BioPAX pathway converted from "Sodium/Proton exchangers" in the Reactome database.Sodium/Proton exchangersSodium/Proton exchangersThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Na+/H+ exchanger transport (at cell membrane)Na+/H+ exchanger transport (at cell membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 741131extracellular regionGO0005576sodium(1+) [ChEBI:29101]sodium(1+)Reactomehttp://www.reactome.orgChEBI29101Reactome DB_ID: 701061cytosolGO0005829hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 839101Reactome DB_ID: 3516261PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10435546plasma membraneGO0005886SLC9A1-5 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySLC9A3 [plasma membrane]SLC9A2 [plasma membrane]SLC9A5 [plasma membrane]SLC9A1 [plasma membrane]Gallus gallusNCBI Taxonomy9031UniProtA0A1D5NYQ5UniProtE1BV56UniProtF1NL74UniProtA0A3Q3AS64GO0015385GO molecular functionReactome Database ID Release 7510435547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435547Reactome Database ID Release 7510435549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435549ReactomeR-GGA-4259941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425994.1NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS. 10444453Pubmed1999Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Malakooti, JDahdal, RYSchmidt, LLayden, TJDudeja, PKRamaswamy, KAm J Physiol 277:G383-909933641Pubmed1999Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainBaird, NROrlowski, JSzabó, EZZaun, HCSchultheis, PJMenon, AGShull, GEJ Biol Chem 274:4377-822536298Pubmed1989Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterSardet, CFranchi, APouysségur, JacquesCell 56:271-807631746Pubmed1995Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Brant, SRYun, CHDonowitz, MTse, CMAm J Physiol 269:C198-206inferred by electronic annotationIEAGOIEASLC9A6,7 exchange Na+ for H+ across the early endosome membraneSLC9A6,7 exchange Na+ for H+ across the early endosome membraneNa+/H+ exchanger transport (at early endosome membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 839101Reactome DB_ID: 4259781early endosome lumenGO0031905Reactome DB_ID: 4259711Reactome DB_ID: 701061PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10435525early endosome membraneGO0031901SLC9A6,7 [early endosome membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySLC9A6 [early endosome membrane]UniProtF1NCB2Reactome Database ID Release 7510435526Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435526Reactome Database ID Release 7510435528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435528ReactomeR-GGA-4259831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425983.1NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.11940519Pubmed2002Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondriaBrett, CLWei, YDonowitz, MRao, RAm J Physiol Cell Physiol 282:C1031-4115522866Pubmed2005Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationNakamura, NTanaka, STeko, YMitsui, KKanazawa, HJ Biol Chem 280:1561-72inferred by electronic annotationIEAGOIEANa+/H+ exchanger transport (at trans-golgi membrane)Na+/H+ exchanger transport (at trans-golgi membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 839101Reactome DB_ID: 4259691Golgi lumenGO0005796Reactome DB_ID: 4259581Reactome DB_ID: 701061PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10435557Golgi membraneGO0000139SLC9A7/8 [Golgi membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySLC9A8 [Golgi membrane]SLC9A7 [Golgi membrane]UniProtF1N9A5UniProtA0A1D5NY95Reactome Database ID Release 7510435558Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435558Reactome Database ID Release 7510435560Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435560ReactomeR-GGA-4260151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-426015.1NHE7 and 8 (SLC9A7,8) (Nakamura N et al, 2005) are expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the trans-golgi network.11279194Pubmed2001Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi networkNumata, MOrlowski, JJ Biol Chem 276:17387-94inferred by electronic annotationIEAGOIEASLC9A9 exchanges Na+ for H+ across the late endosome membraneSLC9A9 exchanges Na+ for H+ across the late endosome membraneNa+/H+ exchanger transport (at late endosome membrane)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 839101Reactome DB_ID: 4259991late endosome lumenGO0031906Reactome DB_ID: 4259771Reactome DB_ID: 701061PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10435512late endosome membraneGO0031902UniProt:F1NYM1SLC9A9UniProtF1NYM1Chain Coordinates1EQUAL645EQUALReactome Database ID Release 7510435513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435513Reactome Database ID Release 7510435515Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10435515ReactomeR-GGA-4259651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425965.1NHE9 (SLC9A9) (Nakamura al. 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in the late endosome membrane.inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510489360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10489360ReactomeR-GGA-4259861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-425986.1The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.12845533Pubmed2004Diversity of the mammalian sodium/proton exchanger SLC9 gene familyOrlowski, JGrinstein, SPflugers Arch 447:549-65inferred by electronic annotationIEAGOIEA