BioPAX pathway converted from "AKT-mediated inactivation of FOXO1A" in the Reactome database. AKT-mediated inactivation of FOXO1A AKT-mediated inactivation of FOXO1A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2.7.11.1 AKT phosphorylates FOXO1A AKT phosphorylates FOXO1A This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29358 3 nucleoplasm GO 0005654 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 10372372 1 UniProt:A3RK74 foxo1a Danio rerio NCBI Taxonomy 7955 UniProt A3RK74 Chain Coordinates 1 EQUAL 655 EQUAL Reactome DB_ID: 10372399 1 O-phospho-L-threonine at 24 (in Homo sapiens) 24 EQUAL O-phospho-L-threonine [MOD:00047] O-phospho-L-serine at 256 (in Homo sapiens) 256 EQUAL O-phospho-L-serine [MOD:00046] O-phospho-L-serine at 319 (in Homo sapiens) 319 EQUAL 1 EQUAL 655 EQUAL Reactome DB_ID: 113582 3 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 10372365 p-T,p-S-AKT [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phospho-p-T308,S473-AKT1 [nucleoplasm] UniProt E7EXT6 GO 0004674 GO molecular function Reactome Database ID Release 82 10372366 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10372366 Reactome Database ID Release 82 10375420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10375420 Reactome R-DRE-211164 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-211164.1 One or more of the isoforms of AKT catalyzes the phosphorylation of FOXO1A protein at three sites, threonine-24, serine-256, and serine-319 (Zhang et al. 2002, 2006). This reaction occurs in the nucleoplasm, and thus is dependent on the phosphorylation and nuclear import of AKT in response to upstream regulatory factors (Burgering and Kops 2002). 12228231 Pubmed 2002 Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding Zhang, X Gan, L Pan, H Guo, S He, X Olson, ST Mesecar, A Adam, S Unterman, TG J Biol Chem 277:45276-84 16540465 Pubmed 2006 Kinetic mechanism of AKT/PKB enzyme family Zhang, X Zhang, S Yamane, H Wahl, R Ali, A Lofgren, JA Kendall, RL J Biol Chem 281:13949-56 12114024 Pubmed 2002 Cell cycle and death control: long live Forkheads Burgering, BM Kops, GJ Trends Biochem Sci 27:352-60 inferred by electronic annotation IEA GO IEA Phosphorylated FOXO1A is excluded from the nucleus Phosphorylated FOXO1A is excluded from the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10372399 1 O-phospho-L-threonine at 24 (in Homo sapiens) 24 EQUAL O-phospho-L-serine at 256 (in Homo sapiens) 256 EQUAL O-phospho-L-serine at 319 (in Homo sapiens) 319 EQUAL 1 EQUAL 655 EQUAL Reactome DB_ID: 10375422 1 cytosol GO 0005829 O-phospho-L-threonine at 24 (in Homo sapiens) 24 EQUAL O-phospho-L-serine at 256 (in Homo sapiens) 256 EQUAL O-phospho-L-serine at 319 (in Homo sapiens) 319 EQUAL 1 EQUAL 655 EQUAL Reactome Database ID Release 82 10375424 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10375424 Reactome R-DRE-211178 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-211178.1 Phosphorylated FOXO1A is transported from the nucleoplasm to the cytosol (Zhang et al. 2002). inferred by electronic annotation IEA GO IEA Reactome Database ID Release 82 10469667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10469667 Reactome R-DRE-211163 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-211163.1 GO 2000074 GO biological process The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002). inferred by electronic annotation IEA GO IEA