BioPAX pathway converted from "EP300 acetylates RUNX3" in the Reactome database. EP300 acetylates RUNX3 EP300 acetylates RUNX3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 113560 2 nucleoplasm GO 0005654 acetyl-CoA(4-) [ChEBI:57288] acetyl-CoA(4-) 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) acetyl-CoA acetyl-CoA tetraanion acetyl-coenzyme A(4-) AcCoA(4-) Reactome http://www.reactome.org ChEBI 57288 Reactome DB_ID: 10606673 1 RUNX3:CBFB:EP300 [nucleoplasm] RUNX3:CBFB:EP300 Reactome DB_ID: 10602240 1 RUNX3:CBFB [nucleoplasm] RUNX3:CBFB Reactome DB_ID: 10602238 1 UniProt:A0A3Q2UKH7 RUNX3 Gallus gallus NCBI Taxonomy 9031 UniProt A0A3Q2UKH7 Chain Coordinates 1 EQUAL 415 EQUAL Reactome DB_ID: 10602223 1 UniProt:F1NQP4 CBFB UniProt F1NQP4 1 EQUAL 182 EQUAL Reactome Database ID Release 81 10602240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602240 Reactome R-GGA-8865463 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8865463.1 Reactome DB_ID: 10558531 1 UniProt:E1BSS0 EP300 UniProt E1BSS0 2 EQUAL 2414 EQUAL Reactome Database ID Release 81 10606673 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10606673 Reactome R-GGA-8951952 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8951952.1 Reactome DB_ID: 10606683 1 Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] Ac-K94,K171-RUNX3:CBFB:EP300 Reactome DB_ID: 10606681 1 Ac-K94,K171-RUNX3:CBFB [nucleoplasm] Ac-K94,K171-RUNX3:CBFB Reactome DB_ID: 10606679 1 N6-acetyl-L-lysine at 94 (in Homo sapiens) 94 EQUAL N6-acetyl-L-lysine [MOD:00064] N6-acetyl-L-lysine at 171 (in Homo sapiens) 171 EQUAL 1 EQUAL 415 EQUAL Reactome DB_ID: 10602223 1 1 EQUAL 182 EQUAL Reactome Database ID Release 81 10606681 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10606681 Reactome R-GGA-8951964 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8951964.1 Reactome DB_ID: 10558531 1 2 EQUAL 2414 EQUAL Reactome Database ID Release 81 10606683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10606683 Reactome R-GGA-8951959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8951959.1 Reactome DB_ID: 2485002 2 coenzyme A(4-) [ChEBI:57287] coenzyme A(4-) CoA 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] diphosphate} ChEBI 57287 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10606673 GO 0061733 GO molecular function Reactome Database ID Release 81 10606684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10606684 Reactome Database ID Release 81 10606686 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10606686 Reactome R-GGA-8951966 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8951966.1 EP300 (p300) histone acetyltransferase acetylates RUNX3 on lysine residues K94 and K171 (Lee et al. 2013), and probably other lysines (Jin et al. 2004). EP300-mediated acetylation of RUNX3 is positively regulated by TGF-beta treatment. Besides increasing the transcriptional activity of RUNX3, EP300-mediated acetylation also increases the half-life of RUNX3, as it interferes with SMURF-mediated ubiquitination and subsequent degradation of RUNX3 (Jin et al. 2004). 15138260 Pubmed 2004 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation Jin, Yun-Hye Jeon, Eun-Joo Li, Qing-Lin Lee, Yong Hee Choi, Joong-Kook Kim, Wun-Jae Lee, Kwang-Youl Bae, Suk-Chul J. Biol. Chem. 279:29409-17 24229708 Pubmed 2013 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma Lee, You-Soub Lee, Jung-Won Jang, Ju-Won Chi, Xin-Zi Kim, Jang-Hyun Li, Ying-Hui Kim, Min-Kyu Kim, Da-Mi Choi, Byeung-Sub Kim, EG Chung, Jin-Haeng Lee, Ok-Jun Lee, You-Mie Suh, Joo-Won Chuang, Linda Shyue Huey Ito, Yoshiaki Bae, Suk-Chul Cancer Cell 24:603-16 inferred by electronic annotation IEA GO IEA ACTIVATION Reactome Database ID Release 81 10604396 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10604396 Reactome DB_ID: 10537607 extracellular region GO 0005576 Dimeric TGFB1 [extracellular region] Dimeric TGFB1 Reactome DB_ID: 10537605 2 UniProt:H9CX01 TGFB1 UniProt H9CX01 279 EQUAL 390 EQUAL Reactome Database ID Release 81 10537607 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10537607 Reactome R-GGA-170852 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-170852.1