BioPAX pathway converted from "PP2A-B56 dephosphorylates centromeric cohesin" in the Reactome database. 3.1.3.16 PP2A-B56 dephosphorylates centromeric cohesin PP2A-B56 dephosphorylates centromeric cohesin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29356 1 cytosol GO 0005829 water [ChEBI:15377] water Reactome http://www.reactome.org ChEBI 15377 Reactome DB_ID: 10404196 1 chromosome, centromeric region GO 0000775 p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 10404184 1 UniProt:E7FCL4 wapalb Danio rerio NCBI Taxonomy 7955 UniProt E7FCL4 Chain Coordinates 1 EQUAL 1190 EQUAL Reactome DB_ID: 1638792 2 chromosome GO 0005694 Sister Centromere [chromosome] Sister Centromere Reactome DB_ID: 10404180 2 Microtubule-bound kinetochore [cytosol] Microtubule-bound kinetochore Reactome DB_ID: 10387813 15 Microtubule [cytosol] Microtubule Reactome DB_ID: 10387811 13 Microtubule protofilament [cytosol] Microtubule protofilament Reactome Database ID Release 82 10387813 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10387813 Reactome R-DRE-190599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-190599.1 Reactome DB_ID: 10363745 1 Kinetochore [cytosol] Kinetochore Reactome DB_ID: 10363551 1 UniProt:Q6NV13 UniProt Q6NV13 1 EQUAL 331 EQUAL Reactome DB_ID: 10363547 1 UniProt:E7F2X0 UniProt E7F2X0 1 EQUAL 1438 EQUAL Reactome DB_ID: 10363443 1 UniProt:Q803Q2 ndel1b UniProt Q803Q2 1 EQUAL 345 EQUAL Reactome DB_ID: 10363451 1 UniProt:F1RCC6 sgol1 UniProt F1RCC6 1 EQUAL 561 EQUAL Reactome DB_ID: 10363463 1 UniProt:Q0P426 ska2 UniProt Q0P426 1 EQUAL 121 EQUAL Reactome DB_ID: 10363447 1 UniProt:Q08BV5 zgc:154097 UniProt Q08BV5 2 EQUAL 587 EQUAL Reactome DB_ID: 10363435 1 UniProt:B0S7G2 UniProt B0S7G2 1 EQUAL 725 EQUAL Reactome DB_ID: 10363517 1 PP2A [cytosol] PP2A Converted from EntitySet in Reactome Reactome DB_ID: 10363509 1 PP2A-subunit A [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Converted from EntitySet in Reactome Reactome DB_ID: 10363499 1 PP2A regulatory subunit B56 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Converted from EntitySet in Reactome Reactome DB_ID: 10363515 1 PP2A-catalytic subunit C [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome Database ID Release 82 10363517 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363517 Reactome R-DRE-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-196206.1 Reactome DB_ID: 10363681 1 UniProt:A0A0R4IU39 UniProt A0A0R4IU39 1 EQUAL 499 EQUAL Reactome DB_ID: 10359314 1 Nup107-160 complex [cytosol] Nup107-160 complex Reactome DB_ID: 10359288 1 UniProt:F1QNV4 nup133 UniProt F1QNV4 1 EQUAL 1156 EQUAL Reactome DB_ID: 10359312 1 UniProt:Q6TGU2 seh1l UniProt Q6TGU2 1 EQUAL 360 EQUAL Reactome DB_ID: 10359306 1 UniProt:Q5RFW3 UniProt Q5RFW3 1 EQUAL 380 EQUAL Reactome DB_ID: 10359310 1 UniProt:A0A2R8RKG2 UniProt A0A2R8RKG2 2 EQUAL 322 EQUAL Reactome DB_ID: 10359292 1 UniProt:A0A2R8Q4U1 UniProt A0A2R8Q4U1 1 EQUAL 1436 EQUAL Reactome DB_ID: 10359296 1 UniProt:Q6DBY0 nup85 UniProt Q6DBY0 1 EQUAL 656 EQUAL Reactome DB_ID: 10359298 1 UniProt:E7F981 UniProt E7F981 