BioPAX pathway converted from "GPR161 is internalized" in the Reactome database. GPR161 is internalized GPR161 is internalized This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10481442 1 ciliary membrane GO 0060170 UniProt:E1C367 GPR161 Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 UniProt E1C367 Chain Coordinates 1 EQUAL 529 EQUAL Reactome DB_ID: 10482743 1 endocytic vesicle membrane GO 0030666 1 EQUAL 529 EQUAL Reactome Database ID Release 78 10482745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10482745 Reactome R-GGA-5635102 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5635102.1 Hh signaling promotes the removal of the orphan G protein coupled receptor GPR161 from the cilium (Rohatgi et al, 2007). GPR161 is a negative regulator of Hh signaling that is recruited to the cilium through interaction with TULP3 (Mukhopadhyay et al, 2010; Mukhopadhyay et al, 2013). GPR161 thought to act by locally increasing the cAMP levels, promoting PKA activity and thereby favouring the production of the repressor form of the GLI proteins in the absence of Hh ligand. Consistent with this, deletion of GPR161 results in ectopic pathway activation (Mukhopadhyay et al, 2013). The decrease in PKA activity in the cilium after clearance of GPR161 from the ciliary membrane may contribute to the dissociation of the GLI:SUFU complex upon pathway activation, although this remains to formally demonstrated (Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Mukhopadhyay et al, 2014). 20956384 Pubmed 2010 A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Tukachinsky, Hanna Lopez, Lyle V Salic, Adrian J. Cell Biol. 191:415-28 23332756 Pubmed 2013 The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Mukhopadhyay, Saikat Wen, Xiaohui Ratti, Navneet Loktev, Alexander Rangell, Linda Scales, Suzie J Jackson, Peter K Cell 152:210-23 20360384 Pubmed 2010 The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Humke, Eric W Dorn, Karolin V Milenkovic, Ljiljana Scott, Matthew P Rohatgi, Rajat Genes Dev. 24:670-82 24845016 Pubmed 2014 G-protein-coupled receptors, Hedgehog signaling and primary cilia Mukhopadhyay, Saikat Rohatgi, Rajat Semin. Cell Dev. Biol. 20889716 Pubmed 2010 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, Saikat Wen, Xiaohui Chih, Ben Nelson, Christopher D Lane, William S Scales, Suzie J Jackson, Peter K Genes Dev. 24:2180-93 17641202 Pubmed 2007 Patched1 regulates hedgehog signaling at the primary cilium Rohatgi, Rajat Milenkovic, Ljiljana Scott, Matthew P Science 317:372-6 inferred by electronic annotation IEA GO IEA