BioPAX pathway converted from "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane" in the Reactome database.

3.1.3.66

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 1806238

early endosome membraneGO0031901

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [ChEBI:16152]

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

Reactomehttp://www.reactome.orgChEBI16152

Reactome DB_ID: 29356

cytosolGO0005829

water [ChEBI:15377]

water

ChEBI15377

Reactome DB_ID: 29372

hydrogenphosphate [ChEBI:43474]

hydrogenphosphate

[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUP

ChEBI43474

Reactome DB_ID: 1806200

1-phosphatidyl-1D-myo-inositol 3-phosphate [ChEBI:17283]

1-phosphatidyl-1D-myo-inositol 3-phosphate

1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate)PtdIns3PPtdIns-3-PPhosphatidylinositol 3-phosphate

ChEBI17283PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Converted from EntitySet in Reactome

Reactome DB_ID: 10449130

INPP4A/B [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityINPP4A [cytosol]INPP4B [cytosol]

Gallus gallus

NCBI Taxonomy9031UniProtA0A1D5P5C7UniProtA0A1D5PYC2GO0016316

GO molecular function

Reactome Database ID Release 7510449131Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449131Reactome Database ID Release 7510449133Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10449133ReactomeR-GGA-1676162

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-1676162.1At the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).

7608176Pubmed1995The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphataseNorris, FAAuethavekiat, VMajerus, PWJ Biol Chem 270:16128-3315716355Pubmed2005The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membraneIvetac, IMunday, ADKisseleva, MVZhang, XMLuff, STiganis, TWhisstock, JCRowe, TMajerus, PWMitchell, CAMol Biol Cell 16:2218-339295334Pubmed1997The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase familyNorris, FAAtkins, RCMajerus, PWJ Biol Chem 272:23859-64inferred by electronic annotationIEAGOIEA