BioPAX pathway converted from "ESPL1 (Separase) cleaves centromeric cohesin" in the Reactome database. 3.4 ESPL1 (Separase) cleaves centromeric cohesin ESPL1 (Separase) cleaves centromeric cohesin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10612298 1 chromosome, centromeric region GO 0000775 p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 10612275 1 Ghost homologue of p-S21,S75,T159-CDCA5 [chromosome, centromeric region] Ghost homologue of p-S21,S75,T159-CDCA5 Reactome http://www.reactome.org Converted from EntitySet in Reactome Reactome DB_ID: 10612273 1 PDS5 [chromosome, centromeric region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity PDS5A [chromosome, centromeric region] PDS5B [chromosome, centromeric region] Gallus gallus NCBI Taxonomy 9031 UniProt F1NIQ3 UniProt Q5F3U9 Reactome DB_ID: 1638792 2 chromosome GO 0005694 Sister Centromere [chromosome] Sister Centromere Reactome DB_ID: 10612296 1 p-RAD21-Ac-Cohesin [chromosome, centromeric region] p-RAD21-Ac-Cohesin Reactome DB_ID: 10612287 1 UniProt:A0A1D5PM87 RAD21 UniProt A0A1D5PM87 O-phospho-L-serine at 454 (in Homo sapiens) 454 EQUAL O-phospho-L-serine [MOD:00046] Chain Coordinates 1 EQUAL 631 EQUAL Reactome DB_ID: 10612256 1 Ghost homologue of SMC1A [chromosome, centromeric region] Ghost homologue of SMC1A Reactome DB_ID: 10612250 1 UniProt:A0A1D5NY78 STAG1 UniProt A0A1D5NY78 1 EQUAL 1258 EQUAL Reactome DB_ID: 10612254 1 UniProt:E1BSU3 STAG2 UniProt E1BSU3 1 EQUAL 1231 EQUAL Reactome DB_ID: 10612261 1 UniProt:Q8AWB8 SMC3 SMC3 SMC3 <submittedName> <fullName>Cohesin complex subunit</fullName> </submittedName> UniProt Q8AWB8 N6-acetyl-L-lysine at 105 (in Homo sapiens) 105 EQUAL N6-acetyl-L-lysine [MOD:00064] N6-acetyl-L-lysine at 106 (in Homo sapiens) 106 EQUAL 1 EQUAL 1217 EQUAL Reactome Database ID Release 82 10612296 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10612296 Reactome R-GGA-2500251 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2500251.1 Reactome DB_ID: 10612279 1 UniProt:A0A1D5PYQ6 WAPL UniProt A0A1D5PYQ6 1 EQUAL 1190 EQUAL Reactome DB_ID: 10591284 2 cytosol GO 0005829 Microtubule-bound kinetochore [cytosol] Microtubule-bound kinetochore Reactome DB_ID: 10578585 1 Kinetochore [cytosol] Kinetochore Reactome DB_ID: 10574931 1 UniProt:A0A3Q2TS12 LOC776067 UniProt A0A3Q2TS12 1 EQUAL 3224 EQUAL Reactome DB_ID: 10578257 1 Ghost homologue of CENPA [cytosol] Ghost homologue of CENPA Reactome DB_ID: 10578277 1 UniProt:A0A1I7Q3Z7 MAPRE1 UniProt A0A1I7Q3Z7 2 EQUAL 268 EQUAL Reactome DB_ID: 10578265 1 UniProt:E1C703 CENPF UniProt E1C703 1 EQUAL 3207 EQUAL Reactome DB_ID: 10578375 1 UniProt:F1NCX7 UniProt F1NCX7 1 EQUAL 603 EQUAL Reactome DB_ID: 10578381 1 UniProt:A0A1D5PBU5 UniProt A0A1D5PBU5 1 EQUAL 673 EQUAL Reactome DB_ID: 10578389 1 UniProt:A0A3Q2U985 CKAP5 UniProt A0A3Q2U985 1 EQUAL 2032 EQUAL Reactome DB_ID: 10578293 1 UniProt:Q9PTR5 PAFAH1B1 UniProt Q9PTR5 1 EQUAL 410 EQUAL Reactome DB_ID: 10578261 1 UniProt:E1BQJ6 UniProt E1BQJ6 1 EQUAL 2698 EQUAL Reactome