BioPAX pathway converted from "SOS-mediated signalling" in the Reactome database.SOS-mediated signallingSOS-mediated signallingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GRB2-1:SOS1 binds p-IRS1,p-IRS2GRB2-1:SOS1 binds p-IRS1,p-IRS2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 103115701cytosolGO0005829p-Y-IRS1,p-Y-IRS2 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityphospho-p-Y-IRS1 [cytosol]phospho-p-Y-IRS2 [cytosol]Reactomehttp://www.reactome.orgXenopus tropicalisNCBI Taxonomy8364UniProtF6ZZ77UniProtF6TDY1Reactome DB_ID: 103117431GRB2-1:SOS1 [cytosol]GRB2-1:SOS1Reactome DB_ID: 103117371UniProt:Q66II3grb2UniProtQ66II3Chain Coordinates1EQUAL217EQUALReactome DB_ID: 103117411UniProt:F7EBQ3cyp39a1UniProtF7EBQ31EQUAL1333EQUALReactome Database ID Release 7510311743Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10311743ReactomeR-XTR-1097971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109797.1Reactome DB_ID: 103117451GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2Converted from EntitySet in ReactomeReactome DB_ID: 103115701Reactome DB_ID: 103117431Reactome Database ID Release 7510311745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10311745ReactomeR-XTR-1098001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109800.1Reactome Database ID Release 7510311747Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10311747ReactomeR-XTR-747361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-74736.1Inactive p21ras:GDP is anchored to the plasma membrane by a farnesyl residue. Insulin stimulation results in phosphorylation of IRS1/2 on tyrosine residues. GRB2 binds the phosphotyrosines via its SH2 domain. As IRS is phosphorylated by the insulin receptor near to the plasma membrane, the GRB2:SOS1:IRS interaction brings SOS1 and p21 Ras into close proximity.9852124Pubmed1998Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signalingKim, BCheng, H LMargolis, BFeldman, E LJ. Biol. Chem. 273:34543-508316835Pubmed1993The function of GRB2 in linking the insulin receptor to Ras signaling pathways.Skolnik, EYBatzer, ALi, NLee, CHLowenstein, EMohammadi, MMargolis, BSchlessinger, JScience 260:1953-59832424Pubmed1998Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cellsKim, BLeventhal, P SWhite, MFFeldman, E LEndocrinology 139:4881-98530377Pubmed1995Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domainsXu, BBird, V GMiller, W TJ. Biol. Chem. 270:29825-308810325Pubmed1996Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.Okada, SPessin, JEJ Biol Chem 271:25533-89003010Pubmed1997Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblastsTakahashi, YTobe, KKadowaki, HKatsumata, DFukushima, YYazaki, YAkanuma, YKadowaki, TEndocrinology 138:741-508621421Pubmed1996Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factorWard, C WGough, K HRashke, MWan, S STribbick, GWang, JJ. Biol. Chem. 271:5603-9inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510409724Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409724ReactomeR-XTR-1124121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-112412.1SOS is recruited to the plasma membrane and mediates activation of Ras.inferred by electronic annotationIEAGOIEA