BioPAX pathway converted from "RHOD GAPs stimulate RHOD GTPase activity" in the Reactome database. RHOD GAPs stimulate RHOD GTPase activity RHOD GAPs stimulate RHOD GTPase activity This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29356 1 cytosol GO 0005829 water [ChEBI:15377] water Reactome http://www.reactome.org ChEBI 15377 Reactome DB_ID: 10568734 1 plasma membrane GO 0005886 RHOD:GTP [plasma membrane] RHOD:GTP Reactome DB_ID: 29438 1 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI 37565 Reactome DB_ID: 10568732 1 UniProt:Q28GP9 pias1 Xenopus tropicalis NCBI Taxonomy 8364 UniProt Q28GP9 Chain Coordinates 1 EQUAL 207 EQUAL Reactome Database ID Release 83 10568734 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568734 Reactome R-XTR-9013453 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9013453.1 Reactome DB_ID: 10568730 1 RHOD:GDP [cytosol] RHOD:GDP Reactome DB_ID: 10568728 1 1 EQUAL 207 EQUAL Reactome DB_ID: 29420 1 GDP(3-) [ChEBI:58189] GDP(3-) guanosine 5'-diphosphate(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate trianion GDP GDP trianion guanosine 5'-diphosphate ChEBI 58189 Reactome Database ID Release 83 10568730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568730 Reactome R-XTR-9013446 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9013446.1 Reactome DB_ID: 29372 1 hydrogenphosphate [ChEBI:43474] hydrogenphosphate [PO3(OH)](2-) HYDROGENPHOSPHATE ION hydrogen phosphate [P(OH)O3](2-) HPO4(2-) phosphate INORGANIC PHOSPHATE GROUP ChEBI 43474 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 10568739 RHOD GAPs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity arhgap1 [cytosol] arhgap26 [cytosol] arhgap32 [cytosol] UniProt Q66IH1 UniProt A0A6I8QLX2 UniProt A0A6I8QN72 GO 0005096 GO molecular function Reactome Database ID Release 83 10568740 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568740 Reactome Database ID Release 83 10568742 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10568742 Reactome R-XTR-9013437 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-9013437.1 The following GTPase activating proteins (GAPs) were shown to bind RHOD and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOD:GTP complex to the inactive RHOD:GDP complex (the study by Bagci et al. 2020 is cited as supporting evidence since it only examined binding of GAPs to active RHOD without testing for RHOD-directed GAP activity):<br>ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)<br>ARHGAP26 (Amin et al. 2016)<br>ARHGAP32 (Paul et al. 2017; supported by Bagci et al. 2020)<br>ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)<br><br>The following GAPs were shown to bind RHOD and stimulate its GTPase activity in some but not all studies or were shown by Bagci et al. 2020 to bind to active RHOD without testing for RHOD-directed GAP activity and are annotated as candidate RHOD GAPs:<br>ARHGAP5 (Bagci et al. 2020)<br>ARHGAP12 (Bagci et al. 2020)<br>ARHGAP17 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)<br>ARHGAP21 (Bagci et al. 2020)<br>ARHGAP39 (Bagci et al. 2020)<br>DEPDC1B (Bagci et al. 2020)<br>PIK3R1 (Bagci et al. 2020)<br>PIK3R2 (Bagci et al. 2020)<br>RACGAP1 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)<br><br>The following GAPs do not act on RHOD or were shown by Bagci et al. 2020 to not bind to active RHOD:<br>ABR (Amin et al. 2016; Bagci et al. 2020)<br>ARAP2 (Bagci et al. 2020)<br>ARAP3 (Bagci et al. 2020)<br>ARHGAP29 (Bagci et al. 2020)<br>ARHGAP31 (Bagci et al. 2020)<br>ARHGAP42 (Bagci et al. 2020)<br>BCR (Bagci et al. 2020)<br>DLC1 (Amin et al. 2016)<br>MYO9A (Bagci et al. 2020)<br>MYO9B (Bagci et al. 2020)<br>OPHN1 (Amin et al. 2016; Bagci et al. 2020)<br>SRGAP2 (Bagci et al. 2020)<br>STARD13 (Amin et al. 2016)<br>STARD8 (Amin et al. 2016)<br>SYDE1 (Bagci et al. 2020) 27852748 Pubmed 2017 Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners Paul, Florian Zauber, Henrik von Berg, Laura Rocks, Oliver Daumke, Oliver Selbach, Matthias Mol. Cell Proteomics 16:73-85 31871319 Pubmed 2020 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, Halil Sriskandarajah, Neera Robert, Amélie Boulais, Jonathan Elkholi, Islam E Tran, Viviane Lin, Zhen-Yuan Thibault, Marie-Pier Dubé, Nadia Faubert, Denis Hipfner, David R Gingras, Anne-Claude Cote, Jean-Francois Nat. Cell Biol. 22:120-134 27481945 Pubmed 2016 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS Amin, Ehsan Jaiswal, Mamta Derewenda, Urszula Reis, Katarina Nouri, Kazem Koessmeier, Katja T Aspenström, Pontus Somlyo, Avril V Dvorsky, Radovan Ahmadian, Mohammad R J. Biol. Chem. 291:20353-71 inferred by electronic annotation IEA GO IEA