BioPAX pathway converted from "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" in the Reactome database.4.2.1.1Carbonic anhydrase dehydrates bicarbonate (mitochondria)Carbonic anhydrase dehydrates bicarbonate (mitochondria)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 298961mitochondrial matrixGO0005759hydrogencarbonate [ChEBI:17544]hydrogencarbonateReactomehttp://www.reactome.orgChEBI17544Reactome DB_ID: 1135291hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 1135211water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 293761carbon dioxide [ChEBI:16526]carbon dioxideChEBI16526PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10603787CA5A,B:Zinc [mitochondrial matrix]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGO0004089GO molecular functionReactome Database ID Release 7510603788Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603788Reactome Database ID Release 7510603790Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603790ReactomeR-CEL-14750281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1475028.1Carbonic anhydrase VA (CA5A, Nagao et al. 1993, Franchi et al. 2003, Nishimori et al. 2007) and carbonic anhydrase VB (CA5B, Fujikawa-Adachi et al. 1999, Nishimori et al. 2005, Nishimori et al. 2007) dehydrate bicarbonate in mitochondria to yield water and carbon dioxide (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.16302824Pubmed2005Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitorsNishimori, IVullo, DInnocenti, AScozzafava, AMastrolorenzo, ASupuran, CTJ Med Chem 48:7860-69336012Pubmed1997Structure and mechanism of carbonic anhydraseLindskog, SPharmacol Ther 74:1-2014611844Pubmed2003Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anionsFranchi, MVullo, DGallori, EAntel, JWurl, MScozzafava, ASupuran, CTBioorg Med Chem Lett 13:2857-618356065Pubmed1993Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16Nagao, YPlatero, JSWaheed, ASly, William SProc Natl Acad Sci U S A 90:7623-710409679Pubmed1999Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome xFujikawa-Adachi, KNishimori, ITaguchi, TOnishi, SJ Biol Chem 274:21228-3317761422Pubmed2007Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very differentNishimori, IInnocenti, AVullo, DScozzafava, ASupuran, CTBioorg Med Chem 15:6742-7inferred by electronic annotationIEAGOIEA