BioPAX pathway converted from "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)" in the Reactome database.1.3.3(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1135351peroxisomal matrixGO0005782dioxygen [ChEBI:15379]dioxygenReactomehttp://www.reactome.orgChEBI15379Reactome DB_ID: 3898931(2S)-pristanoyl-CoA [ChEBI:64039](2S)-pristanoyl-CoA(2S)-pristanoyl-coenzyme A(2S)-2,6,10,14-tetramethylpentadecanoyl-coenzyme A(2S)-2,6,10,14-tetramethylpentadecanoyl-CoAChEBI64039Reactome DB_ID: 1135751hydrogen peroxide [ChEBI:16240]hydrogen peroxideChEBI16240Reactome DB_ID: 3898941(E)-2,3-didehydropristanoyl-CoA [ChEBI:63803](E)-2,3-didehydropristanoyl-CoAtrans-2,3-dehydropristanoyl-CoAtrans-2,3-didehydropristanoyl-CoAChEBI63803PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10433909ACOX3:FAD [peroxisomal matrix]ACOX3:FADReactome DB_ID: 104339071UniProt:E1C1E9ACOX3Gallus gallusNCBI Taxonomy9031UniProtE1C1E9Chain Coordinates1EQUAL700EQUALReactome DB_ID: 1413351FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBI16238Reactome Database ID Release 7510433909Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10433909ReactomeR-GGA-3899051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-389905.1GO0016402GO molecular functionReactome Database ID Release 7510433910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10433910Reactome Database ID Release 7510433912Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10433912ReactomeR-GGA-3898911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-389891.1Peroxisomal ACOX3 catalyzes the reaction of (2S)-pristanoyl-CoA and O2 to form trans-2,3-dehydropristanoyl-CoA and H2O2. ACOX3 protein and enzyme activity have been observed in prostate tumors, but are undetectable in normal prostate tissue as well as in liver and kidney (where ACOX2 catalyzes the oxidation of pristanoyl-CoA) (Zha et al. 2005; Vanhooren et al. 1997). The physiological consequences of this differential gene expression are unknown.9271077Pubmed1997Evidence for the existence of a pristanoyl-CoA oxidase gene in manVanhooren, JCMarynen, PMannaerts, Guy PVan Veldhoven, Paul PBiochem J 325:593-915599942Pubmed2005Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancerZha, SFerdinandusse, SachaHicks, JLDenis, SimoneDunn, TAWanders, Ronald J ALuo, JDe Marzo, AMIsaacs, WBProstate 63:316-23inferred by electronic annotationIEAGOIEA