BioPAX pathway converted from "Loss of Nlp from mitotic centrosomes" in the Reactome database. Loss of Nlp from mitotic centrosomes Loss of Nlp from mitotic centrosomes This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2.7.11.1 Plk1-mediated phosphorylation of Nlp Plk1-mediated phosphorylation of Nlp This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10549212 1 cytosol GO 0005829 centrosome [cytosol] centrosome Reactome DB_ID: 10549126 1 Ghost homologue of CEP152 [cytosol] Ghost homologue of CEP152 Reactome http://www.reactome.org Reactome DB_ID: 10549124 1 UniProt:E1C8Q1 CEP164 Gallus gallus NCBI Taxonomy 9031 UniProt E1C8Q1 Chain Coordinates 1 EQUAL 1460 EQUAL Reactome DB_ID: 10537454 1 UniProt:F1NBD7 CDK1 UniProt F1NBD7 1 EQUAL 297 EQUAL Reactome DB_ID: 10549154 1 Ghost homologue of CEP72 [cytosol] Ghost homologue of CEP72 Reactome DB_ID: 10549060 1 UniProt:F1NGJ4 PCNT UniProt F1NGJ4 1 EQUAL 3336 EQUAL Reactome DB_ID: 10549056 1 UniProt:F1NM71 CETN1 UniProt F1NM71 1 EQUAL 172 EQUAL Reactome DB_ID: 10549136 1 UniProt:F1NHK0 CCP110 UniProt F1NHK0 1 EQUAL 1012 EQUAL Reactome DB_ID: 10534278 1 UniProt:A0A1I7Q3Z7 MAPRE1 UniProt A0A1I7Q3Z7 2 EQUAL 268 EQUAL Reactome DB_ID: 10549180 1 Ghost homologue of NINL [cytosol] Ghost homologue of NINL Reactome DB_ID: 10534554 1 UniProt:F1NKL4 DYNC1H1 UniProt F1NKL4 1 EQUAL 4646 EQUAL Reactome DB_ID: 10549038 1 UniProt:A0A1D5NU82 TUBG1 UniProt A0A1D5NU82 1 EQUAL 451 EQUAL Reactome DB_ID: 10534302 1 UniProt:Q5ZMC9 NDE1 UniProt Q5ZMC9 1 EQUAL 346 EQUAL Reactome DB_ID: 10539916 1 UniProt:A0A1D5NW27 TUBA1A UniProt A0A1D5NW27 1 EQUAL 451 EQUAL Reactome DB_ID: 10549170 1 UniProt:F1P288 FGFR1OP UniProt F1P288 1 EQUAL 399 EQUAL Reactome DB_ID: 10549034 1 UniProt:F1P0W9 NEDD1 UniProt F1P0W9 1 EQUAL 660 EQUAL Reactome DB_ID: 10549148 1 UniProt:E1BZ70 CEP76 UniProt E1BZ70 1 EQUAL 659 EQUAL Reactome DB_ID: 10549178 1 UniProt:A0A1D5PYD8 SSNA1 UniProt A0A1D5PYD8 1 EQUAL 119 EQUAL Reactome DB_ID: 10549114 1 UniProt:A0A1L1RLW1 ALMS1 UniProt A0A1L1RLW1 1 EQUAL 4167 EQUAL Reactome DB_ID: 10530796 1 UniProt:Q5ZMT0 YWHAE UniProt Q5ZMT0 1 EQUAL 255 EQUAL Reactome DB_ID: 10549102 1 UniProt:Q5ZK19 DCTN3 UniProt Q5ZK19 1 EQUAL 186 EQUAL Reactome DB_ID: 10549118 1 UniProt:A0A1D5PSP1 CEP192 UniProt A0A1D5PSP1 1 EQUAL 1941 EQUAL Reactome DB_ID: 10549068 1 UniProt:A0A3Q2U1N8 AKAP9 UniProt A0A3Q2U1N8 1 EQUAL 3911 EQUAL Reactome DB_ID: 10549174 1 UniProt:E1C065 CEP41 UniProt E1C065 1 EQUAL 373 EQUAL Reactome DB_ID: 10539932 1 UniProt:A0A1L1RJP8 TUBA4A UniProt A0A1L1RJP8 1 EQUAL 448 EQUAL Reactome DB_ID: 10549098 1 extracellular region GO 0005576 Ghost homologue of TUBB [extracellular region] Ghost homologue of TUBB Reactome DB_ID: 10549158 1 UniProt:E1BXW8 CEP70 UniProt E1BXW8 1 EQUAL 597 EQUAL Reactome