1 EQUAL 880 EQUAL Reactome DB_ID: 10359284 1 UniProt:Q5RGI2 UniProt Q5RGI2 1 EQUAL 925 EQUAL Reactome DB_ID: 10359302 1 UniProt:J3JS14 UniProt J3JS14 1 EQUAL 326 EQUAL Reactome Database ID Release 82 10359314 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10359314 Reactome R-DRE-377883 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377883.1 Reactome DB_ID: 10363459 1 UniProt:Q6DHG8 ska1 UniProt Q6DHG8 2 EQUAL 255 EQUAL Reactome DB_ID: 10363531 1 UniProt:F1RAK1 UniProt F1RAK1 1 EQUAL 673 EQUAL Reactome DB_ID: 10363381 1 UniProt:D9IWE2 UniProt D9IWE2 1 EQUAL 718 EQUAL Reactome DB_ID: 10357197 1 UniProt:Q6PBT1 zgc:73262 UniProt Q6PBT1 2 EQUAL 84 EQUAL Reactome DB_ID: 10363709 1 UniProt:A0A0R4IP53 UniProt A0A0R4IP53 1 EQUAL 1001 EQUAL Reactome DB_ID: 10363439 1 UniProt:A0A0R4IFA2 UniProt A0A0R4IFA2 1 EQUAL 346 EQUAL Reactome DB_ID: 10363409 1 UniProt:Q6NUY9 mapre1 UniProt Q6NUY9 2 EQUAL 268 EQUAL Reactome DB_ID: 10363397 1 UniProt:F1Q7X5 si:ch211-152h14.2 UniProt F1Q7X5 1 EQUAL 3207 EQUAL Reactome DB_ID: 10363743 1 Dynein complex [cytosol] Dynein complex Converted from EntitySet in Reactome Reactome DB_ID: 10363731 2 DLCs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity dynll2 [cytosol] dnl2 [cytosol] UniProt Q6PBH4 UniProt Q5BL99 Converted from EntitySet in Reactome Reactome DB_ID: 10363741 2 DLIs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity dncli2 [cytosol] DYNC1LI2 [cytosol] UniProt Q1LUM9 UniProt F1RB89 Reactome DB_ID: 10363713 1 DHC dimer [cytosol] DHC dimer Reactome DB_ID: 10363711 2 Ghost homologue of DYNC1H1 [cytosol] Ghost homologue of DYNC1H1 Reactome Database ID Release 82 10363713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363713 Reactome R-DRE-2029144 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2029144.1 Converted from EntitySet in Reactome Reactome DB_ID: 10363723 2 DICs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity dync1i2a [cytosol] DYNC1I1 [cytosol] UniProt E7F6H7 UniProt A0A0G2KK56 Reactome Database ID Release 82 10363743 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363743 Reactome R-DRE-2029145 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2029145.1 Reactome DB_ID: 10363389 1 UniProt:Q803H4 cenpa UniProt Q803H4 1 EQUAL 140 EQUAL Reactome DB_ID: 10363393 1 UniProt:E7F2U4 UniProt E7F2U4 1 EQUAL 2698 EQUAL Reactome DB_ID: 10363401 1 UniProt:F1R253 UniProt F1R253 1 EQUAL 1538 EQUAL Reactome DB_ID: 10363529 1 UniProt:A0A0R4IZT6 ppp1cc UniProt A0A0R4IZT6 2 EQUAL 323 EQUAL Reactome DB_ID: 10359240 1 UniProt:A0A2R8QJ57 si:ch1073-55a19.2 UniProt A0A2R8QJ57 1 EQUAL 3224 EQUAL Reactome DB_ID: 10363535 1 UniProt:A7MD70 spdl1 UniProt A7MD70 1 EQUAL 605 EQUAL Reactome DB_ID: 10363421 1 1 EQUAL 706 EQUAL Reactome DB_ID: 10363405 1 UniProt:Q6NYW6 clasp2 UniProt Q6NYW6 1 EQUAL 1294 EQUAL Reactome DB_ID: 10363539 1 UniProt:A0A0R4IA93 UniProt A0A0R4IA93 1 EQUAL 2032 EQUAL Reactome DB_ID: 10363611 1 CCAN network [cytosol] CCAN network Reactome DB_ID: 10363559 1 UniProt:Q6DRD4 cenpl UniProt Q6DRD4 1 EQUAL 344 EQUAL Reactome DB_ID: 10363609 1 CENP-(H,I, K) complex [cytosol] CENP-(H,I, K) complex Reactome DB_ID: 10363603 1 UniProt:F1QJK1 UniProt F1QJK1 1 EQUAL 756 EQUAL Reactome DB_ID: 10363607 1 UniProt:B8JK99 si:dkey-179o14.3 UniProt B8JK99 1 EQUAL 269 EQUAL Reactome DB_ID: 10363599 1 UniProt:A8WHV8 si:dkey-186m8.3 UniProt A8WHV8 1 EQUAL 247 EQUAL Reactome Database ID Release 82 10363609 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363609 Reactome R-DRE-377884 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377884.1 Reactome DB_ID: 10363563 1 UniProt:Q7ZZC6 cenpm UniProt Q7ZZC6 1 EQUAL 180 EQUAL Reactome DB_ID: 10363567 1 UniProt:Q6DHP4 si:busm1-241h12.3 UniProt Q6DHP4 1 EQUAL 339 EQUAL Reactome DB_ID: 10363555 1 UniProt:E7FAC3 UniProt E7FAC3 1 EQUAL 943 EQUAL Reactome DB_ID: 10363571 1 UniProt:B3DJV8 apitd1 UniProt B3DJV8 1 EQUAL 138 EQUAL Reactome DB_ID: 10363575 1 UniProt:E9QIT3 si:ch211-225g23.1 UniProt E9QIT3 1 EQUAL 561 EQUAL Reactome DB_ID: 10363595 1 CENP-O complex [cytosol] CENP-O complex Reactome DB_ID: 10363583 1 UniProt:Q1LV50 cenpp UniProt Q1LV50 1 EQUAL 288 EQUAL Reactome DB_ID: 10363585 1 Ghost homologue of CENPQ [cytosol] Ghost homologue of CENPQ Reactome DB_ID: 10363593 1 UniProt:X1WGM0 si:dkey-148h10.5 UniProt X1WGM0 1 EQUAL 177 EQUAL Reactome DB_ID: 10363579 1 UniProt:X1WGY1 UniProt X1WGY1 1 EQUAL 300 EQUAL Reactome DB_ID: 10363589 1 UniProt:E7FCV0 UniProt E7FCV0 1 EQUAL 418 EQUAL Reactome Database ID Release 82 10363595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363595 Reactome R-DRE-377886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377886.1 Reactome Database ID Release 82 10363611 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363611 Reactome R-DRE-377738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377738.1 Reactome DB_ID: 10363705 1 UniProt:A2BGR3 UniProt A2BGR3 1 EQUAL 1250 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10363431 1 Homologues of PAFAH1B1 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity pafah1b1b [cytosol] pafah1b1a [cytosol] UniProt Q803D2 UniProt Q7T394 Reactome DB_ID: 10363653 1 KMN network [cytosol] KMN network Reactome DB_ID: 10363633 1 Mis12 complex [cytosol] Mis12 complex Reactome DB_ID: 10363627 1 UniProt:Q5RGS8 si:ch211-147d7.3 UniProt Q5RGS8 1 EQUAL 281 EQUAL Reactome DB_ID: 10363631 1 UniProt:F1Q903 UniProt F1Q903 2 EQUAL 205 EQUAL Reactome DB_ID: 10363619 1 UniProt:E7FD92 UniProt E7FD92 1 EQUAL 356 EQUAL Reactome DB_ID: 10363623 1 UniProt:F1QY72 UniProt F1QY72 1 EQUAL 205 EQUAL Reactome Database ID Release 82 10363633 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363633 Reactome R-DRE-375441 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-375441.1 Reactome DB_ID: 10363615 1 UniProt:F1R5N3 si:dkey-9k8.1 UniProt F1R5N3 1 EQUAL 2342 EQUAL Reactome DB_ID: 10363651 1 NDC80 complex [cytosol] NDC80 complex Reactome DB_ID: 10363645 1 UniProt:Q503N2 spc24 UniProt Q503N2 1 EQUAL 197 EQUAL Reactome DB_ID: 10363641 1 UniProt:Q7ZW63 nuf2 UniProt Q7ZW63 1 EQUAL 464 EQUAL Reactome DB_ID: 10363649 1 UniProt:B0UYS8 zgc:171542 UniProt B0UYS8 1 EQUAL 224 EQUAL Reactome DB_ID: 10363637 