BioPAX pathway converted from "Metabolism of ingested SeMet, Sec, MeSec into H2Se" in the Reactome database.Metabolism of ingested SeMet, Sec, MeSec into H2SeMetabolism of ingested SeMet, Sec, MeSec into H2SeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>SeMet is converted to AdoSeMet by MATSeMet is converted to AdoSeMet by MATThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 293561cytosolGO0005829water [ChEBI:15377]waterReactomehttp://www.reactome.orgChEBI15377Reactome DB_ID: 53577071L-selenomethionine [ChEBI:30021]L-selenomethionineChEBI30021Reactome DB_ID: 1135921ATP(4-) [ChEBI:30616]ATP(4-)Adenosine 5'-triphosphateatpATPChEBI30616Reactome DB_ID: 53576521L-adenosylselenomethionine [ChEBI:9066]L-adenosylselenomethionineSe-adenosyl-L-selenomethionineSe-AdenosylselenomethionineChEBI9066Reactome DB_ID: 293721phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBI18367Reactome DB_ID: 1112941diphosphoric acid [ChEBI:29888]diphosphoric acidChEBI29888PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10411858MAT1A multimers [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGO0098601GO molecular functionReactome Database ID Release 7010458087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458087Reactome Database ID Release 7010458089Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458089ReactomeR-GGA-24085511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408551.1Methionine adenosyltransferases (MAT multimers) consisting of a S-adenosylmethionine synthase isoform type-1 (MAT1A) homodimer and a MAT1A: S-adenosylmethionine synthase isoform type-2 (MAT2A) heterodimer are responsible for the conversion of selenomethionine (SeMet) and ATP into Se-adenosylselenomethionine (AdoSeMet), orthophosphate (Pi), and diphosphate (PPi) (Kajander et al. 1990).2339986Pubmed1990Effects of selenomethionine on cell growth and on S-adenosylmethionine metabolism in cultured malignant cellsKajander, E OHarvima, R JKauppinen, LAkerman, K KMartikainen, HPajula, R LKärenlampi, S OBiochem. J. 267:767-74inferred by electronic annotationIEAGOIEA4.4.1.16Sec is reduced to H2Se by PXLP-K259-SCLY dimerSec is reduced to H2Se by PXLP-K259-SCLY dimerThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 53590161reduced acceptor [cytosol]reduced acceptorXH2Reactome DB_ID: 53576971L-selenocysteine [ChEBI:16633]L-selenocysteineChEBI16633Reactome DB_ID: 294321L-alanine zwitterion [ChEBI:57972]L-alanine zwitterionQNAYBMKLOCPYGJ-REOHCLBHSA-NInChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1(2S)-2-ammoniopropanoate89.09320C3H7NO2(2S)-2-azaniumylpropanoateL-alanineC[C@H]([NH3+])C([O-])=OChEBI57972Reactome DB_ID: 53590111acceptor [cytosol]acceptorXReactome DB_ID: 53576601selane [ChEBI:16503]selaneChEBI16503PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10458083PXLP-K259-SCLY dimer [cytosol]PXLP-K259-SCLY dimerReactome DB_ID: 104580812UniProt:E1BZJ9Gallus gallusNCBI Taxonomy9031UniProtE1BZJ9N6-pyridoxal phosphate-L-lysine at 259 (in Homo sapiens)259EQUALN6-pyridoxal phosphate-L-lysine [MOD:00128]Chain Coordinates1EQUAL445EQUALReactome Database ID Release 7010458083Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458083ReactomeR-GGA-53590181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5359018.1GO0009000GO molecular functionReactome Database ID Release 7010458084Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458084Reactome Database ID Release 7010458086Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10458086ReactomeR-GGA-24085241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408524.1Selenocysteine lyase (SCLY) homodimer is involved in the reduction of selenocysteine (Sec) to hydrogen selenide (H2Se) and alanine (Ala) (Daher and Van Lente 1992).1483038Pubmed1992Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrationsDaher, RVan Lente, FJ Trace Elem Electrolytes Health Dis 6:189-9420164179Pubmed2010Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyaseOmi, RieKurokawa, SuguruMihara, HisaakiHayashi, HideyukiGoto, MMiyahara, IKurihara, TatsuoHirotsu, KEsaki, NobuyoshiJ. Biol. Chem. 285:12133-9inferred by electronic annotationIEAGOIEAReactome Database ID Release 7010505082Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10505082ReactomeR-GGA-24085081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2408508.1GO0001887GO biological processInorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) through the trans-selenation pathway, selenocysteine lyase (SCLY), and cystathionine gamma-lyase (CTH).20383543Pubmed2011Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compoundsPinto, John TLee, Jeong-InSinha, RaghuMacEwan, Melanie ECooper, Arthur J LAmino Acids 41:29-416456763Pubmed1981Enzymatic synthesis of selenocysteine in rat liverEsaki, NNakamura, TTanaka, HSuzuki, TMorino, YSoda, KBiochemistry 20:4492-6inferred by electronic annotationIEAGOIEA