DB_ID: 10578543 1 UniProt:F1NDM5 UniProt F1NDM5 1 EQUAL 1085 EQUAL Reactome DB_ID: 10578539 1 RZZ complex [cytosol] RZZ complex Reactome DB_ID: 10578529 1 Ghost homologue of KNTC1 [cytosol] Ghost homologue of KNTC1 Reactome DB_ID: 10578533 1 UniProt:E1C3T8 ZWILCH UniProt E1C3T8 1 EQUAL 591 EQUAL Reactome DB_ID: 10578537 1 UniProt:A0A1D5PLU6 ZW10 UniProt A0A1D5PLU6 2 EQUAL 779 EQUAL Reactome Database ID Release 82 10578539 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578539 Reactome R-GGA-377885 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377885.1 Reactome DB_ID: 10578385 1 UniProt:E1BW90 SPDL1 UniProt E1BW90 1 EQUAL 605 EQUAL Reactome DB_ID: 10578525 1 UniProt:Q5ZI36 CDC20 UniProt Q5ZI36 1 EQUAL 499 EQUAL Reactome DB_ID: 10578313 1 UniProt:E1C2W6 SGO1 UniProt E1C2W6 1 EQUAL 561 EQUAL Reactome DB_ID: 10578497 1 KMN network [cytosol] KMN network Reactome DB_ID: 10578495 1 NDC80 complex [cytosol] NDC80 complex Reactome DB_ID: 10578483 1 UniProt:Q76I89 NDC80 UniProt Q76I89 1 EQUAL 642 EQUAL Reactome DB_ID: 10578493 1 UniProt:E1C4Y2 SPC25 UniProt E1C4Y2 1 EQUAL 224 EQUAL Reactome DB_ID: 10578489 1 Ghost homologue of SPC24 [cytosol] Ghost homologue of SPC24 Reactome DB_ID: 10578487 1 UniProt:A0A140T8H9 NUF2 UniProt A0A140T8H9 1 EQUAL 464 EQUAL Reactome Database ID Release 82 10578495 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578495 Reactome R-GGA-375444 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375444.1 Reactome DB_ID: 10578463 1 Ghost homologue of CASC5 [cytosol] Ghost homologue of CASC5 Reactome DB_ID: 10578479 1 Mis12 complex [cytosol] Mis12 complex Reactome DB_ID: 10578469 1 Ghost homologue of MIS12 [cytosol] Ghost homologue of MIS12 Reactome DB_ID: 10578477 1 UniProt:A0A3Q3AB20 NNF1 UniProt A0A3Q3AB20 2 EQUAL 205 EQUAL Reactome DB_ID: 10578467 1 UniProt:Q1T768 Dsn1/Q9H410 UniProt Q1T768 1 EQUAL 356 EQUAL Reactome DB_ID: 10578473 1 UniProt:Q1T766 Nsl1/DC31 UniProt Q1T766 1 EQUAL 281 EQUAL Reactome Database ID Release 82 10578479 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578479 Reactome R-GGA-375441 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375441.1 Reactome Database ID Release 82 10578497 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578497 Reactome R-GGA-377745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377745.1 Reactome DB_ID: 10578297 1 UniProt:F1NB03 UniProt F1NB03 1 EQUAL 725 EQUAL Reactome DB_ID: 10578371 1 UniProt:A0A1D5P8H7 XPO1 UniProt A0A1D5P8H7 1 EQUAL 1071 EQUAL Reactome DB_ID: 10578379 1 UniProt:A0A1L1RMC6 PPP1CC UniProt A0A1L1RMC6 2 EQUAL 323 EQUAL Reactome DB_ID: 10578269 1 UniProt:A0A1D5P7I0 CLASP1 UniProt A0A1D5P7I0 1 EQUAL 1538 EQUAL Reactome DB_ID: 10578309 1 UniProt:F1NIE8 RANGAP1 UniProt F1NIE8 2 EQUAL 587 EQUAL Reactome DB_ID: 10578255 1 UniProt:F1NSZ1 INCENP UniProt F1NSZ1 1 EQUAL 918 EQUAL Reactome DB_ID: 10578281 1 UniProt:A0A3Q2U0K2 AHCTF1 UniProt A0A3Q2U0K2 1 EQUAL 2266 EQUAL Reactome DB_ID: 10578333 1 UniProt:A0A1D5NZM5 RCC2 UniProt A0A1D5NZM5 1 EQUAL 