1 UniProt:Q6DRJ7 ndc80 UniProt Q6DRJ7 1 EQUAL 642 EQUAL Reactome Database ID Release 82 10363651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363651 Reactome R-DRE-375444 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-375444.1 Reactome Database ID Release 82 10363653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363653 Reactome R-DRE-377745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377745.1 Reactome DB_ID: 10363525 1 UniProt:Q6DRK7 UniProt Q6DRK7 1 EQUAL 603 EQUAL Reactome DB_ID: 10363697 1 RZZ complex [cytosol] RZZ complex Reactome DB_ID: 10363687 1 UniProt:A0A0R4IHW6 UniProt A0A0R4IHW6 1 EQUAL 2209 EQUAL Reactome DB_ID: 10363691 1 UniProt:A5WWB6 zwilch UniProt A5WWB6 1 EQUAL 591 EQUAL Reactome DB_ID: 10363695 1 UniProt:F1QYH5 UniProt F1QYH5 2 EQUAL 779 EQUAL Reactome Database ID Release 82 10363697 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363697 Reactome R-DRE-377885 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377885.1 Reactome DB_ID: 10363417 1 UniProt:B0V302 UniProt B0V302 1 EQUAL 898 EQUAL Reactome DB_ID: 10363665 1 Chromosome passenger complex [cytosol] Chromosome passenger complex Reactome DB_ID: 10363657 1 UniProt:Q6NW76 UniProt Q6NW76 1 EQUAL 344 EQUAL Reactome DB_ID: 10363659 1 Ghost homologue of BIRC5 [cytosol] Ghost homologue of BIRC5 Reactome DB_ID: 10363663 1 UniProt:Q5XLR4 cdca8 UniProt Q5XLR4 1 EQUAL 280 EQUAL Reactome DB_ID: 10363385 1 UniProt:A0A0G2L1R2 incenp UniProt A0A0G2L1R2 1 EQUAL 918 EQUAL Reactome Database ID Release 82 10363665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363665 Reactome R-DRE-377879 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377879.1 Reactome DB_ID: 10363683 1 Mitotic checkpoint complex [cytosol] Mitotic checkpoint complex Reactome DB_ID: 10363673 1 UniProt:F1Q636 si:ch211-158b22.2 UniProt F1Q636 1 EQUAL 1050 EQUAL Reactome DB_ID: 10363677 1 UniProt:U3JAH9 UniProt U3JAH9 1 EQUAL 328 EQUAL Reactome DB_ID: 10363669 1 UniProt:F1QHN1 UniProt F1QHN1 2 EQUAL 205 EQUAL Reactome DB_ID: 10363681 1 1 EQUAL 499 EQUAL Reactome Database ID Release 82 10363683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363683 Reactome R-DRE-377882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-377882.1 Reactome DB_ID: 10363701 1 UniProt:F1QNS6 si:ch1073-192f24.1 UniProt F1QNS6 1 EQUAL 1085 EQUAL Reactome DB_ID: 10363471 1 UniProt:A0A0G2L5W1 UniProt A0A0G2L5W1 1 EQUAL 277 EQUAL Reactome DB_ID: 10363543 1 UniProt:Q6DGZ1 b9d2 UniProt Q6DGZ1 1 EQUAL 175 EQUAL Reactome DB_ID: 10363455 1 UniProt:B0UYN0 si:dkey-57a22.11 UniProt B0UYN0 1 EQUAL 1265 EQUAL Reactome DB_ID: 10363413 1 UniProt:X1WE68 UniProt X1WE68 1 EQUAL 2266 EQUAL Reactome DB_ID: 10363521 1 UniProt:A0A2R8RNP8 UniProt A0A2R8RNP8 1 EQUAL 1071 EQUAL Reactome DB_ID: 10363467 1 UniProt:Q6NYE2 rcc2 UniProt Q6NYE2 1 EQUAL 522 EQUAL Reactome DB_ID: 10363385 1 1 EQUAL 918 EQUAL Reactome Database ID Release 82 10363745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10363745 Reactome R-DRE-375305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-375305.1 Reactome Database ID