BioPAX pathway converted from "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments" in the Reactome database.3.2.1.35Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragmentsHyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragmentsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 104544481plasma membraneGO0005886HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane]HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+Reactome DB_ID: 104544371HA:HAR:HYAL2 [plasma membrane]HA:HAR:HYAL2Reactome DB_ID: 104544211UniProt:H9KZ20HYAL2Reactomehttp://www.reactome.orgGallus gallusNCBI Taxonomy9031UniProtH9KZ20Chain Coordinates21EQUAL448EQUALConverted from EntitySet in ReactomeReactome DB_ID: 104544351HARs [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityHMMR [plasma membrane]LYVE1 [plasma membrane]CD44 [plasma membrane]STAB2(1136-2551) [plasma membrane]UniProtA0A1D5P2N3UniProtE1C9I1UniProtA0A1D5PVD2UniProtA0A3Q2UF11Reactome DB_ID: 21608481extracellular regionGO0005576HA [extracellular region]HAHyaluronanHA polymerHyaluronic acidReactome Database ID Release 7510454437Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454437ReactomeR-GGA-21608891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160889.1Reactome DB_ID: 104544461SLC9A1:p-CHP:Ca2+ [plasma membrane]SLC9A1:p-CHP:Ca2+Reactome DB_ID: 104544441p-CHP1:Ca2+ [plasma membrane]p-CHP1:Ca2+Reactome DB_ID: 1406482calcium(2+) [ChEBI:29108]calcium(2+)ChEBI29108Reactome DB_ID: 104544421UniProt:Q5ZM44CHP1UniProtQ5ZM44phosphorylated residue at unknown positionphosphorylated residue [MOD:00696]2EQUAL195EQUALReactome Database ID Release 7510454444Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454444ReactomeR-GGA-53337521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5333752.1Reactome DB_ID: 104355321UniProt:A0A3Q3AS64SLC9A1UniProtA0A3Q3AS641EQUAL815EQUALReactome Database ID Release 7510454446Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454446ReactomeR-GGA-53336821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5333682.1Reactome Database ID Release 7510454448Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454448ReactomeR-GGA-21608911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160891.1Reactome DB_ID: 104544481Reactome DB_ID: 21608941(HA)50 [plasma membrane](HA)50HyaluronanHyaluronic acidPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10454448GO0004415GO molecular functionReactome Database ID Release 7510454451Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454451Reactome Database ID Release 7510454453Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10454453ReactomeR-GGA-21608921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2160892.1In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).16104017Pubmed2005Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysisJedrzejas, MJStern, RProteins 61:227-389712871Pubmed1998HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificityLepperdinger, GStrobl, BKreil, GJ Biol Chem 273:22466-70inferred by electronic annotationIEAGOIEA