BioPAX pathway converted from "NEDD8 and UBD bind NUB1 and the 26S proteasome" in the Reactome database.NEDD8 and UBD bind NUB1 and the 26S proteasomeNEDD8 and UBD bind NUB1 and the 26S proteasomeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 103068821cytosolGO000582926S proteasome [cytosol]26S proteasomeReactome DB_ID: 103067141UniProt:Q5BJ72psmd14Reactomehttp://www.reactome.orgXenopus tropicalisNCBI Taxonomy8364UniProtQ5BJ72Chain Coordinates1EQUAL310EQUALReactome DB_ID: 103067641UniProt:F6WGD3psmb5UniProtF6WGD360EQUAL263EQUALReactome DB_ID: 103068741Ghost homologue of PSMA8 [cytosol]Ghost homologue of PSMA8Reactome DB_ID: 103068261UniProt:F7CS21psmd2UniProtF7CS211EQUAL908EQUALReactome DB_ID: 103067781UniProt:F6ZK13UniProtF6ZK1321EQUAL219EQUALReactome DB_ID: 103068341UniProt:F6YUT8UniProtF6YUT81EQUAL377EQUALReactome DB_ID: 103068381UniProt:B1H2W9psmd5UniProtB1H2W92EQUAL504EQUALReactome DB_ID: 103067581UniProt:F7DUU5panx2UniProtF7DUU52EQUAL205EQUALReactome DB_ID: 103068021UniProt:F6WV97psmc6UniProtF6WV971EQUAL389EQUALReactome DB_ID: 103067221UniProt:F6YDY3UniProtF6YDY32EQUAL234EQUALReactome DB_ID: 103067421UniProt:F6PMD9UniProtF6PMD91EQUAL248EQUALReactome DB_ID: 103067941UniProt:Q66JJ6psmc4UniProtQ66JJ61EQUAL418EQUALReactome DB_ID: 103068301UniProt:F6YQ90psmd3UniProtF6YQ901EQUAL534EQUALReactome DB_ID: 103068721UniProt:F7A0A4dmgdhUniProtF7A0A41EQUAL1843EQUALReactome DB_ID: 103068621UniProt:F6Y882UniProtF6Y8822EQUAL239EQUALReactome DB_ID: 103068541UniProt:F7AA85psmd9UniProtF7AA851EQUAL223EQUALReactome DB_ID: 103067821UniProt:F6ZPI8UniProtF6ZPI82EQUAL440EQUALReactome DB_ID: 103068061UniProt:F6WGT0btrcUniProtF6WGT01EQUAL953EQUALReactome DB_ID: 103067461UniProt:F7EGM2UniProtF7EGM229EQUAL241EQUALReactome DB_ID: 103067341UniProt:F6QN60psma5UniProtF6QN601EQUAL241EQUALReactome DB_ID: 103067381UniProt:Q6P7Z3psma6UniProtQ6P7Z31EQUAL246EQUALReactome DB_ID: 103067741UniProt:F7A543slc7a8UniProtF7A54373EQUAL276EQUALReactome DB_ID: 103068141UniProt:V9GZ90UniProtV9GZ902EQUAL422EQUALReactome DB_ID: 103067701UniProt:F7EHN5dach1UniProtF7EHN544EQUAL277EQUALReactome DB_ID: 103068461UniProt:Q5M8I9psmd7UniProtQ5M8I91EQUAL324EQUALReactome DB_ID: 103068781UniProt:F7EDI0UniProtF7EDI050EQUAL300EQUALReactome DB_ID: 103068581UniProt:F6RBQ3UniProtF6RBQ31EQUAL249EQUALReactome DB_ID: 103068681Ghost homologue of PSMF1 [cytosol]Ghost homologue of PSMF1Reactome DB_ID: 103067861UniProt:F7A7D6psmc2UniProtF7A7D62EQUAL433EQUALReactome DB_ID: 103067541UniProt:F7A058psmb2UniProtF7A0581EQUAL201EQUALReactome DB_ID: 103067661Ghost homologue of PSMB6 [cytosol]Ghost homologue of PSMB6Reactome DB_ID: 103067501UniProt:F7B3J1psmb7.2UniProtF7B3J140EQUAL273EQUALReactome DB_ID: 103068801Ghost homologue of SHFM1 [cytosol]Ghost homologue of SHFM1Reactome DB_ID: 103067181UniProt:F6VFT5UniProtF6VFT51EQUAL263EQUALReactome DB_ID: 103067601Ghost homologue of PSMB4 [cytosol]Ghost homologue of PSMB4Reactome DB_ID: 103068181UniProt:F6WT39UniProtF6WT392EQUAL456EQUALReactome DB_ID: 103068421UniProt:Q6P2Y7psmd6UniProtQ6P2Y71EQUAL389EQUALReactome DB_ID: 103067261UniProt:F6XZS3smarcd3UniProtF6XZS32EQUAL255EQUALReactome DB_ID: 103068661UniProt:F6V8H8psme3UniProtF6V8H82EQUAL254EQUALReactome DB_ID: 103067301UniProt:F7CDN5psma4UniProtF7CDN51EQUAL261EQUALReactome DB_ID: 103068101UniProt:F6W937psmd10UniProtF6W9371EQUAL226EQUALReactome DB_ID: 103068221UniProt:F6VLC5psmd13UniProtF6VLC51EQUAL376EQUALReactome