BioPAX pathway converted from "Parkin binds Ub:UBE2N:UBE2V1" in the Reactome database. Parkin binds Ub:UBE2N:UBE2V1 Parkin binds Ub:UBE2N:UBE2V1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10470713 1 cytosol GO 0005829 Ub:UBE2N:UBE2V1 [cytosol] Ub:UBE2N:UBE2V1 Converted from EntitySet in Reactome Reactome DB_ID: 10361089 1 Ub [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity RPS27A(1-76) [cytosol] UBB(1-76) [cytosol] UBC(533-608) [cytosol] UBB(153-228) [cytosol] UBC(305-380) [cytosol] UBC(229-304) [cytosol] UBC(381-456) [cytosol] UBC(609-684) [cytosol] UBC(153-228) [cytosol] UBC(1-76) [cytosol] UBB(77-152) [cytosol] UBC(77-152) [cytosol] UBC(457-532) [cytosol] UBA52(1-76) [cytosol] zgc:66168 [cytosol] Reactome http://www.reactome.org Danio rerio NCBI Taxonomy 7955 UniProt B0R189 UniProt A0A2R8RR55 UniProt A0A0N4SUD2 UniProt F1QHN6 UniProt Q7SXA3 Reactome DB_ID: 10380540 1 UBE2N:UBE2V1 [cytosol] UBE2N:UBE2V1 Reactome DB_ID: 10380538 1 UniProt:F1R1E9 UniProt F1R1E9 Chain Coordinates 2 EQUAL 147 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10380534 1 Homologues of UBE2N [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity ube2nl [cytosol] UBE2N [cytosol] ube2n [cytosol] UniProt Q7T3F3 UniProt A0A2R8QIN6 UniProt Q803J2 Reactome Database ID Release 83 10380540 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10380540 Reactome R-DRE-202463 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-202463.1 Reactome Database ID Release 83 10470713 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470713 Reactome R-DRE-9640491 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9640491.1 Reactome DB_ID: 10403002 1 UniProt:A0A0H2UKX4 park2 UniProt A0A0H2UKX4 1 EQUAL 465 EQUAL Reactome DB_ID: 10470715 1 Ub:UBE2N:UBE2V1:PRKN [cytosol] Ub:UBE2N:UBE2V1:PRKN Reactome DB_ID: 10470713 1 Reactome DB_ID: 10403002 1 1 EQUAL 465 EQUAL Reactome Database ID Release 83 10470715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470715 Reactome R-DRE-9641092 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9641092.1 Reactome Database ID Release 83 10470717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10470717 Reactome R-DRE-9641089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-9641089.1 Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. Consequently, the E3 ligase PRKN (Parkin) binds this complex and facilitates the addition of more ubiquitin molecules. (Olzmann JA et al. 2007). 17846173 Pubmed 2007 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 Olzmann, James A Li, Lian Chudaev, Maksim V Chen, Jue Perez, Francisco A Palmiter, Richard D Chin, Lih-Shen J. Cell Biol. 178:1025-38 inferred by electronic annotation IEA GO IEA