Release 82 10404180 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404180 Reactome R-DRE-375303 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-375303.1 Converted from EntitySet in Reactome Reactome DB_ID: 10404171 1 PDS5 [chromosome, centromeric region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity pds5a [chromosome, centromeric region] PDS5B [chromosome, centromeric region] UniProt A1L1F4 UniProt A0A0R4IP12 Reactome DB_ID: 10404194 1 p-STAG2,RAD21-Ac-Cohesin [chromosome, centromeric region] p-STAG2,RAD21-Ac-Cohesin Reactome DB_ID: 10404189 1 UniProt:A0A0R4IZR5 UniProt A0A0R4IZR5 phosphorylated residue at unknown position phosphorylated residue [MOD:00696] 1 EQUAL 1231 EQUAL Reactome DB_ID: 10404192 1 UniProt:Q1L8E1 si:ch211-246f9.1 UniProt Q1L8E1 O-phospho-L-serine at 454 (in Homo sapiens) 454 EQUAL O-phospho-L-serine [MOD:00046] 1 EQUAL 631 EQUAL Reactome DB_ID: 10404145 1 UniProt:B0V0X2 UniProt B0V0X2 1 EQUAL 1258 EQUAL Reactome DB_ID: 10404159 1 UniProt:Q1LVV8 UniProt Q1LVV8 N6-acetyl-L-lysine at 105 (in Homo sapiens) 105 EQUAL N6-acetyl-L-lysine [MOD:00064] N6-acetyl-L-lysine at 106 (in Homo sapiens) 106 EQUAL 1 EQUAL 1217 EQUAL Reactome DB_ID: 10404153 1 UniProt:E7F0X6 UniProt E7F0X6 1 EQUAL 1233 EQUAL Reactome Database ID Release 82 10404194 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404194 Reactome R-DRE-2484809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2484809.1 Reactome DB_ID: 10404178 1 UniProt:A2BIB1 si:dkey-273o13.2 UniProt A2BIB1 O-phospho-L-threonine at 159 (in Homo sapiens) 159 EQUAL O-phospho-L-threonine [MOD:00047] O-phospho-L-serine at 21 (in Homo sapiens) 21 EQUAL O-phospho-L-serine at 75 (in Homo sapiens) 75 EQUAL 1 EQUAL 252 EQUAL Reactome Database ID Release 82 10404196 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404196 Reactome R-DRE-1638796 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1638796.1 Reactome DB_ID: 10404203 1 p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 10404184 1 1 EQUAL 1190 EQUAL Reactome DB_ID: 10404201 1 p-RAD21-Ac-Cohesin [chromosome, centromeric region] p-RAD21-Ac-Cohesin Reactome DB_ID: 10404192 1 O-phospho-L-serine at 454 (in Homo sapiens) 454 EQUAL 1 EQUAL 631 EQUAL Reactome DB_ID: 10404149 1 1 EQUAL 1231 EQUAL Reactome DB_ID: 10404145 1 1 EQUAL 1258 EQUAL Reactome DB_ID: 10404159 1 N6-acetyl-L-lysine at 105 (in Homo sapiens) 105 EQUAL N6-acetyl-L-lysine at 106 (in Homo sapiens) 106 EQUAL 1 EQUAL 1217 EQUAL Reactome DB_ID: 10404153 1 1 EQUAL 1233 EQUAL Reactome Database ID Release 82 10404201 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404201 Reactome R-DRE-2500251 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2500251.1 Reactome DB_ID: 1638792 2 Reactome DB_ID: 10404180 2 Converted from EntitySet in Reactome Reactome DB_ID: 10404171 1 Reactome DB_ID: 10404178 1 O-phospho-L-threonine at 159 (in Homo sapiens) 159 EQUAL O-phospho-L-serine at 21 (in Homo sapiens) 21 EQUAL O-phospho-L-serine at 75 (in Homo sapiens) 75 EQUAL 1 EQUAL 252 EQUAL Reactome Database ID Release 82 10404203 