522 EQUAL Reactome DB_ID: 10578367 1 PP2A [cytosol] PP2A Converted from EntitySet in Reactome Reactome DB_ID: 10578365 1 PP2A-catalytic subunit C [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Converted from EntitySet in Reactome Reactome DB_ID: 10578353 1 PP2A regulatory subunit B56 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 10578355 1 Ghost homologue of PP2A-subunit A [cytosol] Ghost homologue of PP2A-subunit A Reactome Database ID Release 82 10578367 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578367 Reactome R-GGA-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-196206.1 Reactome DB_ID: 10578273 1 UniProt:A0A3Q2U2T5 CLASP2 UniProt A0A3Q2U2T5 1 EQUAL 1294 EQUAL Reactome DB_ID: 10578547 1 UniProt:F1NCD0 ERCC6L UniProt F1NCD0 1 EQUAL 1250 EQUAL Reactome DB_ID: 10578289 1 1 EQUAL 706 EQUAL Reactome DB_ID: 10578305 1 UniProt:Q5ZKH4 NDEL1 UniProt Q5ZKH4 1 EQUAL 345 EQUAL Reactome DB_ID: 10578461 1 CCAN network [cytosol] CCAN network Reactome DB_ID: 10578403 1 UniProt:F1NSD9 CENPC UniProt F1NSD9 1 EQUAL 943 EQUAL Reactome DB_ID: 10578423 1 UniProt:F1NPG5 CENPT UniProt F1NPG5 1 EQUAL 561 EQUAL Reactome DB_ID: 10578445 1 CENP-O complex [cytosol] CENP-O complex Reactome DB_ID: 10578427 1 UniProt:F1N8S4 CENPO UniProt F1N8S4 1 EQUAL 300 EQUAL Reactome DB_ID: 10578443 1 UniProt:R4GHE0 ITGB3BP UniProt R4GHE0 1 EQUAL 177 EQUAL Reactome DB_ID: 10578439 1 UniProt:F1NUU9 CENPU UniProt F1NUU9 1 EQUAL 418 EQUAL Reactome DB_ID: 10578431 1 UniProt:F1NF34 CENPP UniProt F1NF34 1 EQUAL 288 EQUAL Reactome DB_ID: 10578435 1 UniProt:F1N9M3 CENPQ UniProt F1N9M3 1 EQUAL 268 EQUAL Reactome Database ID Release 82 10578445 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578445 Reactome R-GGA-377886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377886.1 Reactome DB_ID: 10578419 1 UniProt:E1BSW7 CENPS UniProt E1BSW7 1 EQUAL 138 EQUAL Reactome DB_ID: 10578407 1 UniProt:Q1T7C0 CENPL UniProt Q1T7C0 1 EQUAL 344 EQUAL Reactome DB_ID: 10578459 1 CENP-(H,I, K) complex [cytosol] CENP-(H,I, K) complex Reactome DB_ID: 10578449 1 UniProt:Q90ZF9 CENPH UniProt Q90ZF9 1 EQUAL 247 EQUAL Reactome DB_ID: 10578453 1 UniProt:Q8AYS7 CENPI UniProt Q8AYS7 1 EQUAL 756 EQUAL Reactome DB_ID: 10578457 1 UniProt:F1NAR9 CENPK UniProt F1NAR9 1 EQUAL 269 EQUAL Reactome Database ID Release 82 10578459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578459 Reactome R-GGA-377884 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377884.1 Reactome DB_ID: 10578411 1 UniProt:Q1T7B9 CENPM UniProt Q1T7B9 1 EQUAL 180 EQUAL Reactome DB_ID: 10578415 1 UniProt:Q1T765 CENPN UniProt Q1T765 1 EQUAL 339 EQUAL Reactome Database ID Release 82 10578461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578461 Reactome R-GGA-377738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377738.1 Reactome DB_ID: 10578329 1 UniProt:E1BWA7 SKA2P1 UniProt E1BWA7 1 EQUAL 121 EQUAL Reactome DB_ID: 10578583 1 Dynein complex [cytosol] Dynein complex Reactome DB_ID: 10578555 1 DHC dimer [cytosol] DHC