAX pathway converted from "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane" in the Reactome database.3.1.3PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membranePI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 18062241plasma membraneGO00058861-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]1-phosphatidyl-1D-myo-inositol 3,5-bisphosphatePtsIns-3,5-P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate)PtsIns(3,5)P2Reactomehttp://www.reactome.orgChEBI16851Reactome DB_ID: 293561cytosolGO0005829water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 293721hydrogenphosphate [ChEBI:43474]hydrogenphosphate[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUPChEBI43474Reactome DB_ID: 180624011-phosphatidyl-1D-myo-inositol 5-phosphate [ChEBI:16500]1-phosphatidyl-1D-myo-inositol 5-phosphatePI5PChEBI16500PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10394853MTMR6:MTMR9 [cytosol]MTMR6:MTMR9Reactome DB_ID: 103948511UniProt:A4IHQ8MGC145907Xenopus tropicalisNCBI Taxonomy8364UniProtA4IHQ8Chain Coordinates1EQUAL549EQUALReactome DB_ID: 103585841UniProt:F6ZST8aatfUniProtF6ZST81EQUAL621EQUALReactome Database ID Release 7510394853Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10394853ReactomeR-XTR-68092461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6809246.1GO0052629GO molecular functionReactome Database ID Release 7510394856Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10394856Reactome Database ID Release 7510394858Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10394858ReactomeR-XTR-68093201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6809320.1Formation of a complex with MTMR9 results in a 30-fold increase of phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR6 and a modest increase in the catalytic activity of MTMR8 (Zou et al. 2009, Zou et al. 2012). 22647598Pubmed2012Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8Zou, JZhang, ChunfenMarjanovic, JasnaKisseleva, Marina VMajerus, PWWilson, Monita PProc. Natl. Acad. Sci. U.S.A. 109:9539-4419038970Pubmed2009MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosisZou, JChang, Shao-ChunMarjanovic, JasnaMajerus, PWJ. Biol. Chem. 284:2064-71inferred by electronic annotationIEAGOIEA