DB_ID: 10534270 1 UniProt:A0A1D5P7I0 CLASP1 UniProt A0A1D5P7I0 1 EQUAL 1538 EQUAL Reactome DB_ID: 10534564 1 UniProt:F1P3C8 DYNC1I2 UniProt F1P3C8 1 EQUAL 638 EQUAL Reactome DB_ID: 10549070 1 Ghost homologue of CDK5RAP2 [cytosol] Ghost homologue of CDK5RAP2 Reactome DB_ID: 10549082 1 UniProt:A0A1D5PIH8 CEP250 UniProt A0A1D5PIH8 1 EQUAL 2442 EQUAL Reactome DB_ID: 10549130 1 UniProt:A0A3Q2UHN2 CEP131 UniProt A0A3Q2UHN2 1 EQUAL 1083 EQUAL Reactome DB_ID: 10539952 1 UniProt:F1NYB1 TUBB4B UniProt F1NYB1 1 EQUAL 445 EQUAL Reactome DB_ID: 10532730 1 UniProt:F1NC65 PRKAR2B UniProt F1NC65 2 EQUAL 418 EQUAL Reactome DB_ID: 10530766 1 UniProt:F1NMY1 YWHAG UniProt F1NMY1 1 EQUAL 247 EQUAL Reactome DB_ID: 10549092 1 Ghost homologue of PLK4 [cytosol] Ghost homologue of PLK4 Reactome DB_ID: 10549050 1 UniProt:Q5ZLL1 CSNK1E UniProt Q5ZLL1 1 EQUAL 416 EQUAL Reactome DB_ID: 10534568 1 UniProt:F1N8L5 DYNLL1 UniProt F1N8L5 1 EQUAL 89 EQUAL Reactome DB_ID: 10538963 1 UniProt:F1NI69 NEK2 UniProt F1NI69 1 EQUAL 445 EQUAL Reactome DB_ID: 10549046 1 UniProt:A0A1D5NXQ4 CSNK1D UniProt A0A1D5NXQ4 1 EQUAL 415 EQUAL Reactome DB_ID: 10549074 1 UniProt:A0A1D5PL93 CNTRL UniProt A0A1D5PL93 1 EQUAL 2325 EQUAL Reactome DB_ID: 10543056 1 UniProt:A0A1L1RND0 HSP90AA1 UniProt A0A1L1RND0 2 EQUAL 732 EQUAL Reactome DB_ID: 10549210 1 HAUS complex [cytosol] HAUS complex Reactome DB_ID: 10549198 1 Ghost homologue of HAUS5 [cytosol] Ghost homologue of HAUS5 Reactome DB_ID: 10549188 1 UniProt:F1NFQ4 HAUS2 UniProt F1NFQ4 1 EQUAL 235 EQUAL Reactome DB_ID: 10549184 1 UniProt:A0A3Q2U1J7 HAUS1 UniProt A0A3Q2U1J7 1 EQUAL 278 EQUAL Reactome DB_ID: 10549204 1 Ghost homologue of HAUS7 [cytosol] Ghost homologue of HAUS7 Reactome DB_ID: 10549192 1 UniProt:A0A3Q2U4A5 HAUS3 UniProt A0A3Q2U4A5 2 EQUAL 603 EQUAL Reactome DB_ID: 10549196 1 UniProt:A0A3Q3AAL7 LOC112531360 UniProt A0A3Q3AAL7 1 EQUAL 363 EQUAL Reactome DB_ID: 10549208 1 UniProt:E1BQW3 UniProt E1BQW3 2 EQUAL 410 EQUAL Reactome DB_ID: 10549202 1 UniProt:F1NQ15 HAUS6 UniProt F1NQ15 1 EQUAL 955 EQUAL Reactome Database ID Release 81 10549210 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549210 Reactome R-GGA-8855211 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8855211.1 Reactome DB_ID: 10549096 1 UniProt:E1BSP2 ODF2 UniProt E1BSP2 1 EQUAL 829 EQUAL Reactome DB_ID: 10549166 1 UniProt:P0CB05 CEP63 UniProt P0CB05 1 EQUAL 703 EQUAL Reactome DB_ID: 10549110 1 UniProt:A0A1D5PCQ7 DCTN2 UniProt A0A1D5PCQ7 2 EQUAL 401 EQUAL Reactome DB_ID: 10549144 1 UniProt:E1C530 CEP78 UniProt E1C530 1 EQUAL 689 EQUAL Reactome DB_ID: 10549152 1 UniProt:F1NQI6 SDCCAG8 UniProt F1NQI6 1 EQUAL 713 EQUAL Reactome DB_ID: 10549052 1 Ghost homologue of PRKACA [cytosol] Ghost homologue of PRKACA Reactome DB_ID: 10549106 1 UniProt:Q5ZM58 