BioPAX pathway converted from "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" in the Reactome database. 2.7.11.1 Phosphorylation of MOB1A and B by p-STK3(MST2)/N Phosphorylation of MOB1A and B by p-STK3(MST2)/N This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 113592 2 cytosol GO 0005829 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Converted from EntitySet in Reactome Reactome DB_ID: 10409993 1 MOB1 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity MOB1A [cytosol] zgc:77872 [cytosol] Danio rerio NCBI Taxonomy 7955 UniProt A0A2R8Q1Z8 UniProt Q7ZV94 Reactome DB_ID: 29370 2 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 Converted from EntitySet in Reactome Reactome DB_ID: 10409905 1 p-MOB1 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phospho-zgc:77872 [cytosol] phospho-p-T12,T35-MOB1A [cytosol] PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10410018 p-STK3/N:p-SAV1 [cytosol] p-STK3/N:p-SAV1 Reactome DB_ID: 10409949 1 p-SAV1 dimer [cytosol] p-SAV1 dimer Reactome DB_ID: 10409947 2 UniProt:Q66HX5 UniProt Q66HX5 phosphorylated residue at unknown position phosphorylated residue [MOD:00696] Chain Coordinates 1 EQUAL 383 EQUAL Reactome Database ID Release 82 10409949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10409949 Reactome R-DRE-2028281 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028281.1 Reactome DB_ID: 10410016 1 p-STK3/N dimer [cytosol] p-STK3/N dimer Reactome DB_ID: 10410014 2 UniProt:Q7ZUQ3 UniProt Q7ZUQ3 O-phospho-L-threonine at 180 (in Homo sapiens) 180 EQUAL O-phospho-L-threonine [MOD:00047] 1 EQUAL 322 EQUAL Reactome Database ID Release 82 10410016 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410016 Reactome R-DRE-2028677 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028677.1 Reactome Database ID Release 82 10410018 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410018 Reactome R-DRE-2028690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028690.1 GO 0004674 GO molecular function Reactome Database ID Release 82 10410019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410019 Reactome Database ID Release 82 10410023 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10410023 Reactome R-DRE-2028675 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-2028675.1 Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK3(MST2)/N (Lee et al. 2001). Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets. 11278283 Pubmed 2001 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Lee, KK Ohyama, T Yajima, N Tsubuki, S Yonehara, S J Biol Chem 276:19276-85 inferred by electronic annotation IEA GO IEA