DB_ID: 103068501UniProt:F7E8M8psmd8UniProtF7E8M81EQUAL350EQUALReactome DB_ID: 103067901UniProt:F6V1I7psmc3UniProtF6V1I71EQUAL439EQUALReactome DB_ID: 103067981UniProt:F6XF46kif23UniProtF6XF462EQUAL406EQUALReactome Database ID Release 7510306882Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306882ReactomeR-XTR-688191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68819.1Reactome DB_ID: 104053831UniProt:F6WED2nub1UniProtF6WED21EQUAL615EQUALReactome DB_ID: 103855871UniProt:Q28E73nedd8UniProtQ28E731EQUAL76EQUALReactome DB_ID: 104053851NEDD8,UBD:NUB1:26S proteasome [cytosol]NEDD8,UBD:NUB1:26S proteasomeReactome DB_ID: 103068821Reactome DB_ID: 1040538311EQUAL615EQUALReactome DB_ID: 1038558711EQUAL76EQUALReactome Database ID Release 7510405385Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405385ReactomeR-XTR-89561371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8956137.1Reactome Database ID Release 7510405387Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10405387ReactomeR-XTR-89561401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-8956140.1NEDD8 ultimate buster 1 (NUB1) is a negative regulator of the NEDD8 conjugation system. NUB1 interacts with NEDD8 and another ubiquitin-like modifier, UBD (also known as FAT10) to promote their degradation and that of their conjugated proteins (Kito et al, 2001; Kamitani et al, 2001; Hipp et al, 2004; Schmidtke et al, 2006). NUB1 interacts directly with both NEDD8/UBD and with PMSD4, a subunit of the 19S cap of the 26S proteasome, through a ubiquitin-like domain (UBL), and in this way promotes the contact between the proteasome and its substrate (Kito et al, 2001; Kamitani et al, 2001; Hipp et al, 2004; Tanji et al, 2005; Schmidtke et al, 2006; reviewed in Tanaka et al, 2012; Schmidtke et al, 2014). There are two isoforms of NUB1 in human cells that differ by the presence of a 14 amino acid insertion in the NUB1L. NUB1L promotes the degradation of NEDD8 more efficiently than the short isoform (Tanaka et al, 2003).11585840Pubmed2001Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1Kamitani, TetsuKito, KatsumiFukuda-Kamitani, TaekoYeh, Edward TJ. Biol. Chem. 276:46655-6014757770Pubmed2004NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradationHipp, Mark SteffenRaasi, ShahriGroettrup, MarcusSchmidtke, GunterJ. Biol. Chem. 279:16503-1012816948Pubmed2003Regulation of the NEDD8 conjugation system by a splicing variant, NUB1LTanaka, TomoakiKawashima, HidenoriYeh, Edward T HKamitani, TetsuJ. Biol. Chem. 278:32905-1323333871Pubmed2014FAT10ylation as a signal for proteasomal degradationSchmidtke, GunterAichem, AnnetteGroettrup, MarcusBiochim. Biophys. Acta 1843:97-10211259415Pubmed2001NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expressionKito, KatsumiYeh, Edward TKamitani, TetsuJ. Biol. Chem. 276:20603-916171779Pubmed2005Interaction of NUB1 with the proteasome subunit S5aTanji, KunikazuTanaka, TomoakiKamitani, TetsuBiochem. Biophys. Res. Commun. 337:116-2022306028Pubmed2012Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyTanaka, TomoakiNakatani, TatsuyaKamitani, TetsuMol Oncol 6:267-7516707496Pubmed2006The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10Schmidtke, GunterKalveram, BirteWeber, ElviraBochtler, PetraLukasiak, SebastianHipp, Mark SteffenGroettrup, MarcusJ. Biol. Chem. 281:20045-54inferred by electronic annotationIEAGOIEA