ACTR1A UniProt Q5ZM58 1 EQUAL 376 EQUAL Reactome DB_ID: 10549120 1 Ghost homologue of CEP290 [cytosol] Ghost homologue of CEP290 Reactome DB_ID: 10534294 1 UniProt:Q9PTR5 PAFAH1B1 UniProt Q9PTR5 1 EQUAL 410 EQUAL Reactome DB_ID: 10549132 1 Ghost homologue of OFD1 [cytosol] Ghost homologue of OFD1 Reactome DB_ID: 10549162 1 UniProt:F1NYM7 CEP57 UniProt F1NYM7 1 EQUAL 500 EQUAL Reactome DB_ID: 10534376 1 UniProt:F1NCX7 PLK1 UniProt F1NCX7 1 EQUAL 603 EQUAL Reactome DB_ID: 10549064 1 UniProt:A0A3Q3ASK7 SFI1 UniProt A0A3Q3ASK7 1 EQUAL 1242 EQUAL Reactome DB_ID: 10549042 1 Ghost homologue of TUBB4A [cytosol] Ghost homologue of TUBB4A Reactome DB_ID: 10534390 1 UniProt:A0A3Q2U985 CKAP5 UniProt A0A3Q2U985 1 EQUAL 2032 EQUAL Reactome DB_ID: 10549040 1 Ghost homologue of PPP2R1A [cytosol] Ghost homologue of PPP2R1A Reactome DB_ID: 10549140 1 UniProt:E1C7U7 CEP135 UniProt E1C7U7 1 EQUAL 1140 EQUAL Reactome DB_ID: 10549090 1 UniProt:A0A3Q2UPN5 DCTN1 UniProt A0A3Q2UPN5 1 EQUAL 1278 EQUAL Reactome DB_ID: 10549078 1 UniProt:Q8AV28 PCM1 UniProt Q8AV28 1 EQUAL 2024 EQUAL Reactome DB_ID: 10549086 1 UniProt:E1C0R8 CENPJ UniProt E1C0R8 1 EQUAL 1338 EQUAL Reactome Database ID Release 81 10549212 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549212 Reactome R-GGA-380268 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-380268.1 Reactome DB_ID: 113592 1 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP ChEBI 30616 Reactome DB_ID: 10549216 1 centrosome containing phosphorylated Nlp [cytosol] centrosome containing phosphorylated Nlp Reactome DB_ID: 10549126 1 Reactome DB_ID: 10549124 1 1 EQUAL 1460 EQUAL Reactome DB_ID: 10537454 1 1 EQUAL 297 EQUAL Reactome DB_ID: 10549154 1 Reactome DB_ID: 10549060 1 1 EQUAL 3336 EQUAL Reactome DB_ID: 10549056 1 1 EQUAL 172 EQUAL Reactome DB_ID: 10549136 1 1 EQUAL 1012 EQUAL Reactome DB_ID: 10549214 1 Ghost homologue of p-NINL [cytosol] Ghost homologue of p-NINL Reactome DB_ID: 10534278 1 2 EQUAL 268 EQUAL Reactome DB_ID: 10534554 1 1 EQUAL 4646 EQUAL Reactome DB_ID: 10549038 1 1 EQUAL 451 EQUAL Reactome DB_ID: 10534302 1 1 EQUAL 346 EQUAL Reactome DB_ID: 10539916 1 1 EQUAL 451 EQUAL Reactome DB_ID: 10549170 1 1 EQUAL 399 EQUAL Reactome DB_ID: 10549034 1 1 EQUAL 660 EQUAL Reactome DB_ID: 10549148 1 1 EQUAL 659 EQUAL Reactome DB_ID: 10549178 1 1 EQUAL 119 EQUAL Reactome DB_ID: 10549114 1 1 EQUAL 4167 EQUAL Reactome DB_ID: 10530796 1 1 EQUAL 255 EQUAL Reactome DB_ID: 10549102 1 1 EQUAL 186 EQUAL Reactome DB_ID: 10549118 1 1 EQUAL 1941 EQUAL Reactome DB_ID: 10549068 1 1 EQUAL 3911 EQUAL Reactome DB_ID: 10549174 1 1 EQUAL 373 EQUAL Reactome DB_ID: 10539932 1 1 EQUAL 448 EQUAL Reactome DB_ID: 10549098 1 Reactome DB_ID: 10549158 1 1 EQUAL 597 EQUAL Reactome DB_ID: 10534270 1 1 EQUAL 1538 EQUAL