dimer Reactome DB_ID: 10578553 2 UniProt:F1NKL4 DYNC1H1 UniProt F1NKL4 1 EQUAL 4646 EQUAL Reactome Database ID Release 82 10578555 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578555 Reactome R-GGA-2029144 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2029144.1 Converted from EntitySet in Reactome Reactome DB_ID: 10578565 2 DICs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity DYNC1I1 [cytosol] DYNC1I2 [cytosol] UniProt E1C7N2 UniProt F1P3C8 Converted from EntitySet in Reactome Reactome DB_ID: 10578581 2 DLIs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity DYNC1LI2 [cytosol] DYNC1LI1 [cytosol] UniProt A0A3Q2U6P7 UniProt Q90828 Converted from EntitySet in Reactome Reactome DB_ID: 10578571 2 DLCs [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity DYNLL1 [cytosol] DYNLL2 [cytosol] UniProt F1N8L5 UniProt F1NRI4 Reactome Database ID Release 82 10578583 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578583 Reactome R-GGA-2029145 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2029145.1 Reactome DB_ID: 10578335 1 Ghost homologue of ZWINT [cytosol] Ghost homologue of ZWINT Reactome DB_ID: 10578251 1 UniProt:E1BRU0 MAD1L1 UniProt E1BRU0 1 EQUAL 718 EQUAL Reactome DB_ID: 10578395 1 UniProt:O42184 CLIP1 UniProt O42184 1 EQUAL 1438 EQUAL Reactome DB_ID: 10578549 1 Ghost homologue of TAOK1 [cytosol] Ghost homologue of TAOK1 Reactome DB_ID: 10578399 1 UniProt:F1NE97 NUDC UniProt F1NE97 1 EQUAL 331 EQUAL Reactome DB_ID: 10578509 1 Chromosome passenger complex [cytosol] Chromosome passenger complex Reactome DB_ID: 10578499 1 Ghost homologue of AURKB [cytosol] Ghost homologue of AURKB Reactome DB_ID: 10578503 1 UniProt:F1NN48 BIRC5 UniProt F1NN48 1 EQUAL 142 EQUAL Reactome DB_ID: 10578255 1 1 EQUAL 918 EQUAL Reactome DB_ID: 10578507 1 UniProt:A0A1D5PYM7 LOC107057175 UniProt A0A1D5PYM7 1 EQUAL 280 EQUAL Reactome Database ID Release 82 10578509 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578509 Reactome R-GGA-377879 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377879.1 Reactome DB_ID: 10578301 1 UniProt:Q5ZMC9 NDE1 UniProt Q5ZMC9 1 EQUAL 346 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10578323 1 Homologues of SGOL2 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity SGOL2 [cytosol] SGO2 [cytosol] UniProt A0A3Q2U0Z0 UniProt A0A3Q2TXN6 Reactome DB_ID: 10578527 1 Mitotic checkpoint complex [cytosol] Mitotic checkpoint complex Reactome DB_ID: 10578517 1 UniProt:A0A1D5PR30 BUB1B UniProt A0A1D5PR30 1 EQUAL 1050 EQUAL Reactome DB_ID: 10578521 1 UniProt:A0A1L1RRQ2 BUB3 UniProt A0A1L1RRQ2 1 EQUAL 328 EQUAL Reactome DB_ID: 10578525 1 1 EQUAL 499 EQUAL Reactome DB_ID: 10578513 1 UniProt:A0A1L1RLV7 MAD2L1 UniProt A0A1L1RLV7 2 EQUAL 205 EQUAL Reactome Database ID Release 82 10578527 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578527 Reactome R-GGA-377882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377882.1 Reactome DB_ID: 10578285 1 UniProt:E1BUZ2 UniProt E1BUZ2 1 EQUAL 898 EQUAL Reactome DB_ID: 