BioPAX pathway converted from "DNA polymerase epsilon binds at the origin" in the Reactome database.DNA polymerase epsilon binds at the originDNA polymerase epsilon binds at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 104917111nucleoplasmGO0005654DNA polymerase epsilon [nucleoplasm]DNA polymerase epsilonReactome DB_ID: 104916991UniProt:Q9VRQ7DNApol-epsilon58Reactomehttp://www.reactome.orgDrosophila melanogasterNCBI Taxonomy7227UniProtQ9VRQ7Chain Coordinates1EQUAL527EQUALReactome DB_ID: 104917041UniProt:Q9V444Chrac-14UniProtQ9V4442EQUAL147EQUALReactome DB_ID: 104916941UniProt:Q9VCN1DNApol-epsilon255UniProtQ9VCN11EQUAL2286EQUALReactome DB_ID: 104917091UniProt:Q9W256Mes4UniProtQ9W2562EQUAL117EQUALReactome Database ID Release 7510491711Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491711ReactomeR-DME-684831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68483.1Reactome DB_ID: 684191origin of replication [nucleoplasm]origin of replicationARSautonomously replicating sequenceoriginReactome DB_ID: 104917131DNA polymerase epsilon:origin complex [nucleoplasm]DNA polymerase epsilon:origin complexReactome DB_ID: 104917111Reactome DB_ID: 684191Reactome Database ID Release 7510491713Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491713ReactomeR-DME-684851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68485.1Reactome Database ID Release 7510491880Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491880ReactomeR-DME-689601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68960.1At the beginning of this reaction, 1 molecule of 'origin of replication', and 1 molecule of 'DNA polymerase epsilon' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon:origin complex' is present.<br><br> <br>12045100Pubmed2002DNA replication in eukaryotic cells.Bell, SPDutta, AAnnu Rev Biochem 71:333-74inferred by electronic annotationIEAGOIEAACTIVATIONReactome Database ID Release 7510491780Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491780Reactome DB_ID: 10491777CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4Reactome DB_ID: 104917361RPA1-4 [nucleoplasm]RPA1-4Reactome DB_ID: 104917321UniProt:Q9VIH1RPA2UniProtQ9VIH11EQUAL261EQUALReactome DB_ID: 104917271UniProt:Q9VYW3RPA3UniProtQ9VYW31EQUAL121EQUALReactome DB_ID: 104917221Ghost homologue of RPA1 [nucleoplasm]Ghost homologue of RPA1Reactome DB_ID: 1049173411EQUAL270EQUALReactome Database ID Release 7510491736Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491736ReactomeR-DME-685671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68567.1Reactome DB_ID: 104917751CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complex:CDC45Reactome DB_ID: 104917731CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complexReactome DB_ID: 104917501CDK [nucleoplasm]CDKReactome DB_ID: 104917431Ghost homologue of cyclin [nucleoplasm]Ghost homologue of cyclinReactome DB_ID: 104917481UniProt:P23573Cdk2UniProtP235731EQUAL298EQUALReactome Database ID Release 7510491750Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491750ReactomeR-DME-683801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68380.1Reactome DB_ID: 104917621DDK [nucleoplasm]DDKReactome DB_ID: 104917551UniProt:Q9W3Y1Cdc7UniProtQ9W3Y11EQUAL574EQUALReactome DB_ID: 104917601UniProt:Q9NK54chifUniProtQ9NK541EQUAL674EQUALReactome Database ID Release 7510491762Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491762ReactomeR-DME-683881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68388.1Reactome DB_ID: 104917711MCM10:active pre-replicative complex [nucleoplasm]MCM10:active pre-replicative complexReactome DB_ID: 104917691active pre-replicative complex [nucleoplasm]active pre-replicative complexReactome DB_ID: 104916611MCM2-7 [nucleoplasm]MCM2-7Reactome DB_ID: 104916441UniProt:Q9VGW6Mcm5UniProtQ9VGW61EQUAL734EQUALReactome DB_ID: 104916591UniProt:P49735Mcm2UniProtP497352EQUAL904EQUALReactome DB_ID: 104916491UniProt:Q9V461Mcm6UniProtQ9V4611EQUAL821EQUALReactome DB_ID: 104916541UniProt:Q9XYU0Mcm7UniProtQ9XYU02EQUAL719EQUALReactome DB_ID: 104916341UniProt:Q9XYU1Mcm3UniProtQ9XYU12EQUAL808EQUALReactome DB_ID: 104916391UniProt:Q26454dpaUniProtQ264542EQUAL863EQUALReactome Database ID Release 7510491661Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491661ReactomeR-DME-685581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68558.1Reactome DB_ID: 104913631CDC6:ORC:origin complex [nucleoplasm]CDC6:ORC:origin complexReactome DB_ID: 104913611ORC:origin of replication [nucleoplasm]ORC:origin of replicationReactome DB_ID: 104913211UniProt:Q9Y1B2Orc6UniProtQ9Y1B21EQUAL252EQUALReactome DB_ID: 104913031UniProt:Q9W102Orc4UniProtQ9W1021EQUAL436EQUALReactome DB_ID: 104913121UniProt:O16810Orc1UniProtO168101EQUAL861EQUALReactome DB_ID: 104913591Orc2 associated with MCM8 [nucleoplasm]Orc2 associated with MCM8Reactome DB_ID: 104913571UniProt:Q9VF30recUniProtQ9VF301EQUAL840EQUALReactome DB_ID: 104912831UniProt:Q24168Orc2UniProtQ241681EQUAL577EQUALReactome Database ID Release 7510491359Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491359ReactomeR-DME-1769701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-176970.1Reactome DB_ID: 104912781UniProt:Q7K2L1Orc3UniProtQ7K2L11EQUAL711EQUALReactome DB_ID: 104912941UniProt:Q24169Orc5UniProtQ241691EQUAL435EQUALReactome DB_ID: 684191Reactome Database ID Release 7510491361Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491361ReactomeR-DME-685401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68540.1Reactome DB_ID: 104913301UniProt:Q9VSM9Cdc6UniProtQ9VSM91EQUAL560EQUALReactome Database ID Release 7510491363Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491363ReactomeR-DME-685431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68543.1Reactome Database ID Release 7510491769Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491769ReactomeR-DME-1565621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-156562.1Reactome DB_ID: 104917671UniProt:Q9VIE6Mcm10UniProtQ9VIE61EQUAL875EQUALReactome Database ID Release 7510491771Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491771ReactomeR-DME-1565641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-156564.1Reactome Database ID Release 7510491773Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491773ReactomeR-DME-685611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68561.1Reactome DB_ID: 104917411UniProt:O96989Cdc45UniProtO969891EQUAL566EQUALReactome Database ID Release 7510491775Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491775ReactomeR-DME-685641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68564.1Reactome Database ID Release 7510491777Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491777ReactomeR-DME-685681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68568.1