BioPAX pathway converted from "Phosphorylation of WWTR1 (TAZ) by LATS2" in the Reactome database. 2.7.11.1 Phosphorylation of WWTR1 (TAZ) by LATS2 Phosphorylation of WWTR1 (TAZ) by LATS2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 113592 1 cytosol GO 0005829 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 10410010 1 UniProt:Q307I6 Danio rerio NCBI Taxonomy 7955 UniProt Q307I6 Chain Coordinates 1 EQUAL 400 EQUAL Reactome DB_ID: 29370 1 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 Reactome DB_ID: 10410004 1 O-phospho-L-serine at 89 (in Homo sapiens) 89 EQUAL O-phospho-L-serine [MOD:00046] 1 EQUAL 400 EQUAL PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10409924 p-LATS2:p-MOB1 [cytosol] p-LATS2:p-MOB1 Reactome DB_ID: 10409915 1 UniProt:A0A2R8QF71 UniProt A0A2R8QF71 O-phospho-L-serine at 871 (in Homo sapiens) 871 EQUAL O-phospho-L-threonine at 1041 (in Homo sapiens) 1041 EQUAL O-phospho-L-threonine [MOD:00047] 1 EQUAL 1088 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10409905 1 p-MOB1 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phospho-zgc:77872 [cytosol] phospho-p-T12,T35-MOB1A [cytosol] UniProt Q7ZV94 UniProt A0A2R8Q1Z8 Reactome Database ID Release 82 10409924 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409924 Reactome R-DRE-2028584 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028584.1 GO 0004674 GO molecular function Reactome Database ID Release 82 10409925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409925 Reactome Database ID Release 82 10410012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410012 Reactome R-DRE-2028661 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028661.1 Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89 (Lei et al. 2008). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Zhao et al. 2011). 21205866 Pubmed 2011 Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein Zhao, B Li, L Lu, Q Wang, LH Liu, CY Lei, Q Guan, KL Genes Dev 25:51-63 18227151 Pubmed 2008 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway Lei, Q Zhang, H Zhao, B Zha, ZY Bai, F Pei, XH Zhao, S Xiong, Y Guan, KL Mol Cell Biol 28:2426-36 inferred by electronic annotation IEA GO IEA ACTIVATION Reactome Database ID Release 82 10409942 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409942 Converted from EntitySet in Reactome Reactome DB_ID: 10409939 AMOT proteins [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity AMOT-1 [cytosol] amotl1 [cytosol] amotl2a [cytosol] UniProt E9QFX4 UniProt E7FCE7 UniProt A1YB07