BioPAX pathway converted from "DNA replication initiation" in the Reactome database.DNA replication initiationDNA replication initiationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>2.7.7.6The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the originThe primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 305951nucleoplasmGO0005654NTP [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGTP [nucleoplasm]CTP [nucleoplasm]UTP [nucleoplasm]ATP [nucleoplasm]Reactomehttp://www.reactome.orgChEBI15996ChEBI17677ChEBI15713ChEBI30616Reactome DB_ID: 103069611DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm]DNA polymerase alpha:primase:DNA polymerase alpha:origin complexReactome DB_ID: 103069591DNA polymerase epsilon:origin complex [nucleoplasm]DNA polymerase epsilon:origin complexReactome DB_ID: 103069571DNA polymerase epsilon [nucleoplasm]DNA polymerase epsilonReactome DB_ID: 103069451UniProt:F6VH50lifrXenopus tropicalisNCBI Taxonomy8364UniProtF6VH50Chain Coordinates1EQUAL2286EQUALReactome DB_ID: 103069511Ghost homologue of POLE3 [nucleoplasm]Ghost homologue of POLE3Reactome DB_ID: 103069551UniProt:B1WB35UniProtB1WB352EQUAL117EQUALReactome DB_ID: 103069491UniProt:F7DWR9pglyrp1UniProtF7DWR91EQUAL527EQUALReactome Database ID Release 7510306957Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306957ReactomeR-XTR-684831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68483.1Reactome DB_ID: 684191origin of replication [nucleoplasm]origin of replicationARSautonomously replicating sequenceoriginReactome Database ID Release 7510306959Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306959ReactomeR-XTR-684851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68485.1Reactome DB_ID: 103069411DNA polymerase alpha:primase [nucleoplasm]DNA polymerase alpha:primaseReactome DB_ID: 103069251UniProt:F6Z608itgb3UniProtF6Z6081EQUAL1462EQUALReactome DB_ID: 103069391PRIM1:PRIM2 [nucleoplasm]PRIM1:PRIM2Reactome DB_ID: 103069371UniProt:F7E6D2prim2UniProtF7E6D21EQUAL509EQUALReactome DB_ID: 103069331UniProt:F6RLA0prim1UniProtF6RLA01EQUAL420EQUALReactome Database ID Release 7510306939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306939ReactomeR-XTR-96688121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9668812.1Reactome DB_ID: 103069291UniProt:Q6DEY9pola2UniProtQ6DEY91EQUAL598EQUALReactome Database ID Release 7510306941Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306941ReactomeR-XTR-685071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68507.1Reactome Database ID Release 7510306961Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306961ReactomeR-XTR-685101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68510.1Reactome DB_ID: 103069631RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm]RNA primer:origin duplex:DNA polymerase alpha:primase complexReactome DB_ID: 684221RNA primer [nucleoplasm]RNA primerReactome DB_ID: 103069411Reactome DB_ID: 684191Reactome Database ID Release 7510306963Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306963ReactomeR-XTR-684231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68423.1Reactome DB_ID: 103069571PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10306961GO0003899GO molecular functionReactome Database ID Release 7510306964Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306964Reactome Database ID Release 7510306966Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10306966ReactomeR-XTR-689131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68913.1At the beginning of this reaction, 1 molecule of 'DNA polymerase alpha:primase:DNA polymerase alpha:origin complex', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex' are present.<br><br> This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'DNA polymerase alpha:primase'.<br>6693436Pubmed1984DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.Wang, TSHu, SZKorn, DJ Biol Chem 259:1854-65inferred by electronic annotationIEAGOIEA2.7.7.7The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the originThe polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 296041dATP [ChEBI:16284]dATP2'-deoxyadenosine 5'-triphosphateDeoxyadenosine triphosphateDeoxyadenosine 5'-triphosphateChEBI16284Reactome DB_ID: 301851dCTP [ChEBI:16311]dCTP2'-Deoxycytidine 5'-triphosphateDeoxycytidine triphosphatedeoxycytidine 5'-triphosphateChEBI16311Reactome DB_ID: 298921dGTP [ChEBI:16497]dGTPDeoxyguanosine 5'-triphosphate2'-deoxyguanosine 5'-triphosphateDeoxyguanosine triphosphateChEBI16497Reactome DB_ID: 301871dTTP [ChEBI:18077]dTTPDeoxythymidine triphosphateTTPDeoxythymidine 5'-triphosphateChEBI18077Reactome DB_ID: 103069631Reactome DB_ID: 103071151RNA primer-DNA primer:origin duplex [nucleoplasm]RNA primer-DNA primer:origin duplexReactome DB_ID: 103069631Reactome DB_ID: 684241DNA primer [nucleoplasm]DNA primerReactome Database ID Release 7510307115Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307115ReactomeR-XTR-684251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68425.1PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10306941GO0003887GO molecular functionReactome Database ID Release 7510307116Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307116Reactome Database ID Release 7510307118Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10307118ReactomeR-XTR-689501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68950.1At the beginning of this reaction, 1 molecule of 'dTTP', 1 molecule of 'dGTP', 1 molecule of 'dATP', 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex', and 1 molecule of 'dCTP' are present. At the end of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present.<br><br> This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase alpha:primase'.<br>6094569Pubmed1984Purification of a DNA polymerase-DNA primase complex from calf thymus glandsChang, L MRafter, EAugl, CBollum, F JJ. Biol. Chem. 259:14679-87inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510409406Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409406ReactomeR-XTR-689521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68952.1GO0006270GO biological processDNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984).11395402Pubmed2002DNA primases.Frick, DNRichardson, CCAnnu Rev Biochem 70:39-80inferred by electronic annotationIEAGOIEA