10574999 1 Nup107-160 complex [cytosol] Nup107-160 complex Reactome DB_ID: 10574991 1 UniProt:E1C370 UniProt E1C370 1 EQUAL 380 EQUAL Reactome DB_ID: 10574975 1 UniProt:F1NDV3 NUP133 UniProt F1NDV3 1 EQUAL 1156 EQUAL Reactome DB_ID: 10574995 1 UniProt:A0A1L1RNL7 SEC13 UniProt A0A1L1RNL7 2 EQUAL 322 EQUAL Reactome DB_ID: 10574971 1 UniProt:A0A3Q2UD87 NUP107 UniProt A0A3Q2UD87 1 EQUAL 925 EQUAL Reactome DB_ID: 10574983 1 UniProt:A0A1D5PBD8 NUP98 UniProt A0A1D5PBD8 1 EQUAL 880 EQUAL Reactome DB_ID: 10574997 1 UniProt:A0A1D5NZU0 SEH1L UniProt A0A1D5NZU0 1 EQUAL 360 EQUAL Reactome DB_ID: 10574987 1 UniProt:E1BYD2 NUP37 UniProt E1BYD2 1 EQUAL 326 EQUAL Reactome DB_ID: 10574981 1 UniProt:F1NRW5 NUP85 UniProt F1NRW5 1 EQUAL 656 EQUAL Reactome DB_ID: 10574977 1 Ghost homologue of NUP160 [cytosol] Ghost homologue of NUP160 Reactome Database ID Release 82 10574999 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10574999 Reactome R-GGA-377883 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-377883.1 Reactome DB_ID: 10573214 1 UniProt:A0A1D5NZ06 RPS27 UniProt A0A1D5NZ06 2 EQUAL 84 EQUAL Reactome DB_ID: 10578325 1 Ghost homologue of SKA1 [cytosol] Ghost homologue of SKA1 Reactome DB_ID: 10578391 1 Ghost homologue of B9D2 [cytosol] Ghost homologue of B9D2 Reactome Database ID Release 82 10578585 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10578585 Reactome R-GGA-375305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375305.1 Reactome DB_ID: 10583985 15 Microtubule [cytosol] Microtubule Reactome DB_ID: 10583983 13 Microtubule protofilament [cytosol] Microtubule protofilament Reactome Database ID Release 82 10583985 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10583985 Reactome R-GGA-190599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-190599.1 Reactome Database ID Release 82 10591284 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10591284 Reactome R-GGA-375303 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-375303.1 Reactome Database ID Release 82 10612298 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10612298 Reactome R-GGA-2500242 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2500242.1 Reactome DB_ID: 10620437 1 Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Reactome DB_ID: 10612275 1 Reactome DB_ID: 10578585 2 Reactome DB_ID: 10583985 30 Converted from EntitySet in Reactome Reactome DB_ID: 10612273 1 Reactome DB_ID: 1638792 2 Reactome DB_ID: 10620435 1 Cleaved Cohesin [chromosome, centromeric region] Cleaved Cohesin Reactome DB_ID: 10612250 1 1 EQUAL 1258 EQUAL Reactome DB_ID: 10612256 1 Reactome DB_ID: 10612254 1 1 EQUAL 1231 EQUAL Reactome DB_ID: 10620433 1 173 EQUAL 450 EQUAL Reactome DB_ID: 10620431 1 1 EQUAL 172 EQUAL Reactome DB_ID: 10612261 1 N6-acetyl-L-lysine at 105 (in Homo sapiens) 105 EQUAL N6-acetyl-L-lysine at 106 (in Homo sapiens) 106 EQUAL 1 EQUAL 1217 EQUAL Reactome DB_ID: 10620429 1 O-phospho-L-serine at 454 (in Homo sapiens) 454 EQUAL 451 EQUAL 631 EQUAL Reactome Database ID Release 