BioPAX pathway converted from "CBL binds to GRB2" in the Reactome database.CBL binds to GRB2CBL binds to GRB2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 105752491cytosolGO0005829UniProt:P29355sem-5Reactomehttp://www.reactome.orgCaenorhabditis elegansNCBI Taxonomy6239UniProtP29355Chain Coordinates1EQUAL217EQUALReactome DB_ID: 105810671UniProt:Q19019sli-1UniProtQ190191EQUAL906EQUALReactome DB_ID: 105812121CBL:GRB2 [cytosol]CBL:GRB2Reactome DB_ID: 1057524911EQUAL217EQUALReactome DB_ID: 1058106711EQUAL906EQUALReactome Database ID Release 7510581212Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10581212ReactomeR-CEL-1829101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182910.1Reactome Database ID Release 7510581214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10581214ReactomeR-CEL-1830521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-183052.1CBL binds multiple signalling proteins including GRB2. The CBL:GRB2 complex translocates to the plasma membrane where it can bind to GRB2-specific docking sites on the EGF receptor.8621719Pubmed1996p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinasePanchamoorthy, GFukazawa, TMiyake, SSoltoff, SReedquist, KDruker, BShoelson, SCantley, Lewis CBand, HJ Biol Chem 271:3187-94inferred by electronic annotationIEAGOIEA