BioPAX pathway converted from "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol" in the Reactome database.SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosolSLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosolNa+, K+/2Cl- cotransportThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 741261extracellular regionGO0005576potassium(1+) [ChEBI:29103]potassium(1+)K+PotassiumReactomehttp://www.reactome.orgChEBI29103Reactome DB_ID: 741131sodium(1+) [ChEBI:29101]sodium(1+)ChEBI29101Reactome DB_ID: 1889722chloride [ChEBI:17996]chlorideChEBI17996Reactome DB_ID: 839101cytosolGO0005829Reactome DB_ID: 3520222Reactome DB_ID: 298041PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10591958plasma membraneGO0005886SLC12A1,2 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitynkcc-1 [plasma membrane]SLC12A1 [plasma membrane]nkcc-1 [plasma membrane]Caenorhabditis elegansNCBI Taxonomy6239UniProtH8ESD5UniProtP34261GO0008511GO molecular functionReactome Database ID Release 7510591959Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10591959Reactome Database ID Release 7510591961Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10591961ReactomeR-CEL-4260861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-426086.1Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.7629105Pubmed1995Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colonPayne, JAXu, JCHaas, MLytle, CYWard, DForbush B, 3rdJ Biol Chem 270:17977-858640224Pubmed1996Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2Simon, DBKaret, FEHamdan, JMDiPietro, ASanjad, SALifton, RPNat Genet 13:183-8inferred by electronic annotationIEAGOIEA