82 10620435 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10620435 Reactome R-GGA-2467801 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2467801.1 Reactome DB_ID: 10612279 1 1 EQUAL 1190 EQUAL Reactome Database ID Release 82 10620437 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10620437 Reactome R-GGA-2467806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2467806.1 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10620398 ESPL1 Autocleaved [cytosol] ESPL1 Autocleaved Reactome DB_ID: 10620396 1 UniProt:A0A1D5PK16 ESPL1 UniProt A0A1D5PK16 1507 EQUAL 1535 EQUAL Reactome DB_ID: 10620394 1 1 EQUAL 1506 EQUAL Reactome DB_ID: 10620392 1 1536 EQUAL 2120 EQUAL Reactome Database ID Release 82 10620398 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10620398 Reactome R-GGA-2467770 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2467770.1 GO 0008234 GO molecular function Reactome Database ID Release 82 10620438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10620438 Reactome Database ID Release 82 10620440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10620440 Reactome R-GGA-2467809 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2467809.1 ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit of centromeric cohesin at two sites that conform to the consensus separase recognition site E-X-X-R: after arginine residue R172 and after arginine residue R450 (Hauf et al. 2001). Phosphorylation of RAD21 at the serine residue S454 by PLK1 in prometaphase facilitates ESPL1-mediated cleavage of RAD21 at the C-terminal cleavage site R450 (Hauf et al. 2005). The N-terminal and C-terminal RAD21 cleavage fragments remain bound to the rest of the cohesin complex (Deardorff et al. 2012). It is not clear whether RAD21 middle fragment also continues to be associated with cohesin. 22885700 Pubmed 2012 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle Deardorff, Matthew A Bando, Masashige Nakato, Ryuichiro Watrin, Erwan Itoh, Takehiko Minamino, Masashi Saitoh, Katsuya Komata, Makiko Katou, Yuki Clark, Dinah Cole, Kathryn E De Baere, Elfride Decroos, Christophe Di Donato, Nataliya Ernst, Sarah Francey, Lauren J Gyftodimou, Yolanda Hirashima, Kyotaro Hullings, Melanie Ishikawa, Yuuichi Jaulin, Christian Kaur, Maninder Kiyono, T Lombardi, Patrick M Magnaghi-Jaulin, L Mortier, Geert R Nozaki, Naohito Petersen, Michael B Seimiya, Hiroyuki Siu, Victoria M Suzuki, Yutaka Takagaki, Kentaro Wilde, Jonathan J Willems, Patrick J Prigent, Claude Gillessen-Kaesbach, Gabriele Christianson, DW Kaiser, Frank J Jackson, Laird G Hirota, Toru Krantz, Ian D Shirahige, Katsuhiko Nature 489:313-7 11509732 Pubmed 2001 Cohesin cleavage by separase required for anaphase and cytokinesis in human cells Hauf, S Waizenegger, IC Peters, JM Science 293:1320-3 15737063 Pubmed 2005 Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 Hauf, S Roitinger, E Koch, B Dittrich, CM Mechtler, K Peters, JM PLoS Biol 3:e69 inferred by electronic annotation IEA GO IEA