Reactome DB_ID: 10534564 1 1 EQUAL 638 EQUAL Reactome DB_ID: 10549070 1 Reactome DB_ID: 10549082 1 1 EQUAL 2442 EQUAL Reactome DB_ID: 10549130 1 1 EQUAL 1083 EQUAL Reactome DB_ID: 10539952 1 1 EQUAL 445 EQUAL Reactome DB_ID: 10532730 1 2 EQUAL 418 EQUAL Reactome DB_ID: 10530766 1 1 EQUAL 247 EQUAL Reactome DB_ID: 10549092 1 Reactome DB_ID: 10549050 1 1 EQUAL 416 EQUAL Reactome DB_ID: 10534568 1 1 EQUAL 89 EQUAL Reactome DB_ID: 10538963 1 1 EQUAL 445 EQUAL Reactome DB_ID: 10549046 1 1 EQUAL 415 EQUAL Reactome DB_ID: 10549074 1 1 EQUAL 2325 EQUAL Reactome DB_ID: 10543056 1 2 EQUAL 732 EQUAL Reactome DB_ID: 10549210 1 Reactome DB_ID: 10549096 1 1 EQUAL 829 EQUAL Reactome DB_ID: 10549166 1 1 EQUAL 703 EQUAL Reactome DB_ID: 10549110 1 2 EQUAL 401 EQUAL Reactome DB_ID: 10549144 1 1 EQUAL 689 EQUAL Reactome DB_ID: 10549152 1 1 EQUAL 713 EQUAL Reactome DB_ID: 10549052 1 Reactome DB_ID: 10549106 1 1 EQUAL 376 EQUAL Reactome DB_ID: 10549120 1 Reactome DB_ID: 10534294 1 1 EQUAL 410 EQUAL Reactome DB_ID: 10549132 1 Reactome DB_ID: 10549162 1 1 EQUAL 500 EQUAL Reactome DB_ID: 10534376 1 1 EQUAL 603 EQUAL Reactome DB_ID: 10549064 1 1 EQUAL 1242 EQUAL Reactome DB_ID: 10549042 1 Reactome DB_ID: 10534390 1 1 EQUAL 2032 EQUAL Reactome DB_ID: 10549040 1 Reactome DB_ID: 10549140 1 1 EQUAL 1140 EQUAL Reactome DB_ID: 10549090 1 1 EQUAL 1278 EQUAL Reactome DB_ID: 10549078 1 1 EQUAL 2024 EQUAL Reactome DB_ID: 10549086 1 1 EQUAL 1338 EQUAL Reactome Database ID Release 81 10549216 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549216 Reactome R-GGA-380704 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-380704.1 Reactome DB_ID: 29370 1 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10534654 O-phospho-L-threonine at 210 (in Homo sapiens) 210 EQUAL O-phospho-L-threonine [MOD:00047] 1 EQUAL 603 EQUAL GO 0004674 GO molecular function Reactome Database ID Release 81 10534655 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10534655 Reactome Database ID Release 81 10549218 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549218 Reactome R-GGA-380272 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-380272.1 Phosphorylation of NlP by Plk1 regulates the interaction of Nlp with both centrosomes and ?-TuRCs (Casenghi et al., 2003). 12852856 Pubmed 2003 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation Casenghi, M Meraldi, P Weinhart, U Duncan, PI K├Ârner, R Nigg, EA Dev Cell 5:113-25 inferred by electronic annotation IEA GO IEA Reactome Database ID Release 81 10616475 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10616475 Reactome R-GGA-380259 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-380259.1 During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity. inferred by electronic annotation IEA GO IEA