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404203 Reactome R-DRE-2500242 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2500242.1 Reactome DB_ID: 29372 1 hydrogenphosphate [ChEBI:43474] hydrogenphosphate [PO3(OH)](2-) HYDROGENPHOSPHATE ION hydrogen phosphate [P(OH)O3](2-) HPO4(2-) phosphate INORGANIC PHOSPHATE GROUP ChEBI 43474 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10404196 GO 0004722 GO molecular function Reactome Database ID Release 82 10404204 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404204 Reactome Database ID Release 82 10404206 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10404206 Reactome R-DRE-1638821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-1638821.1 PLK1-mediated phosphorylation of the STAG2 subunit of centromeric cohesin (Hauf et al. 2005) is counteracted by the kinetochore PP2A phosphatase, containing the 56 kDa regulatory B subunit (PP2A-B56 i.e. PP2A-PPP2R5). PP2A-B56 is recruited to the centromeric cohesin complex by shugoshin proteins (SGOL1 and SGOL2) (Kitajima et al. 2006), which are also kinetochore constituents (Cheeseman and Desai 2008). SGOL1 localization to centromeres is sustained by the interaction with histone H2A possessing the phosphorylation of T120 which is introduced by the protein kinase BUB1, and heterochromatin protein HP1 (Kitajima et al. 2005, Kawashima et al. 2010, Yamagishi et al. 2008). Shugoshin- and PP2A-B56-regulated dephosphorylation of centromeric STAG2 ensures that the cohesin complex remains bound to centromeres throughout prometaphase and metaphase, thereby preventing premature separation of sister chromatids (Salic et al. 2004, Kitajima et al. 2004, Kitajima et al. 2005, Kitajima et al. 2006). 19965387 Pubmed 2010 Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin Kawashima, Shigehiro A Yamagishi, Yuya Honda, Takashi Ishiguro, K Watanabe, Yoshinori Science 327:172-7 14730319 Pubmed 2004 The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis Kitajima, Tomoya S Kawashima, Shigehiro A Watanabe, Yoshinori Nature 427:510-7 18716626 Pubmed 2008 Heterochromatin links to centromeric protection by recruiting shugoshin Yamagishi, Yuya Sakuno, T Shimura, Mari Watanabe, Yoshinori Nature 455:251-5 16541025 Pubmed 2006 Shugoshin collaborates with protein phosphatase 2A to protect cohesin Kitajima, TS Sakuno, T Ishiguro, K Iemura, S Natsume, T Kawashima, SA Watanabe, Yoshinori Nature 441:46-52 15737063 Pubmed 2005 Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 Hauf, S Roitinger, E Koch, B Dittrich, CM Mechtler, K Peters, JM PLoS Biol 3:e69 15339662 Pubmed 2004 Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis Salic, Adrian Waters, Jennifer C Mitchison, Timothy J Cell 118:567-78 18097444 Pubmed 2008 Molecular architecture of the kinetochore-microtubule interface Cheeseman, IM Desai, A Nat Rev Mol Cell Biol 9:33-46 15723797 Pubmed 2005 Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization Kitajima, Tomoya S Hauf, Silke Ohsugi, Miho Yamamoto, Tadashi Watanabe, Yoshinori Curr. Biol. 15:353-9 inferred by electronic annotation IEA GO IEA