BioPAX pathway converted from "CDO binds promyogenic cadherins" in the Reactome database.CDO binds promyogenic cadherinsCDO binds promyogenic cadherinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 104312571plasma membraneGO0005886Trans-cadherin homodimers [plasma membrane]Trans-cadherin homodimersReactome DB_ID: 104312552Cadherin:Catenin [plasma membrane]Cadherin:CateninConverted from EntitySet in ReactomeReactome DB_ID: 104312431cytosolGO0005829alpha/beta catenin [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityCTNNA2 [cytosol]CTNNB1 [cytosol]CTNNA1 [cytosol]Reactomehttp://www.reactome.orgGallus gallusNCBI Taxonomy9031UniProtF1P510UniProtA0A1D5NYE8UniProtE1C7M7Converted from EntitySet in ReactomeReactome DB_ID: 104312531Promyogenic cadherins [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityCDH2 [plasma membrane]CDH15 [plasma membrane]UniProtP10288UniProtA0A1D5P5J3Reactome Database ID Release 7510431255Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431255ReactomeR-GGA-4488761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448876.1Reactome Database ID Release 7510431257Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431257ReactomeR-GGA-4488881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-448888.1Reactome DB_ID: 104312311CDO:BOC [plasma membrane]CDO:BOCReactome DB_ID: 104312291UniProt:A0A1D5NW33CDONUniProtA0A1D5NW33Chain Coordinates26EQUAL1287EQUALReactome DB_ID: 104312251UniProt:E1C5M1BOCUniProtE1C5M131EQUAL1114EQUALReactome Database ID Release 7510431231Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431231ReactomeR-GGA-3750941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375094.1Reactome DB_ID: 104312591CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane]CDO:BOC:Trans-cadherin homodimer:cateninReactome DB_ID: 104312571Reactome DB_ID: 104312311Reactome Database ID Release 7510431259Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431259ReactomeR-GGA-3750921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375092.1Reactome Database ID Release 7510431261Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10431261ReactomeR-GGA-3751401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375140.1In myoblasts, CDO forms cis complexes with the cell–cell adhesion molecule N-cadherin, which is itself involved in regulation of myogenesis. These cadherin complexes contain beta- and alpha-catenins which are important for N-cadherin's effect in myoblast. When CDO binds with ligated cadherins, its intracellular region undergoes a change in conformation and/or posttranslational modi?cation that permits its stable association with Bnip-2 and JLP and, consequently, activation of p38.12634428Pubmed2003Promyogenic members of the Ig and cadherin families associate to positively regulate differentiationKang, JSFeinleib, JLKnox, SKetteringham, MAKrauss, RobertProc Natl Acad Sci U S A 100:3989-9420160094Pubmed2010N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38{alpha}/{beta} MAPK signaling in skeletal myoblastsLu, MKrauss, RobertProc Natl Acad Sci U S A15520228Pubmed2004Netrins and neogenin promote myotube formationKang, JSYi, MJZhang, WFeinleib, JLCole, FKrauss, RobertJ Cell Biol 167:493-504inferred by electronic annotationIEAGOIEA