BioPAX pathway converted from "SKI complexes with the Smad complex, suppressing BMP2 signalling" in the Reactome database.SKI complexes with the Smad complex, suppressing BMP2 signallingSKI complexes with the Smad complex, suppressing BMP2 signallingThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 105063541nucleoplasmGO0005654p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]p-2S-SMAD1/5/8:SMAD4Reactome DB_ID: 105063482UniProt:P42003MadReactomehttp://www.reactome.orgDrosophila melanogasterNCBI Taxonomy7227UniProtP42003O-phospho-L-serine at 463 (in Homo sapiens)463EQUALO-phospho-L-serine [MOD:00046]O-phospho-L-serine at 465 (in Homo sapiens)465EQUALChain Coordinates1EQUAL465EQUALReactome DB_ID: 105024901UniProt:O62609MedUniProtO626091EQUAL552EQUALReactome Database ID Release 7510506354Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10506354ReactomeR-DME-2014501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-201450.1Reactome DB_ID: 105025011UniProt:Q00G30SnooUniProtQ00G301EQUAL728EQUALReactome DB_ID: 105063561p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm]p-2S-SMAD1/5/8:SMAD4:SKIReactome DB_ID: 105063541Reactome DB_ID: 1050250111EQUAL728EQUALReactome Database ID Release 7510506356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10506356ReactomeR-DME-2014271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-201427.1Reactome Database ID Release 7510506358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10506358ReactomeR-DME-2014231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-201423.1GO0030514GO biological processSKI and SKIL (SNO) are able to recruit NCOR and possibly other transcriptional repressors to SMAD2/3:SMAD4 complex, inhibiting SMAD2/3:SMAD4-mediated transcription (Sun et al. 1999, Luo et al. 1999, Strochein et al. 1999). Experimental findings suggest that SMAD2 and SMAD3 may target SKI and SKIL for degradation (Strochein et al. 1999, Sun et al. 1999 PNAS, Bonni et al. 2001), and that the ratio of SMAD2/3 and SKI/SKIL determines the outcome (inhibition of SMAD2/3:SMAD4-mediated transcription or degradation of SKI/SKIL). SKI and SKIL are overexpressed in various cancer types and their oncogenic effect is connected with their ability to inhibit signaling by TGF-beta receptor complex. 11121043Pubmed2000Ski represses bone morphogenic protein signaling in Xenopus and mammalian cellsWang, WMariani, FVHarland, RMLuo, KProc Natl Acad Sci U S A 97:14394-910531062Pubmed1999Negative feedback regulation of TGF-beta signaling by the SnoN oncoproteinStroschein, SLWang, WeiZhou, SZhou, QLuo, KScience 286:771-410485843Pubmed1999The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signalingLuo, KStroschein, SLWang, WeiChen, DanMartens, EZhou, SZhou, QGenes Dev 13:2196-20610549282Pubmed1999Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signalingSun, YLiu, XEaton, ENLane, WSLodish, HFWeinberg, RAMol Cell 4:499-50911389444Pubmed2001TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradationBonni, SWang, HRCausing, CGKavsak, PStroschein, SLLuo, KWrana, JLNat Cell Biol 3:587-9510535941Pubmed1999SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signalingSun, YLiu, XNg-Eaton, ELodish, HFWeinberg, RAProc Natl Acad Sci U S A 96:12442-7inferred by electronic annotationIEAGOIEA